数字农科院2.0

From bioprocess to market: Optimizing medium-chain carboxylate extraction for application readiness

文献类型： 外文期刊

作者： Zhang, Yiran;Wang, Aijie;Sun, Yilu;Zhang, Xuening;Liu, Jianfeng;Wang, Wen;Huang, Cong;Fu, Shaoping;Deng, Honggang;Shan, Yongping;Yu, Jiadong;Yuan, Xufeng;Cui, Zongjun;Liu, Bin

作者机构：

关键词： Carboxylate platform;n-caproate;n-caprylate;Microbial chain elongation;Separation and purification;Industrial application

期刊名称： BIORESOURCE TECHNOLOGY

ISSN： 0960-8524

年卷期： 2025 年 442 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The carboxylate platform represents an emerging biotechnology for the sustainable valorization of organic waste into medium-chain carboxylates (MCCs), which are produced via anaerobic microbial chain elongation. While industrial-scale MCCs production is underway, broader commercialization is hindered by inefficiencies in chain elongation and the high cost of downstream processing. This review systematically assesses recent advances from metabolic pathways to extraction techniques, and further identifies operational optimization and in situ product recovery as critical levers for economic feasibility. Techniques such as membrane electrolysis and liquid-liquid extraction show particular promise when integrated directly into fermentation, enhancing both product titer and selectivity. To propel the field forward, this review emphasizes the need for intelligent bioprocess monitoring, bacterial strain engineering, and the translation of integrated fermentation-separation systems from lab to industrial practice. Ultimately, achieving commercially viable MCCs production will require synergistic advances across biological and engineering fronts.

分类号：

  • 相关文献

[1]Separation and Purification of Astragalus membranaceus Polysaccharides by Deep Eutectic Solvents-Based Aqueous Two-Phase System. Liu, Bangfu,Tan, Zhijian. 2022

[2]A salt/salt aqueous two-phase system based on pH-switchable deep eutectic solvent for the extraction and separation of mulberry polysaccharides. Lei, Tian,Qin, Zongkui,Liu, Leilei,Tan, Zhijian. 2024

[3]Isolation and Evaluation of Erinacine A Contents in Mycelia of Hericium erinaceus Strains. Mengchen Liu,Liangliang Liu,Xiaoya Song,Yingjun Zhou,Yuande Peng,Chunliang Xie,Wenbing Gong. 2024

[4]Cloning, purification and biochemical characterisation of an organic solvent-, detergent-, and thermo-stable amylopullulanase from Thermococcus kodakarensis KOD1. Guan, Qingtian,Guo, Xiaohan,Han, Ting,Wei, Mengwei,Zeng, Fan,Liu, Lin,Li, Zhe,Wang, Yuhan,Zhang, Shihong,Jia, Baolei,Jin, Meiling,Cheong, Gang-Won. 2013

[5]Gene cloning and enzymatic characterization of alkali-tolerant type I pullulanase from Exiguobacterium acetylicum. Qiao, Y.,Peng, Q.,Yan, J.,Wang, H.,Ding, H.,Shi, B..

[6]Improvement of thermostability and catalytic efficiency of glucoamylase from Talaromyces leycettanus JCM12802 via site-directed mutagenesis to enhance industrial saccharification applications. Lige Tong,Jie Zheng,Xiao Wang,Xiaolu Wang,Huoqing Huang,Haomeng Yang,Tao Tu,Yuan Wang,Yingguo Bai,Bin Yao,Huiying Luo,Xing Qin. 2021

[7]Recognition of Gallotannins and the Physiological Activities: From Chemical View. He, Hua-Feng. 2022

[8]Recent Advances in Microbial Synthesis of Poly-γ-Glutamic Acid: A Review. Danfeng Li,Lizhen Hou,Yaxin Gao,Zhiliang Tian,Bei Fan,Fengzhong Wang,Shuying Li. 2022

[9]Propolis as a promising functional ingredient: a comprehensive review on extraction, bioactive properties, bioavailability, and industrial applications. Liu, Mengyao,Li, Xiangxin,Chen, Hualei,Pan, Fei,Zheng, Xing,Battino, Maurizio,Tian, Wenli,Peng, Wenjun. 2025

作者其他论文 更多>>