数字农科院2.0

Comparative Efficacy of Zinc Oxide Nanoparticles and Citric Acid on Surgically Incised Wound in Rabbit

文献类型： 外文期刊

作者： Rizwan Abdul Aleem;Asad Khan;Shafqat Naeem;Muhammad Tahir Aleem;Iftikhar Ali Khan;Abdul Qadeer;Shakeel Ahmed;Sadaf Aslam;Ashar Mehfooz

作者机构：

关键词： Citric acid;Collagen;Rabbits;Wound healing;Zinc oxide nanoparticles

期刊名称： Pakistan Journal of Zoology

ISSN： 0030-9923

年卷期： 2025 年 57 卷 5 期

页码：

收录情况： 无来源刊（2025版）

摘要： The purpose of this study was to compare the effects of zinc oxide (ZnO) nanoparticle ointment and Citric acid on the rate of wound healing, dermis thickness, and collagen content. For this purpose, five live rabbits were used. In each rabbit, three wounds were created by surgery. Wound A was treated with ZnO nanoparticles, wound B with citric acid ointment, and wound C was washed with normal saline. The wound healing effects were checked by using an arbitrary scoring system at different time intervals: the contraction rate of wounds, wound healing times, and tissue tensile strengths. The ZnO nanoparticles were found to be significantly effective in term of wounds healing and re-epithelization, and collagen content. Histopathological investigation revealed that treatment with ZnO nanoparticles produced better dermis thickness than balm of citrus extract and regular saline. In conclusion, the wound treated with topical application of ointment of ZnO nanoparticle in rabbits enhances wound healing enclosure in a significant way, and this was ascertained by histological study.

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