数字农科院2.0

Integrated proteomics and metabolomics elucidate HSD17B12 regulation of intramuscular fat deposition for enhanced beef quality

文献类型： 外文期刊

作者： Yuan Liu;Shuang Liu;Xue Feng;Mengli Yang;Xue Bai;Dawei Wei;Bei Cai;Runjun Yang;Lupei Zhang;Yun Ma

作者机构：

关键词： DIA-PRM;Lipid metabolism;Longissimus dorsi;Muscle quality

期刊名称： Food Chemistry: Molecular Sciences

ISSN： 2666-5662

年卷期： 2025 年 11 卷

页码：

收录情况： ESCI（2025版）

摘要： Intramuscular fat (IMF) critically governs beef sensory attributes (juiciness, tenderness, flavor). Previous studies have predominantly focused on genomics and transcriptomics, with limited proteomic data available. To gain a more comprehensive understanding of the mechanisms regulating IMF deposition, we integrated proteomic and metabolomic profiling of the Longissimus dorsi across three genetically distinct cattle breeds. A comprehensive analysis of 633 differentially abundant proteins (DAPs) and 1456 differential metabolites (DAMs) identified 20 potential protein regulators (e.g., ACAA1, ACACA, ADIPOQ, and HSD17B12) and 19 candidate metabolites (e.g., hexadecanoic acid, icosadienoic acid, oleic acid, and oxaloacetate) as key molecular markers. Furthermore, HSD17B12 was found to inhibit IMF cell proliferation while promoting differentiation and lipid accumulation. This integrated approach highlights HSD17B12 as a critical regulator in enhancing IMF content, providing a theoretical foundation for improving beef quality.

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