A chromosome-scale genome provides new insights into the typical carotenoid biosynthesis in the important red yeast Rhodotorula glutinis QYH-2023 with anti-inflammatory effects
文献类型: 外文期刊
作者: Qiaoyun He;Shasha Bai;Chenxiao Chen;Xiai Yang;Zhimin Li;Shitao Sun;Xiaoxin Qu;Xiushi Yang;Jiangpeng Pan;Wei Liu;Chunsheng Hou;Yanchun Deng
作者机构:
关键词: Carotenoid biosynthesis;Genome;Rhodotorula glutinis
期刊名称: International Journal of Biological Macromolecules
ISSN: 0141-8130
年卷期: 2024 年 269 卷
页码:
收录情况: SCIE(2024版) ; ; EI(2024版)
摘要: Rhodotorula spp. has been studied as one powerful source for a novel cell factory with fast growth and its high added-value biomolecules. However, its inadequate genome and genomic annotation have hindered its widespread use in cosmetics and food industries. Rhodotorula glutinis QYH-2023, was isolated from rice rhizosphere soil, and the highest quality of the genome of the strain was obtained at chromosome level (18 chromosomes) than ever before in red yeast in this study. Comparative genomics analysis revealed that there are more key gene copies of carotenoids biosynthesis in R. glutinis QYH-2023 than other species of Rhodotorula spp. Integrated transcriptome and metabolome analysis revealed that lipids and carotenoids biosynthesis was significantly enriched during fermentation. Subsequent investigation revealed that the over-expression of the strain three genes related to carotenoids biosynthesis in Komagataella phaffii significantly promoted the carotenoid production. Furthermore, in vitro tests initially confirmed that the longer the fermentation period, the synthesized metabolites controlled by R. glutinis QYH-2023 genome had the stronger anti-inflammatory properties. All of the findings revealed a high-quality reference genome which highlight the potential of R. glutinis strains to be employed as chassis cells for biosynthesizing carotenoids and other active chemicals.
分类号:
- 相关文献
作者其他论文 更多>>
-
Long-term aging of oxychar and biochar: structural, adsorptive, and microbial transformations
作者:Cheng Ji;Shutao Wang;Man Zhang;Hang Sun;Qinggang Meng;Kexin Zhao;Yifan Li;Shiming Su;Bing Han;Wei Liu
关键词:Biochar aging;Heavy metal adsorption;Microbial succession;Oxychar;Soil organic matter
-
Preparation, Modification, Food Application, and Health Effects of Protein and Peptide from Hemp (Cannabis sativa L.) Seed: A Review of the Recent Literature
作者:Xiaoqin Zhang;Wei Zhou;Xiaoli Qin;Chunsheng Hou;Xiushi Yang
关键词:bioactive peptide;food application;health effects;hemp seed protein;structure modification
-
Data-driven machine learning modeling reveals the impact of micro/nanoplastics on microalgae and their key underlying mechanisms
作者:Houyu Li;Yaxu Pang;Yinuo Ding;Zhengzhe Fan;Yan Xu;Wei Liu
关键词:Activity;Machine Learning;Micro/nanoplastics;Microalgae;Predicted
-
A single-cell transcriptomic atlas reveals the cell differentiation trajectory and the response to virus invasion in swelling clove of garlic
作者:Song Gao;Fu Li;Zheng Zeng;Qiaoyun He;Hassan H.A. Mostafa;Suling Zhang;Taotao Wang;Yanzhou Wang;Touming Liu
关键词:
-
Protein phosphorylation networks in Baylisascaris procyonis revealed by phosphoproteomic analysis
作者:Qin Meng;Zhikang Li;Qiguan Qiu;Shuyu Chen;Haiyan Gong;Xiaoruo Tan;Xiaoheng Liu;Zhaoguo Chen;Wei Liu
关键词:Baylisascaris procyonis;Function;Liquid chromatography-mass spectrometry;Phosphoproteome;Raccoon;Signaling pathway
-
Dietary addition of compound organic acids improves the growth performance, carcass trait, and body health of broilers
作者:Fang Cai;Meiping Huang;Wei Liu;Xiaoling Wan;Kai Qiu;Xiao Xu
关键词:broilers;compound organic acids;dietary supplementation;growth characteristics;lipid metabolism
-
Molecular Mechanism of VSV-Vectored ASFV Vaccine Activating Immune Response in DCs
作者:Yunyun Ma;Junjun Shao;Wei Liu;Shandian Gao;Guangqing Zhou;Xuefeng Qi;Huiyun Chang
关键词:antigen presentation;ASFV;dendritic cells;immune response;recombinant viruses