数字农科院2.0

Tissue-resident, memory CD8(+) T cells are effective in clearing intestinal Eimeria falciformis reinfection in mice

文献类型： 外文期刊

作者： Shi, Fangyun;Zhang, Sixin;Zhang, Ning;Yu, Ying;Sun, Pei;Tang, Xinming;Liu, Xianyong;Suo, Xun

作者机构：

关键词： Eimeria falciformis;resident memory T cell;intestinal immunity;Apicomplexa pathogen;protective immunity

期刊名称： FRONTIERS IN IMMUNOLOGY

ISSN： 1664-3224

年卷期： 2023 年 14 卷

页码：

收录情况： SCIE（2023版）

摘要： Eimeria, a cousin of malarial parasites, causes coccidiosis that results in huge losses in the poultry industry. Although live coccidiosis vaccines have been developed and used widely for the successful control of the disease, the mechanism underlying protective immunity remains largely unknown. Using Eimeria falciformis as a model parasite, we observed that tissue-resident memory CD8(+) T (Trm) cells accumulated in cecal lamina propria following E. falciformis infection in mice, especially after reinfection. In convalescent mice challenged with a second infection, E. falciformis burden diminished within 48-72 h. Deep-sequencing revealed that CD8(+) Trm cells were characterized by rapid up-regulation of effector genes encoding pro-inflammatory cytokines and cytotoxic effector molecules. While FTY720 (Fingolimod) treatment prevented the trafficking of CD8(+) T cells in peripheral circulation and exacerbated primary E. falciformis infection, such treatment had no impact on the expansion of CD8(+) Trm cells in convalescent mice receiving secondary infection. Adoptive transfer of cecal CD8(+) Trm cells conferred immune protection in naive mice, indicating that these cells provide direct and effective protection against infection. Overall, our findings not only explain a protective mechanism of live oocyst-based anti-Eimeria vaccines but also provide a valuable correlate for assessing vaccines against other protozoan diseases.

分类号：

  • 相关文献

[1]Antibiotic Changes Host Susceptibility to Eimeria falciformis Infection Associated with Alteration of Gut Microbiota. Gong, Yujiao,Liu, Xianyong,Zhang, Sixin,Tang, Xinming,Zou, Jun,Suo, Xun. 2022

[2]Eimeria falciformis secretes extracellular vesicles to modulate proinflammatory response during interaction with mouse intestinal epithelial cells. Joshua Seun Olajide,Ling Xiong,Shunli Yang,Zigang Qu,Xiao Xu,Bin Yang,Jing Wang,Baohong Liu,Xueting Ma,Jianping Cai. 2022

[3]Quantitative proteomic analysis of local and systemic extracellular vesicles during Eimeria falciformis infectious cycle in the host. Joshua Seun Olajide,Zigang Qu,Shunli Yang,Bin Yang,Xiao Xu,Jing Wang,Jianping Cai. 2023

[4]Yellow mealworm (Tenebrio Molitor) enhances intestinal immunity in largemouth bass (Micropterus salmoides) via the NFκB/survivin signaling pathway. Chunyu Ge,Xiaofang Liang,Xiaoliang Wu,Jie Wang,Hao Wang,Yuchang Qin,Min Xue. 2023

[5]Influence of fermented feed additive on gut morphology, immune status, and microbiota in broilers. Peng, Wentong,Talpur, Mir Zulqarnain,Zeng, Yuxian,Xie, Peipei,Li, Jincheng,Wang, Songbo,Wang, Lina,Zhu, Xiaotong,Gao, Ping,Jiang, Qingyan,Shu, Gang,Zhang, Haijun. 2022

[6]Functional characterization of MEKK3 in the intestinal immune response to bacterial challenges in grass carp (Ctenopharyngodon idella). Qu, Fufa,Zeng, Xuan,Liu, Zhenzhen,Guo, Meixing,Zhang, Xia,Cao, Shenping,Zhou, Yonghua,He, Zhimin,Tang, Jianzhou,Mao, Zhuangwen,Yang, Yalin,Zhou, Zhigang,Liu, Zhen. 2022

[7]Xylooligosaccharide-mediated gut microbiota enhances gut barrier and modulates gut immunity associated with alterations of biological processes in a pig model. Shanlong Tang,Yuxia Chen,Fuli Deng,Xiaowei Yan,Ruqing Zhong,Qingshi Meng,Lei Liu,Yong Zhao,Sheng Zhang,Liang Chen,Hongfu Zhang. 2022

[8]The ratios of dietary non-fibrous carbohydrate (NFC) to neutral detergent fiber (NDF) influence intestinal immunity of rabbits by regulating gut microbiota composition and metabolites. Li, Shuo,Liu, Tingting,Wang, Kun,Li, Chong,Wu, Fengyang,Yang, Xinyu,Zhao, Man,Chen, Baojiang,Chen, Xiang. 2023

[9]Characterization and functional analysis of a novel C1q domain-containing protein from grass carp (Ctenopharyngodon idella) in response to bacterial challenge. Xia Zhang,Ran Peng,Fufa Qu,Meixing Guo,Ting Wu,Hao He,Yuhan Zhang,Kelan Jin,Jianzhou Tang,Yalin Yang,Zhigang Zhou,Junde Fan,Jianzhong Li,Zhen Liu. 2024

[10]Fish decay-accelerating factor (DAF) regulates intestinal complement pathway and immune response to bacterial challenge. Xia Zhang,Yuhan Zhang,Ting Wu,Hao He,Ran Peng,Kelan Jin,Huilan Mo,Fufa Qu,Jianzhou Tang,Yonghua Zhou,Yalin Yang,Zhigang Zhou,Junde Fan,Jianzhong Li,Zhen Liu. 2024

[11]Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model. Yuan, Zi-Guo,Ren, Di,Zhou, Dong-Hui,Zhou, Yang,Zhu, Xing-Quan,Yuan, Zi-Guo,Ren, Di,Zhang, Xiu-Xiang,Li, Xiu-Zhen,Petersen, Eskild,Petersen, Eskild,Yang, Gui-Lian,Zhu, Xing-Quan. 2013

[12]Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3. Zhang, Nian-Zhang,Huang, Si-Yang,Zhou, Dong-Hui,Chen, Jia,Zhu, Xing-Quan,Xu, Ying,Zhu, Xing-Quan,Tian, Wei-Peng,Lu, Jing,Zhu, Xing-Quan. 2013

[13]DNA vaccination with genes encoding Toxoplasma gondii antigens ROP5 and GRA15 induces protective immunity against toxoplasmosis in Kunming mice. Chen, Jia,Li, Zhong-Yuan,Huang, Si-Yang,Zhou, Dong-Hui,Zhu, Xing-Quan,Li, Zhong-Yuan,Zhu, Xing-Quan,Petersen, Eskild,Zhu, Xing-Quan. 2015

[14]DNA immunization with eukaryotic initiation factor-2 alpha of Toxoplasma gondii induces protective immunity against acute and chronic toxoplasmosis in mice. Chen, Jia,Huang, Si-Yang,Zhou, Dong-Hui,Li, Zhong-Yuan,Song, Hui-Qun,Zhu, Xing-Quan,Petersen, Eskild,Petersen, Eskild,Zhu, Xing-Quan. 2013

[15]Toxoplasma gondii: Protective immunity induced by rhoptry protein 9 (TgROP9) against acute toxoplasmosis. Chen, Jia,Zhou, Dong-Hui,Li, Zhong-Yuan,Huang, Si-Yang,Song, Hui-Qun,Zhu, Xing-Quan,Petersen, Eskild,Petersen, Eskild,Li, Zhong-Yuan,Zhu, Xing-Quan. 2014

[16]Protective efficacy of two novel DNA vaccines expressing Toxoplasma gondii rhomboid 4 and rhomboid 5 proteins against acute and chronic toxoplasmosis in mice. Zhang, Nian-Zhang,Xu, Ying,Wang, Meng,Chen, Jia,Huang, Si-Yang,Zhu, Xing-Quan,Xu, Ying,Petersen, Eskild,Huang, Si-Yang,Zhu, Xing-Quan. 2015

[17]Protective efficacy of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice. Chen, Jia,Li, Zhong-Yuan,Huang, Si-Yang,Song, Hui-Qun,Zhou, Dong-Hui,Zhu, Xing-Quan,Chen, Jia,Zhu, Xing-Quan,Petersen, Eskild,Petersen, Eskild. 2014

[18]Protection of Chickens against Very Virulent Marek's Disease Virus (MDV) by an Infectious Clone of Meq-Null MDV Vaccination. Cui, Ning,Su, Shuai,Cui, Zhizhong,Sun, Peng,Li, Yanpeng,Zhu, Hongfei,Ding, Jiabo,Kang, Mengjiao.

[19]Co-administration of interleukins 7 and 15 with DNA vaccine improves protective immunity against Toxoplasma gondii. Chen, Jia,Li, Zhong-Yuan,Liu, Wen-Ge,Zhu, Xing-Quan,Chen, Jia,Petersen, Eskild,Zhu, Xing-Quan.

[20]Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Wang, Gang,Song, Tengfei,Liu, Yonggang,Shi, Wenda,Wang, Shujie,Rong, Fulong,Dong, Jianguo,Liu, He,Cai, Xuehui,Wang, Gang,Song, Tengfei,Yu, Ying,Zhou, En-Min,Zhou, En-Min.

作者其他论文 更多>>