数字农科院2.0

Antioxidant And Anti-Inflammatory Activities Of Safflower (Carthamus Tinctorius L.) Honey Extract

文献类型： 外文期刊

作者： Sun, LP; Shi, FF; Zhang, WW; Zhang, ZH; Wang, K

关键词： Safflower (Carthamus Tinctorius L.) Honey; Chemical Analysis; Anti-Inflammatory; Antioxidant; Nf-Kappa B; Nrf-2

期刊名称： FOODS

ISSN： 2304-8158

年卷期： 2020 年 9 卷 8 期

页码：

收录情况： JCR（2021版）

摘要： Safflower honey is a unique type of monofloral honey collected from the nectar ofCarthamus tinctoriusL. in theApis melliferacolonies of northwestern China. Scant information is available regarding its chemical composition and biological activities. Here, for the first time, we investigated this honey's chemical composition and evaluated its in vitro antioxidant and anti-inflammatory activities. Basic physicochemical parameters of the safflower honey samples in comparison to established quality standards suggested that safflower honeys presented a good level of quality. The in vitro antioxidant tests showed that extract fromCarthamus tinctoriusL. honey (ECH) effectively scavenged DPPH and ABTS(+)free radicals. In lipopolysaccharides (LPS) activated murine macrophages inflammatory model, ECH treatment to the cells inhibited the release of nitric oxide and down-regulated the expressions of inflammatory-relating genes (iNOS, IL-1 beta, TNF-alpha and MCP-1). The expressions of the antioxidant genes TXNRD, HO-1, and NQO-1, were significantly boosted in a concentration-dependent manner. ECH decreased the phosphorylation of I kappa B alpha and inhibited the nuclear entry of the NF-kappa B-p65 protein, in LPS-stimulated Raw 264.7 cells, accompany with the increased expressions of Nrf-2 and HO-1, suggesting that ECH achieved the anti-inflammatory effects by inhibiting NF-kappa B signal transduction and boosting the antioxidant system via activating Nrf-2/HO-1 signaling. These results, taken together, indicated that safflower honey has great potential into developing as a high-quality agriproduct.

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