数字农科院2.0

Identification of Major Loci and Candidate Genes for Meat Production-Related Traits in Broilers

文献类型： 外文期刊

作者： Yang Xinting;Sun Jiahong;Zhao Guiping;Li Wei;Tan Xiaodong;Zheng Maiqing;Feng Furong;Liu Dawei;Wen Jie;Liu Ranran

作者机构：

关键词： candidate genes; carcass composition; genome-wide association study; imputation; thigh meat; weight trait

期刊名称： Frontiers in Genetics

ISSN： 1664-8021

年卷期： 2021 年 12 卷

页码：

收录情况： JCR（2021版）

摘要： Background: Carcass traits are crucial characteristics of broilers. However, the underlying genetic mechanisms are not well understood. In the current study, significant loci and major-effect candidate genes affecting nine carcass traits related to meat production were analyzed in 873 purebred broilers using an imputation-based genome-wide association study. Results: The heritability estimates of nine carcass traits, including carcass weight, thigh muscle weight, and thigh muscle percentage, were moderate to high and ranged from 0.21 to 0.39. Twelve genome-wide significant SNPs and 118 suggestively significant SNPs of 546,656 autosomal variants were associated with carcass traits. All SNPs for six weight traits (body weight at 42 days of age, carcass weight, eviscerated weight, whole thigh weight, thigh weight, and thigh muscle weight) were clustered around the 24.08 Kb region (GGA24: 5.73–5.75 Mb) and contained only one candidate gene (DRD2). The most significant SNP, rs15226023, accounted for 4.85–7.71% of the estimated genetic variance of the six weight traits. The remaining SNPs for carcass composition traits (whole thigh percentage and thigh percentage) were clustered around the 42.52 Kb region (GGA3: 53.03–53.08 Mb) and contained only one candidate gene (ADGRG6). The most significant SNP in this region, rs13571431, accounted for 11.89–13.56% of the estimated genetic variance of two carcass composition traits. Some degree of genetic differentiation in ADGRG6 between large and small breeds was observed. Conclusion: We identified one 24.08 Kb region for weight traits and one 42.52 Kb region for thigh-related carcass traits. DRD2 was the major-effect candidate gene for weight traits, and ADGRG6 was the major-effect candidate gene for carcass composition traits. Our results supply essential information for causative mutation identification of carcass traits in broilers. © Copyright © 2021 Yang, Sun, Zhao, Li, Tan, Zheng, Feng, Liu, Wen and Liu.

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