数字农科院2.0

Mechanism of polyphenol-pea starch complexes on reducing fat accumulation in Caenorhabditis elegans

文献类型： 外文期刊

作者： Dan Luo;Wei Wang;Manqin Jin;Xuemei Zhang;Jiaxing Fan;Yingkang Yang;Chen Zhai;Huan Rao;Wentong Xue

作者机构：

关键词： Caenorhabditis elegans;Lipid-lowering effect;MDT-15;Pea starch;Polyphenol-starch complexes;ROS

期刊名称： Food Research International

ISSN： 0963-9969

年卷期： 2025 年 209 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Obesity is characterized by lipid metabolism disorders and excessive fat accumulation, imposing a significant burden on individuals and society. Polyphenol-pea starch (PS) complexes have shown considerable potential in alleviating fat accumulation, yet the mechanisms underlying these effects remain unclear. This study investigated the effects and underlying mechanisms of gallic acid-PS (GAL-PS), ferulic acid-PS (FER-PS), quercetin-PS (QUE-PS), and tannic acid-PS (TAN-PS) complexes at a dosage of 1 mg/mL in reducing fat accumulation in Caenorhabditis elegans. The results revealed that GAL-PS, FER-PS, QUE-PS, and TAN-PS complexes significantly reduced triglyceride content in high-fat C. elegans by 38.61 %, 10.81 %, 18.60 %, and 25.78 %, respectively. Additionally, these polyphenol-PS complexes reduced both the size and number of lipid droplets in ZXW618, which are mutant expressing the lipid droplet membrane protein dehydrogenase-3 linked to GFP, and increased the proportions of unsaturated fatty acids and antioxidant activities in high-fat worms. Mechanistically, polyphenol-PS complexes regulated multiple lipid metabolism pathways via MDT-15/SBP-1 and MDT-15/NHR-49 signaling pathways, which include fat-5, fat-6, and fat-7, pod-2, fasn-1, and elo-2 genes modulated fat synthesis, acs-2, aak-2, tub-1, and skn-1 genes participated in fat consumption, and tub-1, and vit-2 regulated fat storage. Our findings provide a novel perspective and theoretical foundation for the reducing fat accumulation by polyphenol starch-based food biomacromolecules and their potential applications in starchy foods.

分类号：

  • 相关文献

[1]活性氧在柠檬醛抑制黄曲霉产毒过程中的作用. 李金寒,商博,梁丹丹,Jonathan Nimal Selvaraj,鲁志松,刘阳. 2016

[2]活性氧(ROS)对牛卵母细胞体外成熟凋亡的影响. 刘涛,李向臣,浦亚斌,姚雅馨,关伟军,马月辉. 2010

[3]低氧适应的线粒体调控机制研究进展. 左清清,姚娜,董坤哲,叶绍辉,马月辉. 2013

[4]OsPHGPx基因的过量表达增强水稻抗氧化能力. 宋建辉,李甜,吴秀云,吴赴清,刘进元. 2014

[5]赭曲霉毒素A诱导Caco-2细胞的细胞毒性及DNA损伤. 张捷,李发弟,李爱军,郑楠,李松励,王加启. 2016

[6]烟草转录因子NtNAC080在非生物胁迫下的表达分析及功能鉴定. 文利超,熊涛,邓智超,刘涛,郭存,李伟,郭永峰. 2023

[7]AP2转录因子Oserf34正向调控水稻种子休眠. 杜志敏,贾一楠,段影青,曹妮,马刘洋,董欣丽,徐海,焦桂爱,唐绍清,胡培松. 2025

[8]弓形虫TR与ROP5双基因缺失株的构建及其生物学功能研究. 耿小玲,李瑞芳,徐卫兵,杜晶莹,张曼玉,孙卿,蒋蔚,米荣升,陈兆国,王权. 2025

[9]Selective Toxicity of Secondary Metabolites from the Entomopathogenic Bacterium Photorhabdus luminescens sonorensis against Selected Plant Parasitic Nematodes of the Tylenchina Suborder. Kusakabe A., 王辰., Xu Y.-M., Molnár I., Stock S.P.. 2022

[10]Antioxidant capacity of sesamol in Caenorhabditis elegans model system. Huang J.,Qi S.,Sun Q.,Song G.,Tang J.,Duan Y.. 2024

[11]Complexation temperature regulated the structure and digestibility of pea starch–gallic acid complexes during high pressure homogenization. Dan Luo,Ziqing Sang,Qiang Xie,Chen Chen,Zhaomin Wang,Chunhong Li,Wentong Xue. 2024

[12]Structural basis for the anti-aging effects of hydroxyproline-BCAA dipeptides: An integrated computational and experimental approach. Liu, Linggao,Wu, Ruiyun,Gao, Ziwu,Wang, Haijie,Xu, Anqi,Hou, Xinning,Zhang, Dequan,Wang, Zhenyu. 2025

[13]Uncovering key bioactive fatty acids from velvet antler extracts that promote healthspan and neuroprotection in Caenorhabditis elegans. Li, Ru,Yao, Yumin,Liu, Ying,Wang, Xiaohui,Li, Hongyuan,Liu, Yanfang,Peng, Yinghua. 2025

[14]Changes in starch-assisted expansion porous structure of peanut protein via extrusion and impact on textural and rehydration properties. Feng Guo,Hui Hu,Huan Zhou,Anna Hu,Qiang Wang,Jinchuang Zhang. 2025

[15]Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway. Wang, Congcong,Tang, Shusheng,Zhao, Dongxu,Zhang, Chaoming,Zhang, Shen,Deng, Sijun,Zhou, Yan,Xiao, Xilong,Wang, Congcong,Li, Tao.

[16]Influence of acrylamide on ROS, Hsp27 and NF-kappa B in bone marrow mesenchymal stem cells. Liu, Yang,Tao, Xiaoli,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Liu, Yang,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Liu, Yang,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Tao, Xiaoli.

[17]Maize ZmRAV1 contributes to salt and osmotic stress tolerance in transgenic arabidopsis. Min, Haowei,Wang, Jianhua,Zheng, Jun. 2014

[18]Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida). Liu, Tong,Wang, Xiuguo,Xu, Jinli,You, Xiangwei,Chen, Dan,Wang, Fenglong,Li, Yiqiang.

[19]Dose dependent rhizospheric Ni toxicity evaluation: Membrane stability and antioxidant potential of Vigna species. Mahmood, Seema,Ishtiaq, Shabnam,Yasin, Ghulam,Irshad, Ahsan. 2016

[20]Combined herbicide and saline stress differentially modulates hormonal regulation and antioxidant defense system in Oryza sativa cultivars. Islam, Faisal,Ali, Basharat,Wang, Jian,Farooq, Muhammad A.,Gill, Rafaqat A.,Zhou, Weijun,Islam, Faisal,Ali, Basharat,Wang, Jian,Farooq, Muhammad A.,Gill, Rafaqat A.,Zhou, Weijun,Ali, Shafaqat,Wang, Danying.

作者其他论文 更多>>