数字农科院2.0

Large-scale metabolomic landscape of edible maize reveals convergent changes in metabolite differentiation and facilitates its breeding improvement

文献类型： 外文期刊

作者： Chunhui Li;Zhiyong Li;Baishan Lu;Yaxing Shi;Senlin Xiao;Hui Dong;Ruyang Zhang;Hui Liu;Yanyan Jiao;Li Xu;Aiguo Su;Xiaqing Wang;Yanxin Zhao;Shuai Wang;Yanli Fan;Meijie Luo;Shengli Xi;Ainian Yu;Fengge Wang;Jianrong Ge;Hongli Tian;Hongmei Yi;Yuanda Lv;Huihui Li;Ronghuan Wang;Wei Song;Jiuran Zhao

作者机构：

关键词： diversifying selection;metabolite differentiation;metabolome database;sweet maize;waxy maize

期刊名称： Molecular Plant

ISSN： 1674-2052

年卷期： 2025 年 18 卷 4 期

页码：

收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版）

摘要： Edible maize is an important food crop that provides energy and nutrients to meet human health and nutritional requirements. However, how environmental pressures and human activity have shaped the metabolome of edible maize remains unclear. In this study, we collected 452 diverse edible maize accessions worldwide, including waxy, sweet, and field maize. A total of 3020 non-redundant metabolites, including 802 annotated metabolites, were identified using a two-step optimized approach, which generated the most comprehensive annotated metabolite dataset in plants to date. Although specific metabolite differentiation was detected between field and sweet maize and between field and waxy maize, convergent metabolite differentiation was the dominant pattern. We identified hub genes in all metabolite classes by hotspot analysis in a metabolite genome-wide association study. Seventeen and 15 hub genes were selected as the key differentiation genes for flavonoids and lipids, respectively. Surprisingly, almost all of these genes were under diversifying selection, suggesting that diversifying selection was the main genetic mechanism of convergent metabolic differentiation. Further genetic and molecular studies revealed the roles and genetic diversifying selection mechanisms of ZmGPAT11 in convergent metabolite differentiation in the lipid pathway. On the basis of our research, we established the first edible maize metabolome database, EMMDB (https://www.maizemdb.site/home/). We successfully used EMMDB for precision improvement of nutritional and flavor traits and bred the elite inbred line 6644_2, with greatly increased contents of flavonoids, lysophosphatidylcholines, lysophosphatidylethanolamines, and vitamins. Collectively, our study sheds light on the genetic mechanisms of metabolite differentiation in edible maize and provides a database for breeding improvement of flavor and nutritional traits in edible maize by metabolome precision design.

分类号：

  • 相关文献

[1]Trade-offs and evolution of thermal adaptation in the Irish potato famine pathogen Phytophthora infestans. Yang, Li-Na,Zhu, Wen,Wu, E-Jiao,Yang, Ce,Shang, Li-Ping,Thrall, Peter H.,Burdon, Jeremy J.,Jin, Li-Ping,Zhan, Jiasui.

[2]Effects of waterlogging at different stages on growth and ear quality of waxy maize. Chao Huang,Weiqiang Zhang,Hui Wang,Yang Gao,Shoutian Ma,Anzhen Qin,Zugui Liu,Ben Zhao,Dongfeng Ning,Hongjian Zheng,Zhandong Liu. 2022

[3]Physiological Mechanism of Waterlogging Stress on Yield of Waxy Maize at the Jointing Stage. Xuepeng Zhang,Chao Huang,Ye Meng,Xuchen Liu,Yang Gao,Zhandong Liu,Shoutian Ma. 2023

[4]Integrative transcriptome and metabolome analysis reveals the mechanisms of light-induced pigmentation in purple waxy maize. Yuan Lu,Yao Yu,Yanfang Xuan,Ayiguli Kari,Caixia Yang,Chenyu Wang,Chao Zhang,Wei Gu,Hui Wang,Yingxiong Hu,Pingdong Sun,Yuan Guan,Wenshuai Si,Bing Bai,Xuecai Zhang,Yunbi Xu,Boddupalli M. Prasanna,Biao Shi,Hongjian Zheng. 2023

[5]Enhancement of Waterlogging Tolerance and Improvement of Grain Quality in Waxy Maize With Exogenous EDAH: A Mixture of Ethephon and Diethyl Aminoethyl Hexanoate. Chao Huang,Xuchen Liu,Shoutian Ma,Anzhen Qin,Yingying Zhang,Yuxiang Xie,Yang Gao,Zhandong Liu. 2024

作者其他论文 更多>>