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H5N1 avian influenza virus PB2 antagonizes duck IFN-β signaling pathway by targeting mitochondrial antiviral signaling protein

文献类型： 外文期刊

作者： Zuxian Chen;Bingbing Zhao;Yingying Wang;Yuqing Du;Siyu Feng;Junsheng Zhang;Luxiang Zhao;Weiqiang Li;Yangbao Ding;Peirong Jiao

作者机构：

关键词： avian influenza virus;duck;mitochondrial antiviral signaling protein;polymerase basic 2;type I interferon

期刊名称： Journal of Integrative Agriculture

ISSN： 2095-3119

年卷期： 2025 年 24 卷 9 期

页码：

收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版） ; ; 农林核心（2024版）

摘要： Type I interferon (IFN)-mediated innate immune responses represent the first line of host defense against viral infection. However, the molecular mechanisms by which avian influenza virus (AIV) inhibits type I IFN production in ducks are not well understood. Here, we first found that the polymerase basic 2 (PB2) protein of H5N1 subtype AIV inhibited the type I IFN responses by targeting duck mitochondrial antiviral signaling protein (MAVS). We further demonstrated that H5N1-PB2 bound to the Δtransmembrane (ΔTM) domain of duck MAVS, and the polymerase basic 1 (PB1) binding domain (PBD) and RNA binding nuclear import domain (RND) of H5N1-PB2 interacted with MAVS to inhibit type I IFN expression in ducks. Collectively, our findings contribute to understanding the molecular mechanism by which AIV proteins regulate the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling pathway to evade host antiviral immune responses in ducks.

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