数字农科院2.0

The Transport and Uptake of Resveratrol Mediated via Glucose Transporter 1 and Its Antioxidant Effect in Caco-2 Cells

文献类型： 外文期刊

作者： Zhang, Zhen-Dong;Tao, Qi;Bai, Li-Xia;Qin, Zhe;Liu, Xi-Wang;Li, Shi-Hong;Yang, Ya-Jun;Ge, Wen-Bo;Li, Jian-Yong

作者机构：

关键词： resveratrol;Caco-2 cell;uptake;transport;metabolomics

期刊名称： MOLECULES

ISSN：

年卷期： 2023 年 28 卷 12 期

页码：

收录情况： SCIE（2023版）

摘要： Resveratrol has anti-inflammatory, anti-cancer, and anti-aging pharmacological activities. There is currently a gap in academic research regarding the uptake, transport, and reduction of H2O2-induced oxidative damage of resveratrol in the Caco-2 cell model. This study investigated the role of resveratrol in the uptake, transport, and alleviation of H2O2-induced oxidative damage in Caco-2 cells. In the Caco-2 cell transport model, it was observed that the uptake and transport of resveratrol (10, 20, 40, and 80 & mu;M) were time dependent and concentration dependent. Different temperatures (37 & DEG;C vs. 4 & DEG;C) could significantly affect the uptake and transportation of resveratrol. The apical to basolateral transport of resveratrol was markedly reduced by STF-31, a GLUT1 inhibitor, and siRNA intervention. Furthermore, resveratrol pretreatment (80 & mu;M) improves the viability of Caco-2 cells induced by H2O2. In a cellular metabolite analysis combined with ultra-high performance liquid chromatography-tandem mass spectrometry, 21 metabolites were identified as differentials. These differential metabolites belong to the urea cycle, arginine and proline metabolism, glycine and serine metabolism, ammonia recycling, aspartate metabolism, glutathione metabolism, and other metabolic pathways. The transport, uptake, and metabolism of resveratrol suggest that oral resveratrol could prevent intestinal diseases caused by oxidative stress.

分类号：

  • 相关文献

[1]Uptake and Transport of Naringenin and Its Antioxidant Effects in Human Intestinal Epithelial Caco-2 Cells. Zhang, Zhen-Dong,Tao, Qi,Qin, Zhe,Liu, Xi-Wang,Li, Shi-Hong,Bai, Li-Xia,Yang, Ya-Jun,Li, Jian-Yong. 2022

[2]Kinetics of manganese transport and gene expressions of manganese transport carriers in Caco-2 cell monolayers. Li, Xiaoli,Xie, Jingjing,Lu, Lin,Zhang, Liyang,Zhang, Lingyan,Luo, Xugang,Li, Xiaoli,Zou, Yaxue,Wang, Qiuyue,Li, Sufen.

[3]Absorption and transport mechanism of colloidal nanoparticles (CNPs) in lamb soup based on Caco-2 cell. Fu, Jianing,Li, Shaobo,Xu, Meizhen,Liu, Ling,Chen, Li,Zhang, Dequan. 2024

[4]Investigation of the Uptake and Transport of Aspirin Eugenol Ester in the Caco-2 Cell Model. Tao, Qi,Qin, Zhe,Liu, Xi-Wang,Zhang, Zhen-Dong,Li, Shi-Hong,Bai, Li-Xia,Li, Jian-Yong,Yang, Ya-Jun. 2022

[5]A pH-response nano pesticide delivery system based on ZIF-8: effectiveness, delivery and safety in mustard application. Fang, Nan,Jiang, Jinhua,Zhao, Xueping,Li, Yanjie,Wang, Xiangyun,Yu, Jianzhong,He, Hongmei,Zheng, Hongying,Yan, Fei,Li, Runan,Zhang, Changpeng. 2025

[6]Bacillus amyloliquefaciens Regulates the Keap1/Nrf2 Signaling Pathway to Improve the Intestinal (Caco-2 Cells and Chicken Jejunum) Oxidative Stress Response Induced by Lipopolysaccharide (LPS). Xing Chen,Aijuan Zheng,Shuzhen Li,Zedong Wang,Zhimin Chen,Jiang Chen,Zhiheng Zou,Haijun Liang,Guohua Liu. 2024

[7]Kiwifruits (Actinidia deliciosa) transformed with a Vitis stilbene synthase gene produce piceid (resveratrol-glucoside). Kobayashi, S,Ding, CK,Nakamura, Y,Nakajima, I,Matsumoto, R. 2000

[8]Optimisation for resveratrol accumulation during peanut germination with phenylalanine feeding & ultrasound-treatment using response surface methodology. Yu, Miao,Yu, Miao,Liu, Hongzhi,Yang, Ying,Shi, Aimin,Liu, Li,Hui, Hui,Wang, Qiang,Yu, Miao. 2016

[9]Preparation of resveratrol-enriched and poor allergic protein peanut sprout from ultrasound treated peanut seeds. Yu, Miao,Liu, Hongzhi,Shi, Aimin,Liu, Li,Wang, Qiang,Yu, Miao,Yu, Miao.

[10]Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells. Ou, Xiuyuan,Zhang, Xumeng,He, Qiyang,Ou, Xiuyuan,Zhang, Xumeng,He, Qiyang,Ou, Xiuyuan,Chen, Yan,Chen, Yan,Cheng, Xinxin,Cheng, Xinxin.

[11]Effect of dietary supplementation with resveratrol on nutrient digestibility, methanogenesis and ruminal microbial flora in sheep. Ma, T.,Chen, D. -D.,Tu, Y.,Zhang, N. -F.,Si, B. -W.,Diao, Q. -Y.,Deng, K. -D..

[12]Optimising germinated conditions to enhance yield of resveratrol content in peanut sprout using response surface methodology. Yu Miao,Liu Hong-zhi,Yang Ying,Shi Ai-min,Liu Li,Hu Hui,Wang Qiang,Yu Hong-wei,Yu Miao,Wang Xiao-he.

[13]Somatic embryos cultures of Vitis amurensis Rupr. in air-lift bioreactors for the production of biomass and resveratrol. Sun, Dan,Li, Changyu,Qin, Hongyan,Zhang, Qingtian,Yang, Yiming,Ai, Jun. 2016

[14]In Vitro Bioavailability Of Resveratrol E.ncapsulated In Liposomes: Influence O f Chitosan Coating And Liposome Compositions. Yang, Y, Liu, HZ, Shi, AM, Liu, L, Hu, H, Wang, Q. 2017

[15]Vitrification of bovine germinal vesicle oocytes significantly decreased the methylation level of their in vitro derived MII oocytes. Zhang, Peipei,Yang, Sha,Zhang, Hang,Hao, Haisheng,Du, Weihua,Wang, Jingjing,Hao, Tong,Zhu, Huabin,Umer, Saqib,Zhao, Xueming. 2022

[16]Identification and validation of a major locus with linked marker for resveratrol content in culitivated peanut. Jianbin Guo,Haiwen Chen,Nian Liu,Weigang Chen,Xiaojing Zhou,Huaiyong Luo,Li Huang,Weitao Li,Bei Wu,Dongxin Huai,Yong Lei,Boshou Liao,Huifang Jiang. 2022

[17]Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review. Wu, Si-Xia,Xiong, Ruo-Gu,Huang, Si-Yu,Zhou, Dan-Dan,Saimaiti, Adila,Zhao, Cai-Ning,Shang, Ao,Zhang, Yun-Jian,Gan, Ren-You,Li, Hua-Bin. 2022

[18]Hyaluronic acid-functionalized redox-responsive organosilica nanoparticles for targeted resveratrol delivery to attenuate acrylamide-induced toxicity. Dan Jiang,Xiaoyang Xia,Zhixiong He,Yanan Xue,Xia Xiang. 2023

[19]Biodegradable organosilica-based targeted and redox-responsive delivery system of resveratrol for efficiently alleviating ulcerative colitis. Jiang, Dan,Xia, Xiaoyang,He, Zhixiong,Xue, Yanan,Xiang, Xia. 2023

[20]Health Benefits And Molecular Mechanisms Of Resveratrol: A Narrative Review. Meng, X, Zhou, J, Zhao, CN, Gan, RY, Li, HB. 2020

作者其他论文 更多>>