数字农科院2.0

Boosting chemotherapy of bladder cancer cells by ferroptosis using intelligent magnetic targeting nanoparticles

文献类型： 外文期刊

作者： Cai X.;Ruan L.;Wang D.;Zhang J.;Tang J.;Guo C.;Dou R.;Zhou M.;Hu Y.;Chen J.

作者机构：

关键词： Immunotherapy;Lipid peroxidation;Macrophage;Reactive oxygen species;Superparamagnetic iron oxide nanoparticles;Tumor of bladder

期刊名称： Colloids and Surfaces B: Biointerfaces

ISSN： 0927-7765

年卷期： 2024 年 234 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： A versatile nano-delivery platform was reported to enhance the tumor suppression effect of chemotherapy by augmenting tumor cells' ferroptosis. The platform consists of pomegranate-like magnetic nanoparticles (rPAE@SPIONs) fabricated by encapsulating superparamagnetic iron oxide nanoparticles (SPIONs) within a reduced poly(β-amino ester)s-PEG amphiphilic copolymer (rPAE). The resulting platform exhibits several functionalities. Firstly, it promotes the doxorubicin (DOX) release by leveraging the mild hyperthermia generated by NIR irradiation. Secondly, it triggers ferroptosis in tumor cells, inducing their demise. Thirdly, it induces polarization of macrophages towards an anti-tumor M1 phenotype, contributing to ferroptosis of tumor cells and enhanced tumor cell suppression. This study effectively capitalizes on the versatility of SPIONs and offers a simple yet powerful strategy for developing a new nanosized ferroptosis-inducing agent, ultimately improving the inhibition of bladder cancer cells. © 2023 Elsevier B.V.

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