数字农科院2.0

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

文献类型： 外文期刊

作者： Jumei Zheng;Qi Zhang;Xinxin Tang;Fan Ying;Dawei Liu;Sen Li;Ranran Liu;Jie Wen;Qing He Li;Guiping Zhao

作者机构：

关键词： arachidonic acid metabolism;broiler;fatty acid degradation;leg abnormality;metabolomic

期刊名称： Animal Research and One Health

ISSN： 2835-5075

年卷期： 2025 年 3 卷 4 期

页码：

收录情况： 无来源刊（2025版）

摘要： Rapid body weight gain in broilers overloads the metabolic system of the organism, resulting in leg abnormalities, which seriously affects animal welfare and industry economics. In this study, broilers with normal and deformed leg bones were examined. Serum biochemical indices showed that the serum calcium to phosphorus ratio was extremely decreased in leg deformed group. In addition, abnormal serum lipid levels suggested a disruption in lipid metabolism. Based on widely targeted metabonomic analysis of serum and cartilage tissues, a total of nine differential metabolites (DMs) significantly associated with leg abnormalities and serum calcium and phosphorus levels were screened, including carnitine C16:0, carnitine C18:1, 3-hydroxymethyl-L-tyrosine, cis-4-hydroxy-D-proline, cis-L-3-hydroxyproline, trans-4-hydroxy-L-proline, and so on. Pathway analysis revealed that fatty acid degradation and arachidonic acid metabolism were enriched. Analysis of DMs in these two pathways showed that prostaglandin D2, prostaglandin J2, prostaglandin A2, 15-keto prostaglandin F2α, and Δ12-prostaglandin J2 significantly differed between the normal and abnormal groups. It was hypothesized that these important metabolic pathways and metabolites were involved in the metabolic regulation of leg abnormalities.

分类号：

  • 相关文献

[1]Integrative Analysis of Transcriptome and Metabolome Reveals Molecular Mechanisms Underlying Hepatic Differences Between Zaozhuang Heigai Piglets and Duroc×Landrace×Yorkshire Piglets. Caitong Wang,Jingxuan Li,Xueyan Zhao,Yanping Wang,Xiaodong Zhu,Fuping Zhao,Chuansheng Zhang,Liying Geng,Jiying Wang. 2026

[2]Selenomethionine Regulates the Arachidonic Acid Metabolism-Ferroptosis-Inflammation Axis to Ameliorate Colitis. Tian, Huihui,Zhou, Longzhu,Feng, Xiaohui,Shen, Jialu,Du, Xiaoping,Zhao, Qingyu,Qin, Yuchang,Zhang, Junmin,Tang, Chaohua. 2026

[3]Transcriptomic and metabolomic effects of exogenous ABA application on tobacco seedling growth. Deng, Jiahui,Jiao, Qin,Wang, Yi,Lei, Ting,Ding, ZhongLin,Wang, Jie,Jiang, Xingyin,Zhang, Fengwen. 2023

[4]Transcriptomic and Metabolomic Analysis of the Effects of Exogenous Trehalose on Salt Tolerance in Watermelon (Citrullus lanatus). Yuan, Gaopeng,Sun, Dexi,An, Guolin,Li, Weihua,Si, Wenjing,Liu, Junpu,Zhu, Yingchun. 2022

[5]Hemolymph Metabolism Analysis of Honey Bee (Apis mellifera L.) Response to Different Bee Pollens. Chang H.,Ding G.,Jia G.,Feng M.,Huang J.. 2023

[6]Conjoint analysis of transcriptome and metabolome profiles of normal captivity and arch soil free-range in Meishan pigs. Ying Liu,Yanlong Su,Zhijie Zhou,Jie Zhu,Qianqian Zhu,Peng Xie,Shiquan Qian,Liwei Wang,Tong Qin,Gang Zhou. 2023

[7]Integrated metabolomics and transcriptomics analysis reveals new biomarkers and mechanistic insights on atrazine exposures in MCF‑7 cells. Yu Shun Lu,Shang Lin Yang,Chun Lin Gou,Xin Lu Wang,Xing Wen,Xiao Rong He,Xiao Xuan Guo,Yan Yang Xu,Jiang Yu,Jing Qiu,Yong Zhong Qian. 2022

[8]Dynamic Changes in Non-Volatile Components during Steamed Green Tea Manufacturing Based on Widely Targeted Metabolomic Analysis. Anhui Gui,Shiwei Gao,Pengcheng Zheng,Zhihui Feng,Panpan Liu,Fei Ye,Shengpeng Wang,Jinjin Xue,Jun Xiang,Dejiang Ni,Junfeng Yin. 2023

[9]Active compound analysis of Ziziphus jujuba cv. Jinsixiaozao in different developmental stages using metabolomic and transcriptomic approaches. Bingqi Shen,Zhong Zhang,Qianqian Shi,Jiangtao Du,Qingtun Xue,Xingang Li. 2022

[10]Metabolite and Proteomic Profiling of Serum Reveals the Differences in Molecular Immunity between Min and Large White Pig Breeds. Liyu Yang,Xin Liu,Xiaoyu Huang,Longchao Zhang,Hua Yan,Xinhua Hou,Lixian Wang,Ligang Wang. 2023

[11]Dynamic variation of nutrient absorption, metabolomic and transcriptomic indexes of soybean (Glycine max) seedlings under phosphorus deficiency. Li, Mingxia,Zhou, Ji,Liu, Qi,Mao, Lili,Li, Haoru,Li, Shuying,Guo, Rui. 2023

[12]Integrative omics analyses of tea (Camellia sinensis) under glufosinate stress reveal defense mechanisms: A trade-off with flavor loss. Huan Yu,Dong Li,Yangliu Wu,Peijuan Miao,Chunran Zhou,Haiyan Cheng,Qinyong Dong,Yingjie Zhao,Zhusheng Liu,Li Zhou,Canping Pan. 2024

[13]Multi-omics analyses reveal the responses of wheat (Triticum aestivum L.) and rhizosphere bacterial community to nano(micro)plastics stress. Zhuang M.,Qiao C.,Han L.,Bi Y.,Cao M.,Wang S.,Guo L.,Pang R.,Xie H.. 2024

[14]Transcriptomic and Metabolomic Profiling Provides Insights into Flavonoid Biosynthesis and Flower Coloring in Loropetalum chinense and Loropetalum chinense var. rubrum. Xia Zhang,Li Zhang,Damao Zhang,Yang Liu,Ling Lin,Xingyao Xiong,Donglin Zhang,Ming Sun,Ming Cai,Xiaoying Yu,Yanlin Li. 2023

[15]Comparative Analysis of Transcriptomics and Metabolomics Reveals Defense Mechanisms in Melon Cultivars against Pseudoperonospora cubensis Infection. Ling, Yueming,Xiong, Xianpeng,Yang, Wenli,Liu, Bin,Shen, Yue,Xu, Lirong,Lu, Fuyuan,Li, Meihua,Guo, Yangdong,Zhang, Xuejun. 2024

[16]Multi-omic analysis of the extension of broccoli quality during storage by folic acid. Zhao, Yaqi,Shi, Junyan,Feng, Bihong,Yuan, Shuzhi,Yue, Xiaozhen,Shi, Wenlin,Yan, Zhicheng,Xu, Dongying,Zuo, Jinhua,Wang, Qing. 2024

[17]Proteomic and Metabolomic Profiling Elucidate the Impact of PEDV on Yorkshire Piglets and Reveal the Underlying Molecular Mechanism of PEDV Response. Shi L.,Li H.,Zhou C.,Wang L.. 2024

[18]Metabolome profiling unveil the composition differences of quality of different tea cultivars. Xuecheng Zhao,Ning Chi,Xiaoying Xu,Jun Lai,Jiedan Chen,Liang Chen. 2024

[19]Comprehensive metabolic profiling of dioxin-like compounds exposure in laying hens: Implications for toxicity assessment. Xiaoxu Hu,Tong Xu,Yangsheng Chen,Qian Zhang,Lijuan Tang,Liping Zheng,Chu Wang,Pu Wang,Shujun Dong,Ruiguo Wang,Su Zhang,Qinghua Zhang,Heidi Qunhui Xie,Li Xu,Bin Zhao. 2024

[20]Metabolomic and transcriptomic analyses reveal MYB-Related genes involved in drought resistance in grafted potatoes via the flavonoid pathway. Yinqiao Jian,Chunyan Gao,Yangyang Shang,Junhong Qin,Shaoguang Duan,Chunsong Bian,Guangcun Li. 2024

作者其他论文 更多>>