数字农科院2.0

Low-dose cadmium enhances coronavirus infectivity by amplifying viral receptor and suppressing goblet cell differentiation

文献类型： 外文期刊

作者： Yanan Cao;Liangxing Xia;Yanjie Huang;Xueli Zhang;Chunxiao Mou;Zhenhai Chen;Rong Zhou;Shuai Zhang;Wenbin Bao

作者机构：

关键词： Cadmium;Coronavirus;Intestinal mucosal barrier;Notch signalling pathway;Susceptibility

期刊名称： Journal of Hazardous Materials

ISSN： 1873-3336

年卷期： 2025 年 499 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Emerging coronaviruses pose an escalating threat to human and animal health. Cadmium (Cd), a ubiquitous environmental toxic metal, accumulates in organisms due to its slow elimination rate. Despite its widespread presence, the impact of this non-infectious environmental factor on coronavirus pathogenicity remains poorly understood. Using porcine deltacoronavirus (PDCoV) as a model, we investigated the role of Cd in coronavirus infection, finding it exacerbates PDCoV infection in vivo, ex vivo, and in vitro. Mechanistically, Cd accumulation in intestinal epithelial cells enhances viral adhesion and invasion by damaging microvilli, disrupting tight junctions, and upregulating the aminopeptidase N (APN) expression, a key entry factor for PDCoV. Additionally, Cd suppresses intestinal stem cell differentiation into goblet cells by activating the Notch signalling pathway, exacerbating PDCoV-induced intestinal mucosal barrier dysfunction and promoting PDCoV infection. Collectively, our findings demonstrate that Cd potentiates coronavirus infectivity through a dual mechanism: upregulating viral receptor expression and disrupting intestinal mucosal integrity. This study provides mechanistic insights into how Cd exacerbates viral infection severity and informs public health strategies to mitigate coronavirus-associated morbidity and mortality.

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