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Multiple stresses induced by chronic exposure to flupyradifurone affect honey bee physiological states

文献类型： 外文期刊

作者： Jin Chen;Yong Jun Liu;Qiang Wang;Li Zhang;Sa Yang;Wang Jiang Feng;Min Shi;Jing Gao;Ping Li Dai;Yan Yan Wu

作者机构：

关键词： Apoptosis;Detoxification;Flupyradifurone;Immunity;Olfactory behavior;Oxidative stress

期刊名称： Science of the Total Environment

ISSN： 0048-9697

年卷期： 2024 年 935 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： Flupyradifurone (FPF) has been reported to have a potential risk to terrestrial and aquatic ecosystems. In the present study, the effects of chronic FPF exposure on bees were systematically investigated at the individual behavioral, tissue, cell, enzyme activity, and the gene expression levels. Chronic exposure (14 d) to FPF led to reduced survival (12 mg/L), body weight gain (4 and 12 mg/L), and food utilization efficiency (4 and 12 mg/L). Additionally, FPF exposure (12 mg/L) impaired sucrose sensitivity and memory of bees. Morphological analysis revealed significant cellular and subcellular changes in brain neurons and midgut epithelial cells, including mitochondrial damage, nuclear disintegration, and apoptosis. FPF exposure (4 and 12 mg/L) led to oxidative stress, as evidenced by increased lipid peroxidation and alterations in antioxidant enzyme activity. Notably, gene expression analysis indicated significant dysregulation of apoptosis, immune, detoxification, sucrose responsiveness and memory-related genes, suggesting the involvement of different pathways in FPF-induced toxicity. The multiple stresses and potential mechanisms described here provide a basis for determining the intrinsic toxicity of FPF.

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