数字农科院2.0

Novel FSH receptor heterodimer may be related to the high prolificacy of Jintang black goat

文献类型： 外文期刊

作者： Ye Cao;Sujun Zhao;Mingxing Chu;Ran Di;Yufang Liu;Li Liu;Xueqin Zhang;Shaoping Qian;Yizheng Zhang

作者机构：

关键词： dimerization;FRET;FSHRA;FSHRB;in vitro maturation;Jintang black goat;prolificacy

期刊名称： Animal Research and One Health

ISSN： 2835-5075

年卷期： 2025 年 3 卷 1 期

页码：

收录情况： 无来源刊（2025版）

摘要： Follicle-stimulating hormone (FSH) is the central hormone of the mammalian reproductive system. It targets the FSH receptor (FSHR), a member of the G protein-coupled receptor family, to induce the FSH signal transduction. In the highly prolific Jintang black goat, gonadotropin level is not higher than that of Boer goat. However, two isoforms of FSHRs (FSHRA and FSHRB), generated from the alternative splicing of the same primary FSHR transcript, were expressed in the reproductive organs of Jintang black goat simultaneously. The mRNA level of FSHRB is 45.89, 3.80, and 13.81 times greater than that of FSHRA in the hypothalamus, pituitary, and ovary of the Jintang black goat, respectively. We found that FSHRA could interact with FSHRB protein, leading to augment of the FSH signaling transduction pathway. The enhancement of FSH signaling could increase the in vitro oocyte maturation rate. It implied that this might be the important reason for the high prolificacy in Jintang black goat.

分类号：

  • 相关文献

[1]Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. Seok, Seung-Hyeon,Lee, Woojong,Jiang, Li,Molugu, Kaivalya,Zheng, Aiping,Li, Yitong,Park, Sanghyun,Bradfield, Christopher A.,Xing, Yongna,Lee, Woojong,Xing, Yongna,Molugu, Kaivalya,Xing, Yongna,Bradfield, Christopher A.,Xing, Yongna,Jiang, Li.

[2]Split aptamer-based sandwich fluorescence resonance energy transfer assay for 19-nortestosterone. Bai, Wenhui,Zhu, Chao,Liu, Jinchuan,Yan, Mengmeng,Yang, Shuming,Chen, Ailiang,Bai, Wenhui,Zhu, Chao,Liu, Jinchuan,Yan, Mengmeng,Yang, Shuming,Chen, Ailiang.

[3]Melatonin enhances the in vitro maturation and developmental potential of bovine oocytes denuded of the cumulus oophorus. Zhao, Xue-Ming,Min, Jiang-Tao,Du, Wei-Hua,Hao, Hai-Sheng,Liu, Yan,Qin, Tong,Wang, Dong,Zhu, Hua-Bin,Min, Jiang-Tao.

[4]A protocol for in vitro maturation and fertilization of sheep oocytes. Wang, S,Liu, Y,Holyoak, GR,Evans, RC,Bunch, TD. 1998

[5]Efficiency of in vitro embryo production of yak (Bos grunniens) cultured in different maturation and culture conditions. Guo, Xian,Ding, Xuezhi,Pei, Jie,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping,Guo, Xian,Ding, Xuezhi,Pei, Jie,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping. 2012

[6]Advances in Oocyte Maturation In Vivo and In Vitro in Mammals. Yao Jiang,Yingting He,Xiangchun Pan,Penghao Wang,Xiaolong Yuan,Bin Ma. 2023

[7]Vitrification of bovine germinal vesicle oocytes significantly decreased the methylation level of their in vitro derived MII oocytes. Zhang, Peipei,Yang, Sha,Zhang, Hang,Hao, Haisheng,Du, Weihua,Wang, Jingjing,Hao, Tong,Zhu, Huabin,Umer, Saqib,Zhao, Xueming. 2022

[8]Stage-dependent changes in culture medium osmolality promote porcine oocyte maturation in vitro. Lixiang Liu,Yu Tang,Jing Shao,Bingfeng Fan,Yifeng Yang,Ying Zhang,Xiangyuan Zhao,Hailong Xue,Huimin Sun,Xulin Zhang,Yushi Zhang,Baozeng Xu. 2025

[9]The combination of FLI, ITS, pFF, and citrate improves the developmental potential of gilt oocytes during in vitro maturation. Zhilong Chen,Caiyong Zhang,Chao Yan,Cuiting Peng,Hao Xie,Yingting Pan,Lin Qi,Chaoqun Qu,Yulan Zhao,Zhonglin Tang. 2025

[10]Polymorphism in exon 2 of INHBB gene and its relationship with litter size in Jining Grey goats. Chu, M. X.,Fang, L.,Di, R.,Cao, G. L.,Feng, T.,Peng, Z. L.,Chen, H. Q.,Zhang, Y. J.,Li, N.. 2012

[11]Screening for S32G mutation of BMP15 gene in 18 goat breeds. Feng, Tao,Feng, Tao,Chu, Ming-Xing,Cao, Gui-Lin,Huang, Dong-Wei,Di, Ran,Liu, Qiu-Yue,Pan, Zhang-Yuan,Jin, Mei,Zhang, Ying-Jie. 2014

[12]Polymorphic Study of FecX(G), FecG(H) and Fec(B) Mutations in Four Domestic Sheep Breeds in the Lower Yellow River Valley of China. Zhang, Chuan-Sheng,Geng, Li-Ying,Du, Li-Xin. 2011

[13]Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries). Chu, M. X.,Liu, Z. H.,Jiao, C. L.,He, Y. Q.,Fang, L.,Ye, S. C.,Chen, G. H.,Wang, J. Y.. 2007

[14]The genetic diversity of both FecB gene and microsatellite GC101 is associated with reproduction selection in sheep. Pan, Zhangyuan,Hu, Wenping,Di, Ran,Lin, Qinyue,Wang, Xiangyu,Yin, Dehua,Chu, Mingxing,Zhang, Baoyun,Wang, Pingqing.

[15]Polymorphisms of KiSS-1 and GPR54 genes and their relationships with litter size in sheep. Chu, Mingxing,Feng, Tao,Cao, Guiling,Fang, Li,Di, Ran,Tang, Qianqian,Huang, Dongwei,Ma, Yuehui,Li, Kui,Xiao, Chaoting,Fu, Yan,Li, Ning.

[16]Polymorphisms of BMPR-IB gene and their relationship with litter size in goats. Chu, M. X.,Di, R.,Cao, G. L.,Feng, T.,Fang, L.,Ma, Y. H.,Li, K.,Zhao, X. H.,Wang, J. Y.,Zhang, Y. J.,Jin, M..

[17]Polymorphism of insulin-like growth factor 1 gene and its association with litter size in Small Tail Han sheep. He, J. N.,Chu, M. X.,Feng, T.,Di, R.,Fang, L.,Huang, D. W.,Tang, Q. Q.,Zhang, B. Y.,Wang, P. Q.,Cao, G. L.,Li, N..

[18]Polymorphisms of caprine POU1F1 gene and their association with litter size in Jining Grey goats. Feng, T.,Chu, M. X.,Cao, G. L.,Tang, Q. Q.,Di, R.,Fang, L.,Li, N..

[19]Polymorphism of Prophet of Pit-1 gene and its relationship with litter size of Small Tail Han sheep. Liu, Qiuyue,Chu, Mingxing,Di, Ran,Feng, Tao,Geng, Caixia,Chen, Hongquan,Jin, Mei,Zhang, Yingjie,Li, Ning. 2015

[20]Association between PCR-RFLP of melatonin receptor 1a gene and high prolificacy in Small Tail Han sheep. Chu, MX,Ji, CL,Chen, GH. 2003

作者其他论文 更多>>