数字农科院2.0

Isolation and Characterization of a Duck Hepatitis A Virus Type 3 SH52 Strain in Ducklings

文献类型： 外文期刊

作者： Minfan Huang;Dun Shuo;Yifei Xiong;Mei Tang;Yufei Wang;Xue Pan;Chunxiu Yuan;Qinfang Liu;Zhifei Zhang;Qiaoyang Teng;Bangfeng Xu;Xiaona Shi;Minghao Yan;Peirong Jiao;Zejun Li;Dawei Yan

作者机构：

关键词： duck hepatitis A virus type 3;pathogenicity;phylogenetic analysis

期刊名称： Microorganisms

ISSN：

年卷期： 2025 年 13 卷 12 期

页码：

收录情况： SCIE（2025版）

摘要： Duck hepatitis A virus type 3 (DHAV-3), an avian-specific pathogen primarily impacting ducklings, poses a significant threat to the duck farming industry by causing high mortality rates. A DHAV-3 strain SH52 was isolated from the diseased ducks and phylogenetic analysis of the whole genome revealed that the DHAV-3 SH52 belongs to the prevalent strains in China. The DHAV-3 SH52 strain replicates at high levels in various organs of 8-day-old specific pathogen-free (SPF) shelducks, causing pathological damage and leading to high lethality in 8-day-olds following intramuscular infection. The findings of this study provide an ideal animal challenge model for evaluating the efficacy of DHAV-3 vaccines in the future.

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