数字农科院2.0

Phlorizin Alleviates Inflammation Caused by Deoxynivalenol by Regulating the Gut Microbiome and Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway in Mice

文献类型： 外文期刊

作者： Zhao T.;Jin J.;Huangfu B.;He X.;Zhang B.;Li X.;Xu W.;Xing F.

作者机构：

关键词： deoxynivalenol;gut microbial;gut-liver axis;inflammation;phlorizin

期刊名称： ACS Food Science and Technology

ISSN： 2692-1944

年卷期： 2024 年 4 卷 2 期

页码：

收录情况： 无来源刊（2024版）

摘要： Deoxynivalenol (DON) is a commonly seen mycotoxin that can cause various health problems, such as vomiting, growth retardation, and immunosuppression, in both humans and animals due to its ability to affect the gastrointestinal tract and the immune system. Phlorizin (PHZ) is a polyphenolic compound with anti-inflammatory and antioxidant effects that are present in apples. In this study, we explored the alleviating effects of PHZ against DON-induced adverse effects in mice. The results revealed that coexposure to DON and 200 mg/kg b.w. PHZ significantly alleviated DON-induced liver injury. Further results showed that PHZ upregulated the intestinal tight junction proteins (Claudin, Occludin, and ZO-1), improved intestinal permeability, and inhibited the liver TLR4/NF-κB signaling pathway. The latter may explain the alleviated liver inflammation. Analysis of 16S rRNA gene sequencing of intestinal microbiota revealed that PHZ coexposure prevented the intestinal microbiota imbalance caused by DON. PHZ coexposure also prevented an increase of the relative abundance of Bacteroides and Clostridia_UCG-014 and prevented the DON-induced decrease of beneficial bacteria (Duchenella and Roseburia). It is concluded that PHZ coexposure may prevent DON-induced gut and liver inflammation through multiple routines, including regulating intestinal microorganisms, restoring intestinal mucosal barrier function, and improving intestinal permeability. In conclusion, PHZ coadministration is promising to alleviate the toxicity of DON. © 2024 American Chemical Society

分类号：

  • 相关文献

[1]Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut-liver axis. Han, Hui,Jiang, Yi,Wang, Mengyu,Melaku, Mebratu,Liu, Lei,Zhao, Yong,Everaert, Nadia,Yi, Bao,Zhang, Hongfu. 2021

[2]Baicalin Alleviates Short-Term Lincomycin-Induced Intestinal and Liver Injury and Inflammation in Infant Mice. Zhang, Shunfen,Zhong, Ruqing,Tang, Shanlong,Han, Hui,Chen, Liang,Zhang, Hongfu. 2022

[3]Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease. Shumin Zhang,Jingwen Zhao,Fei Xie,Hengxun He,Lee J. Johnston,Xiaofeng Dai,Chaodong Wu,Xi Ma. 2021

[4]Synergistic risk in the gut and liver: Insights into the toxic mechanisms and molecular interactions of combined exposure to triazophos and fenvalerate in zebrafish. Xuehua An,Ruike Wang,Chong Cao,Dou Wang,Chen Chen,Yanhua Wang. 2024

[5]Decoding the role of the intestinal epithelium in hepatitis E virus infection using a human organoid prototype of “gut-liver” axis. Kuan Liu,Yang Wang,Jiangrong Zhou,Joy Joàn van der Meij,Luc J.W. van der Laan,Pengfei Li,Qiuwei Pan. 2025

[6]Effects of inactivated Bacillus sp. DU-106 on high-fat diet-induced obesity and the gut-liver axis. Li, Yanli,Zhao, Wenjun,Jiang, Bingyan,Huang, Xiao-Chun,Liu, Jie,Huang, Junyuan,Hu, Bang,Liu, Yong-Xin,Du, Bing,Li, Pan. 2025

[7]Heat-Inactivated Lactiplantibacillus plantarum FRT4 Alleviates Diet-Induced Obesity via Gut-Liver Axis Reprogramming. Huang, Yuyin,Wang, Qingya,Han, Xiling,Meng, Kun,Liu, Guohua,Zhang, Haiou,Zhang, Rui,Cai, Hongying,Yang, Peilong. 2025

[8]Metabolite-mediated crosstalk: unraveling the interactions between gut microbiota and host in fatty liver hemorrhagic syndrome of laying hens. Shaobo Zhang,Xinghua Zhao,Xin He,Wanyu Shi,Ning Ma. 2026

[9]Nettle (Urtica cannabina L.) polysaccharides as a novel dietary supplement: enhancing systemic antioxidant status via modulation of the gut-liver axis. Zhang, Jize,Zhang, Qian,Zhang, Xiaoqing,Qiao, Jiang,Wang, Jingwei,Gao, Yang,Dong, Ping. 2025

[10]A minor survey of deoxynivalenol in Fusarium infected wheat from Yangtze-Huaihe river basin region in China. Cui, Li,Selvaraj, Jonathan Nimal,Xing, Fuguo,Zhao, Yueju,Zhou, Lu,Liu, Yang. 2013

[11]Fates of deoxynivalenol and deoxynivalenol-3-glucoside during bread and noodle processing. Zhang, Huijie,Wang, Bujun,Zhang, Huijie,Wang, Bujun.

[12]Retention of deoxynivalenol and its derivatives during storage of wheat grain and flour. Zhang, Huijie,Sun, Juan,Zhang, Yan,Lu, Meibin,Sun, Lijuan,Li, Weixi,Hu, Xuexu,Wang, Bujun,Zhang, Huijie,Sun, Juan,Zhang, Yan,Lu, Meibin,Sun, Lijuan,Li, Weixi,Hu, Xuexu,Wang, Bujun.

[13]Evaluation on levels and conversion profiles of DON, 3-ADON, and 15-ADON during bread making process. Wang, Bujun.

[14]Effects of feeding a Fusarium toxin-contaminated diet to infectious bursal disease virus-infected broilers on the protein turnover of the bursa of Fabricius and spleen. Daenicke, Sven,Pappritz, Julia,Goyarts, Tanja,Xu, Bu,Rautenschlein, Silke. 2011

[15]Occurrence of mycotoxins in feed ingredients and complete feeds obtained from the Beijing region of China. Zhao, Lihong,Fan, Yu,Ma, Shanshan,Ji, Cheng,Ma, Qiugang,Zhang, Jianyun,Jia, Yaxiong,Sun, Lei.

[16]Limited survey of deoxynivalenol in wheat from different crop rotation fields in Yangtze-Huaihe river basin region of China. Selvaraj, Jonathan Nimal,Zhao, Yueju,Sangare, Lancine,Xing, Fuguo,Zhou, Lu,Wang, Yan,Liu, Yang,Xue, Xiaofeng,Li, Yi,Xue, Xiaofeng,Li, Yi.

[17]Fate of deoxynivalenol and deoxynivalenol-3-glucoside during wheat milling and Chinese steamed bread processing. Zhang, Huijie,Wang, Bujun,Zhang, Huijie,Wang, Bujun. 2014

[18]Phosphoproteome Analysis Reveals the Molecular Mechanisms Underlying Deoxynivalenol-Induced Intestinal Toxicity in IPEC-J2 Cells. Zhang, Zhi-Qi,Wang, Rui-Guo,Zhang, Wei,Wang, Pei-Long,Su, Xiao-Ou,Wang, Song-Bo,Wang, Song-Bo. 2016

[19]Regulation Of The Phytotoxic Response Of Arabidopsis Thaliana To The Fusarium Mycotoxin Deoxynivalenol. Wang, Y, Yan, H, Wang, Q, Zheng, R, Xia, K, Liu, Y. 2020

[20]The Antagonistic Effect Of Mycotoxins D.eoxynivalenol And Zearalenone On M etabolic Profiling In Serum And Liver Of Mice. Ji, J, Zhu, P, Cui, FC, Pi, FW, Zhang, YZ, Li, Y, Wang, JS, Sun, XL. 2017

作者其他论文 更多>>