数字农科院2.0

Single-worm quantitative proteomics reveals aging heterogeneity in isogenic Caenorhabditis elegans

文献类型： 外文期刊

作者： Zhu, Tian-Yi;Li, Shang-Tong;Liu, Dan-Dan;Zhang, Xiajun;Zhou, Lianqi;Zhou, Rong;Yang, Bing

作者机构：

关键词： aging;mass spectrometry;single worm proteomics

期刊名称： AGING CELL

ISSN： 1474-9718

年卷期： 2023 年

页码：

收录情况： SCIE（2023版）

摘要： The heterogeneity of aging has been investigated at cellular and organic levels in the mouse model and human, but the exploration of aging heterogeneity at whole-organism level is lacking. C. elegans is an ideal model organism for studying this question as they are self-fertilized and cultured in the same chamber. Despite the tremendous progress made in single-cell proteomic analysis, there is few single-worm proteomics studies about aging. Here, we apply single-worm quantitative mass spectrometry to quantify the heterogenous proteomic changes during aging across individuals, a total of 3524 proteins from 157 C. eleagns individuals were quantified. A reconstructed C. elegans aging trajectory and proteomic landscape of fast-aging individuals were used to analyze the heterogeneity of C. elegans aging. We characterized inter-individual proteomic variation during aging and revealed contributing factors that distinguish fast-aging individuals from their siblings.

分类号：

  • 相关文献

[1]Impact of chiral tebuconazole on the flavor components and color attributes of Merlot and Cabernet Sauvignon wines at the enantiomeric level. Zhao S., Li M., Simal-Gandara J.,田健., Chen J., Dai X., Kong Z.. 2022

[2]Aging of nickel added to soils as predicted by soil pH and time. Ma, Yibing,Ma, Yibing,Lombi, Enzo,McLaughlin, Mike J.,Oliver, Ian W.,Nolan, Annette L.,Lombi, Enzo,McLaughlin, Mike J.,Oorts, Koen,Smolders, Erike.

[3]Aging effects on molybdate lability in soils. Kirby, Jason K.,McLaughlin, Michael J.,Ma, Yibing,Ma, Yibing,Ajiboye, Babasola.

[4]SHORT-TERM NATURAL ATTENUATION OF COPPER IN SOILS: EFFECTS OF TIME, TEMPERATURE, AND SOIL CHARACTERISTICS. Ma, YB,Lombi, E,Nolan, AL,McLaughlin, MJ.

[5]Aging of zinc added to soils with a wide range of different properties: Factors and modeling. Zhang, Xi,Jiang, Bao,Ma, Yibing.

[6]Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats. Gao, Hui,Yan, Peipei,Huang, Hao,Sun, Taoping,Chen, Sijing,Liu, Liegang,Gao, Hui,Yan, Peipei,Zhang, Shun,Huang, Hao,Sun, Taoping,Chen, Sijing,Liu, Liegang,Huang, Fenghong,Deng, Qianchun,Huang, Qingde,Xu, Jiqu,Huang, Fenghong,Deng, Qianchun,Huang, Qingde,Xu, Jiqu,Ye, Keqiang.

[7]Effect of aging on the availability of zinc added to a calcareous clay soil. Ma, Y. B.,Uren, N. C..

[8]Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2 alpha signaling pathway. Gao, Hui,Yan, Peipei,Han, Hao,Yang, Wei,Yao, Ping,Liu, Liegang,Gao, Hui,Yan, Peipei,Zhang, Shun,Han, Hao,Yang, Wei,Yao, Ping,Liu, Liegang,Nie, Shuke,Huang, Fenghong,Deng, Qianchun,Huang, Qingde,Xu, Jiqu,Huang, Fenghong,Deng, Qianchun,Huang, Qingde,Xu, Jiqu,Wu, Hailei,Ye, Keqiang. 2016

[9]Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge. Wen, Zhiyuan,Ye, Ling,Gao, Yulong,Pan, Lei,Dong, Ke,Compans, Richard W.,Yang, Chinglai,Wen, Zhiyuan,Ye, Ling,Gao, Yulong,Pan, Lei,Dong, Ke,Compans, Richard W.,Yang, Chinglai,Wen, Zhiyuan,Gao, Yulong,Bu, Zhigao,Pan, Lei,Dong, Ke. 2009

[10]Change Of The Extractability Of C.admium Added To Different S oils: Aging Effect And Modeling. Zhang, X, Zeng, SQ, Chen, SB, Ma, YB. 2018

[11]Transcriptomic analysis of laying hens revealed the role of aging-related genes during forced molting. Tongyu Zhang,Yu Chen,Junhui Wen,Yaxiong Jia,Liang Wang,Xueze Lv,Weifang Yang,Changqing Qu,Haiying Li,Huie Wang,Lujiang Qu,Zhonghua Ning. 2021

[12]Effect of three aging processes on physicochemical and As(V) adsorption properties of Ce/Mn-modified biochar. Huang X.,Lyu P.,Li L.,Xie J.,Zhu C.. 2022

[13]Effects of the aging of immobilization materials on the stability of immobilization remediation of cd-contaminated paddy soil. Shan Z.-J.,Chen Y.-H.,Zhang L.,Liu Y.,Jiao W.-X.,Lin D.-S.. 2021

[14]Experimental study on durability of wood-plastic composites by coupling dry-wet cycles and seawater environment. Jiang, Liangpeng,Li, Xiaokai,Fu, Jingjing,Teng, Wenxiang,Yang, Hongtao. 2022

[15]Coating seeds with biopolymers extracted from waste-activated sludge. Chen Shi,Shi Chao Yuan,Lin Zhang,Xiang Yang Wang,Li Ting Hao,Shi Ming Su,Zhongfang Lei,Xiao Di Hao. 2024

[16]Has the Household Old-Age Burden Affected Farm Household Incomes? Evidence from a Survey of Chinese Farm Households. Hongwei Lu,Mingjie Gao,Guojing Li,Tingting Li,Qiyou Luo. 2024

[17]Uterine microbial communities and their potential role in the regulation of epithelium cell cycle and apoptosis in aged hens. Dong Dai,Jing Wang,Haijun Zhang,Shugeng Wu,Guanghai Qi. 2023

[18]Causal Analysis Between Gut Microbes, Aging Indicator, and Age-Related Disease, Involving the Discovery and Validation of Biomarkers. Lu, Chunrong,Wang, Xiaojun,Chen, Xiaochun,Qin, Tao,Ye, Pengpeng,Liu, Jianqun,Wang, Shuai,Luo, Weifei. 2025

[19]Nuciferine alleviates cognitive impairment by modulating endoplasmic reticulum stress in D-galactose-induced aging mice. Xiaojie Yang,Juntao Zhang,Weimin Wang,Xinyan Wu,Yuxuan Liu,Jianjun Deng,Haixia Yang. 2025

[20]Metabolic Dynamics and Sensory Impacts of Aging on Peony Mead: Insights into Nonenzymatic Reactions. Yuqian Ban,Yanli Zhang,Yongrui Ti,Ruiwen Lu,Jiaoling Wang,Zihan Song. 2025

作者其他论文 更多>>