数字农科院2.0

Helminth reshapes host gut microbiota and immunoregulation by deploying an antimicrobial program of innate immunity

文献类型： 外文期刊

作者： Yang Zou;Lixia Pu;Aijiang Guo;Yaqi Li;Yihui Liu;Yugui Wang;Yingying Ding;Xiaowei Du;Xiaola Guo;Shaohua Zhang;Xuepeng Cai;Shuai Wang

作者机构：

关键词： gut microbiota;Helminths;immunoregulation;macrophages

期刊名称： Gut Microbes

ISSN： 1949-0976

年卷期： 2025 年 17 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Helminths can manipulate their host’s gut microbiota, with the expansion of the lactobacilli population being a common feature. This process profoundly influences host immunoregulation, yet the underlying mechanisms remain almost unknown. Using a tissue-dwelling helminth model (larval Echinococcus multilocularis) while validating key findings from other helminth infections, we show that helminths harness the antibacterial program of host innate immunity to transform the host gut microbiome and control gut microbiota-mediated immunity. Using multifaceted techniques, we elucidate that cathelicidin-related antimicrobial peptide (CRAMP), derived from the expanded CD11b+CD206+ macrophages rather than the intestinal epithelial cells, is the key component that enters into the gut ecological system and enhances the fitness of Lactobacillus by selectively killing gram-negative microbes like enterobacteria. Furthermore, through in vitro cell culturing and in vivo dietary intervention experiments, we demonstrate that this regulation from innate immunity is boosted via toll-like receptor signaling by helminth’s secretory products, which could be sufficiently tuned down by dietary vitamin D through its receptor and cyp27b1. Importantly, using microbiota-targeted treatment methods, we prove that this signaling bolsters gut microbiota-mediated host intestinal Foxp3+ Treg cell expansion and parasite survival and that therapies targeting this signaling are effective in treating infection. We outline a dietary micronutrient-dependent mechanism by which helminths leverage host innate immunity to edit the host gut microbiome and thereby control immunosuppression precisely.

分类号：

  • 相关文献

[1]Lactobacillus acidophilus protects against Corynebacterium pseudotuberculosis infection by regulating the autophagy of macrophages and maintaining gut microbiota homeostasis in C57BL/6 mice. Li, Dengliang,Jiang, Yuecai,Cui, Zhanding,Ma, Mengzhen,Zhu, Fang,Li, Guanhua,Yang, Haoyue,Li, Shaofei,Zhang, Tianliang,Chen, Dekun,Ma, Wentao. 2024

[2]Echinococcus multilocularis serpin regulates macrophage polarization and reduces gut dysbiosis in colitis. Li, Xiaolu,Liu, Yihui,Zou, Yang,Zhang, Jiayun,Wang, Yugui,Ding, Yingying,Shi, Zhiqi,Guo, Xiaola,Zhang, Shaohua,Yin, Hong,Guo, Aijiang,Wang, Shuai. 2024

[3]ModulationofmousemacrophageproteomeinducedbyToxoplasmagondiitachyzoitesinvivo. ZhouDonghui,YuanZiguo,ZhaoFurong,LiHailong,ZhouYang,LinRuiqing,ZouFengcai,SongHuiqun,XuMinjun,andZhuXingquan. 2011

[4]Use of mitochondrial RNA genes for the differentiation of four Trichinella species by multiplex PCR amplification. Blaga, R.,Fu, BaoQuan,Le Rhun, D.,Le Naour, E.,Heckman, A.,Zocevic, A.,Boireau, P.,Liu, MingYuan.

[5]Advances in the study of helminth mitochondrial genomes and their associated applications. Jia WanZhong,Yan HongBin,Ni XingWei,Lou ZhongZi,Li HongMin,Cao Ping,Cai XuePeng. 2012

[6]Circulatory microRNAs in helminthiases: Potent as diagnostics biomarker, its potential role and limitations. Hanif Ullah,Yali Tian,Safia Arbab,Ka Li,Muhammad Inayat Ullah Khan,Sajid Ur Rahman,Abdul Qadeer,Nehaz Muhammad,Suleman,Inam Ul Hassan. 2022

[7]Expansion of Opportunistic Enteric Fungal Pathogens and Occurrence of Gut Inflammation in Human Liver Echinococcosis. Wang, Yugui,Guo, Aijiang,Liu, Zhongli,Zou, Yang,Zhu, Wenjun,Wu, Shile,Zhang, Shengying,Guo, Xiaola,Zhang, Shaohua,Pu, Lixia,Zhu, Xing-Quan,Zhu, Guan,Cai, Xuepeng,Wang, Shuai. 2022

[8]Roles And Applications Of Probiotic L.actobacillus Strains. Zhang, ZW,Lv, JL,Pan, L,Zhang, YG. 2018

[9]Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets. Dongxu Ming,Xincong Xu,Xianren Jiang,Yanpin Li,Wenjuan Sun,Jiangbo Xiang,Mingyuan Huang,Yu Pi,Xilong Li. 2024

[10]Fermented Purslane (Portulaca oleracea L.) Supplementation Enhances Growth and Immune Function Parallel to the Regulation of Gut Microbial Butyrate Production in Weaned Piglets. Lei Xu,Ge Gao,Zian Zhou,Zixi Wei,Wenjuan Sun,Yanpin Li,Xianren Jiang,Jingang Gu,Xilong Li,Yu Pi. 2024

[11]Longan Polysaccharide as Adjuvant for Cyclophosphamide-Induced Side Effects in Murine Model. Bai, Yajuan,Fan, Bei,Wang, Fengzhong,Zhang, Mingwei. 2025

[12]Outer Membrane Vesicles Attenuate Klebsiella pneumoniae Infection Injury by Affecting Macrophage Polarisation and Helper T Cell Differentiation. Wei Fan,Wei Wang,Lin Kong,Shifan Chen,Xinyu Zhang,Yilu Zhai,Bo Zhang,Yan Wang,Dazhuo Zhao,Xiukai Tang,Jiaqi Fu,Fuliang Sun. 2025

[13]Excretory/secretory proteome of 14-day schistosomula, Schistosoma japonicum. Cao, Xiaodan,Fu, Zhiqiang,Han, Qian,Lu, Ke,Li, Hao,Zhu, Chuangang,Hong, Yang,Lin, Jiaojiao,Lin, Jiaojiao,Zhang, Min,Han, Yanhui.

[14]Structural features and immunostimulating effects of three acidic polysaccharides isolated from Panax quinquefolius. Wang, Lijun,Yao, Yang,Sang, Wei,Yang, Xiushi,Ren, Guixing,Wang, Lijun.

[15]Proteomic alteration of equine monocyte-derived macrophages infected with equine infectious anemia virus. Du, Cheng,Liu, Hai-Fang,Lin, Yue-Zhi,Wang, Xue-Feng,Ma, Jian,Wang, Xiaojun,Zhou, Jian-Hua,Du, Cheng,Li, Yi-Jing,Zhou, Jian-Hua.

[16]Infection with equine infectious anemia virus vaccine strain EIAV(DLV121) causes no visible histopathological lesions in target organs in association with restricted viral replication and unique cytokine response. Liu, Qiang,Ma, Jian,Wang, Xue-Feng,Xiao, Fei,Li, Li-Jia,Zhang, Jiao-Er,Lin, Yue-Zhi,Du, Cheng,He, Xi-Jun,Wang, Xiaojun,Zhou, Jian-Hua,Zhou, Jian-Hua.

[17]The therapeutic potential for targeting CSE/H2S signaling in macrophages against Escherichia coli infection. Shaodong Fu,Zhenglei Wang,Xiangan Han,Yuanyuan Xu,Jinfeng Miao. 2023

[18]Rna‐seq analysis of influenza a virus‐induced transcriptional changes in mice lung and its possible implications for the virus pathogenicity in mice. Tianxin Ma,Abdou Nagy,Guanlong Xu,Lingxiang Xin,Danqi Bao,Chenyang Lu,Shiqi Niu,Zihua Wu,Chaochao Ren,Ting Zhang,Jianmei Yang,Qiaoyang Teng,Xuesong Li,Zejun Li,Qinfang Liu. 2021

[19]Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway. Yuhua Gao,Ningning Mi,Ying Zhang,Xiangchen Li,Weijun Guan,Chunyu Bai. 2022

[20]Modulation of Macrophage Polarization by Viruses: Turning Off/On Host Antiviral Responses. Shaoxiong Yu,Hailiang Ge,Su Li,Hua Ji Qiu. 2022

作者其他论文 更多>>