数字农科院2.0

In-house ammonia induced lung impairment and oxidative stress of ducks

文献类型： 外文期刊

作者： Bo Liu;Yongjie Yang;Yang Fu;Yue Zhao;Wenjing Chen;Shi Wei;Xin Zuo;Yongwen Zhu;Hui Ye;Minhong Zhang;Peng Zhang;Lin Yang;Wence Wang;Jie Pan

作者机构：

关键词： ammonia;duck;growth performance;lung;trachea

期刊名称： Poultry Science

ISSN： 0032-5791

年卷期： 2024 年 103 卷 5 期

页码：

收录情况： SCIE（2024版）

摘要： Ammonia (NH3) is a toxic gas that in intensive poultry houses, damages the poultry health and induces various diseases. This study investigated the effects of NH3 exposure (0, 15, 30, and 45 ppm) on growth performance, serum biochemical indexes, antioxidative indicators, tracheal and lung impairments in Pekin ducks. A total of 288 one-day-old Pekin male ducks were randomly allocated to 4 groups with 6 replicates and slaughtered after the 21-d test period. Our results showed that 45 ppm NH3 significantly reduced the average daily feed intake (ADFI) of Pekin ducks. Ammonia exposure significantly reduced liver, lung, kidney, and heart indexes, and lowered the relative weight of the ileum. With the increasing of in-house NH3, serum NH3 and uric acid (UA) concentrations of ducks were significantly increased, as well as liver malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX-Px) contents. High NH3 also induced trachea and lung injury, thereby increasing levels of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) in the lung, and decreasing the mRNA expressions of zonula occludens 1 (ZO-1) and claudin 3 (CLDN3) in the lung. In conclusion, in-house NH3 decrease the growth performance in ducks, induce trachea and lung injuries and meanwhile increase the compensatory antioxidant activity for host protection.

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