数字农科院2.0

Lactobacillus plantarum L11 and Lactobacillus reuteri LR: Ameliorate Obesity via AMPK Pathway

文献类型： 外文期刊

作者： Shukun Liang;Jintao Sun;Xinshu Gu;Ya Zhao;Xiumin Wang;Hui Tao;Zhenlong Wang;Yougang Zhong;Jinquan Wang;Bing Han

作者机构：

关键词： gut microbiota;lipid metabolism;mechanism;probiotics

期刊名称： Nutrients

ISSN： 2072-6643

年卷期： 2025 年 17 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Objectives: The purpose of this study was to find the potential mechanism of two Lactobacillus (Lactobacillus plantarum L11 and Lactobacillus reuteri LR) on ameliorating obesity, including lipid metabolism and gut microbiota. The two isolates have been studied to have good characterization in vitro, but in vivo studies in modulating lipid metabolism and gut microbiota were not studied. Methods: In this study, mice with HFD supplemented with L11 or LR exhibited slower obesity progression, including reduced weight gain, abdominal fat accumulation, liver damage, inflammation, and adipose lesions. Results: Total cholesterol (TC) and triglycerides (TG) in the serum were significantly reduced (p < 0.01). The inflammatory marker interleukin-6 (IL-6) notably decreased (p < 0.05). Both Lactobacillus strains altered the gut microbiota composition, increasing the relative abundance of Alistipes and Lactobacillus, while L11 also raised Lachnospiraceae abundance. Results of the Western blot analysis showed that L11 and LR influenced the PPAR and AMPK pathways. Conclusions: L11 and LR can effectively reduce obesity by modulating gut microbiota and activating the PPAR–AMPK pathway, leading to decreased liver injury and systemic inflammation in mice fed with an HFD. In the future, the two probiotics may provide a new way for clinically ameliorating obesity on human beings.

分类号：

  • 相关文献

[1]Editorial: Gut Microbial Response to Host Metabolic Phenotypes. Jie Yin,Yong Su,Hui Han. 2022

[2]Effects and mechanisms of probiotics, prebiotics, synbiotics, and postbiotics on metabolic diseases targeting gut microbiota: A narrative review. Hang Yu Li,Dan Dan Zhou,Ren You Gan,Si Yu Huang,Cai Ning Zhao,Ao Shang,Xiao Yu Xu,Hua Bin Li. 2021

[3]Utilizing Lactic Acid Bacteria to Improve Hyperlipidemia: A Comprehensive Analysis from Gut Microbiota to Metabolic Pathways. Changlu Ma,Chen Xu,Mumin Zheng,Shuwen Zhang,Qifeng Liu,Jiaping Lyu,Xiaoyang Pang,Yinghong Wang. 2024

[4]Lacticaseibacillus rhamnosus G7 alleviates DSS-induced ulcerative colitis by regulating the intestinal microbiota. Jianlong Lao,Man Chen,Shuping Yan,Han Gong,Zhaohai Wen,Yanhong Yong,Dan Jia,Shuting Lv,Wenli Zou,Junmei Li,Huiming Tan,Hong Yin,Xiangying Kong,Zengyuan Liu,Fucheng Guo,Xianghong Ju,Youquan Li. 2025

[5]Protective effect of a newly probiotic Lactobacillus reuteri LY2-2 on DSS-induced colitis. Yang, Yong,Qiao, Yuyu,Liu, Ge,Yi, Gaoqin,Liu, Hongli,Zhang, Ting,Tong, Mingwei. 2025

[6]Bacillus subtilis HGCC-1 improves growth performance and liver health via regulating gut microbiota in golden pompano. Li, Ming,Liang, Hui,Zhang, Jian,Chen, Jie,Xu, Shichang,Zhou, Wenhao,Ding, Qianwen,Yang, Yalin,Zhang, Zhen,Yao, Yuanyuan,Ran, Chao,Zhou, Zhigang. 2025

[7]Isolation of Bacillus altitudinis A7 from Eimeria-immunized chickens and its inhibitory effect on Eimeria tenella. Zhongchuang Wang,Peiyao Shang,Man Lei,Wenjie Zhang,Ruiting Zhang,Qiping Zhao,Shunhai Zhu,Hongyu Han,Hui Dong,Lili Hao,Xingju Song. 2025

[8]Targeted gut microbiome therapy: Applications and prospects of probiotics, fecal microbiota transplantation and natural products in the management of type 2 diabetes. Luqi Qin,Bei Fan,Yixia Zhou,Jiahuan Zheng,Rao Diao,Fengzhong Wang,Jiameng Liu. 2025

[9]黄金梨黑心病形成机理及防控技术研究. 王文辉,王志华,佟伟,张志云,姜修成,贾晓辉. 2008

[10]Clostridium autoethanogenum protein inclusion in the diet for broiler: Enhancement of growth performance, lipid metabolism, and gut microbiota. Yushan Wu,Jing Wang,Ming Jia,Shixin Huang,Ying Cao,Ting Yao,Junguo Li,Yuxin Yang,Xu Gu. 2022

[11]Dosage of Dual-Protein Nutrition Differentially Impacts the Formation of Atherosclerosis in ApoE−/− Mice. Yingchun Huang,Kun Zhang,Li Zhang,Juhui Qiu,Lin Fu,Tieying Yin,Jing Wang,Rui Qin,Jingjie Zhang,Xianwen Dong,Guixue Wang. 2022

[12]Depletion of Gut Microbiota Inhibits Hepatic Lipid Accumulation in High-Fat Diet-Fed Mice. Han, Hui,Wang, Mengyu,Zhong, Ruqing,Yi, Bao,Schroyen, Martine,Zhang, Hongfu. 2022

[13]Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats. Yong Wang,Wentao Qi,Xiaoxuan Guo,Ge Song,Shaojie Pang,Wei Fang,Zhenzhen Peng. 2022

[14]Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish. Yajie Zhao,Qiang Hao,Qingshuang Zhang,Yalin Yang,Chao Ran,Qiyou Xu,Chenglong Wu,Wenshu Liu,Siming Li,Zhen Zhang,Zhigang Zhou. 2022

[15]Addition of solid-state fermentation product of yeast ameliorated the effects of high-fat diet on hepatic lipid metabolism, epidermal mucus, intestine and liver health, and gut microbiota of zebrafish. Jie Li,Dongmei Xia,Xiufang Jing,Yajie Zhao,Qiang Hao,Qingshuang Zhang,Mingxu Xie,Yalin Yang,Chao Ran,Qiyou Xu,Chenglong Wu,Zhen Zhang,Zhigang Zhou. 2023

[16]Effect of dietary supplementation with sanguinarine on meat quality and lipid metabolism of broilers. Yue Su,Peng Huang,Zhiyong Wu,Wanwan Dai,Yan Zhang,Jianguo Zeng. 2024

[17]Growth performance, lipid metabolism, and systemic immunity of weaned piglets were altered by buckwheat protein through the modulation of gut microbiota. Weilong Tu,Wansen Nie,Xiaohui Yao,Junjie Zhang,Hailong Zhang,Di Di,Zongjie Li. 2024

[18]Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis. Li D.,Cai H.,Liu G.,Han Y.,Qiu K.,Liu W.,Meng K.,Yang P.. 2024

[19]Propolis Modulates the Gut Microbiota-Gut Hormone-Liver AMPK Axis to Ameliorate High-Fat Diet-Induced Metabolic Disorders in Rats. Sun, Yanru,Huang, Wanwan,Shang, Yingying,El-Din, Mohamed G. Sharaf,Hang, Hua,Wang, Peng,Zhang, Cuiping,Huang, Yuan,Wang, Kai. 2025

[20]Dietary glycyrrhizin enhances reproductive performance by improving intestinal microbiota, liver lipid metabolism and ovarian senescence in aged breeder hens. Zhenwu Huang,Huchuan Liu,Guangju Wang,Huan Ge,Yanru Shi,Jinghai Feng,Chunmei Li,Minhong Zhang. 2025

作者其他论文 更多>>