数字农科院2.0

Specific Hepatorenal Toxicity and Cross-Species Susceptibility of Eight Representative Pesticides

文献类型： 外文期刊

作者： Yue Liu;Ning Xu;Xinyu Song;Muchen Deng;Ranfeng Sun;Peilong Wang;Lidong Cao

作者机构：

关键词： biomarkers;cross-species comparison;hepatorenal toxicity;in vitro toxicology;pesticide

期刊名称： Toxics

ISSN： 2305-6304

年卷期： 2025 年 13 卷 11 期

页码：

收录情况： SCIE（2025版）

摘要： Chronic exposure to pesticides poses significant hepatorenal toxicity risks, yet a systematic comparison of their effects across species and tissues is lacking. In this study, we systematically evaluated the cytotoxicity of eight pesticides using human (CCC-HEL-1 hepatocytes; 293T renal cells) and rodent (IAR hepatocytes; NRK renal cells) cellular models. Our results showed substantial variations in potency, with chlorothalonil exhibiting the highest toxicity (IC50 = 32.55 mg/L in 293T cells) and chlorpyrifos the lowest (IC50 = 444.5 mg/L in 293T cells). Principal component analysis revealed distinct species- and tissue-specific response patterns, highlighting the unique resistance of NRK cells. Mechanistic investigations demonstrated organ-specific biomarker alterations, such as elevated hepatic ALP and suppressed renal KIM-1. Remarkably, the MRP2 transporter exhibited tissue-specific divergence, being significantly downregulated in renal cells (all 8 pesticides, p < 0.005) and most hepatic cells (7/8 pesticides, p < 0.05), while propiconazole uniquely upregulated it in hepatocytes (1.5-fold, p < 0.05). Collectively, these findings offer critical mechanistic insights into pesticide-specific toxicity and cross-species susceptibility, providing valuable data to improve human health risk assessment in food safety and toxicology.

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