数字农科院2.0

Identification and verification of the role of key metabolites and metabolic pathways on ASFV replication

文献类型: 外文期刊

作者: Zunji Shi;Xing Yang;Xijuan Shi;Dajun Zhang;Dengshuai Zhao;Yu Hao;Jinke Yang;Xintian Bie;Wenqian Yan;Guohui Chen;Lingling Chen;Xiangtao Liu;Haixue Zheng;Keshan Zhang

作者机构:

关键词: Metabolomics;Porcine medicine;Virology

期刊名称: iScience

ISSN: 2589-0042

年卷期: 2024 年 27 卷 4 期

页码:

收录情况: SCIE(2024版)

摘要: African swine fever virus (ASFV) infection usually causes viremia within a few days. However, the metabolic changes in pig serum after ASFV infection remain unclear. In this study, serum samples collected from ASFV-infected pigs at different times were analyzed using pseudotargeted metabolomics method. Metabolomic analysis revealed the dopaminergic synapse pathway has the highest rich factor in both ASFV5 and ASFV10 groups. By disrupting the dopamine synaptic pathway, dopamine receptor antagonists inhibited ASFV replication and L-dopa promoted ASFV replication. In addition, guanosine, one of the top20 changed metabolites in both ASFV5 and ASFV10 groups suppressed the replication of ASFV. Taken together, this study revealed the changed serum metabolite profiles of ASFV-infected pigs at various times after infection and verified the effect of the changed metabolites and metabolic pathways on ASFV replication. These findings may contribute to understanding the pathogenic mechanisms of ASFV and the development of target drugs to control ASF.

分类号:

  • 相关文献

[1]Pathogenicity and Distribution of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus in Pigs. Hu, S. P.,Zhang, Z.,Liu, Y. G.,Tian, Z. J.,Wu, D. L.,Cai, X. H.,He, X. J.. 2013

[2]Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells. Xianjin Kan,Yuncong Yin,Cuiping Song,Lei Tan,Xusheng Qiu,Ying Liao,Weiwei Liu,Songshu Meng,Yingjie Sun,Chan Ding. 2021

[3]Porcine Deltacoronavirus Enters Cells Via T.wo Pathways: A Protease-Mediated O ne At The Cell Surface And Another Facilitated By Cathepsins In The Endosome. Zhang, JL, Chen, JF, Shi, D, Shi, HY, Zhang, X, Liu, JB, Cao, LY, Zhu, XD, Liu, Y, Wang, XB, Ji, ZY, Feng, L. 2019

[4]On-site detection and differentiation of African swine fever virus variants using an orthogonal CRISPR-Cas12b/Cas13a-based assay. Zhe Wang,Yu Wang,Ying Zhang,Guosong Qin,Wenbo Sun,Aiping Wang,Yanfang Wang,Gaiping Zhang,Jianguo Zhao. 2024

[5]Newcastle disease virus infection remodels plasma phospholipid metabolism in chickens. Jun Dai,Xusheng Qiu,Xinyuan Cui,Yiyi Feng,Yuechi Hou,Yingjie Sun,Ying Liao,Lei Tan,Cuiping Song,Weiwei Liu,Yongyi Shen,Chan Ding. 2024

[6]Comparative Effect Of Black, Green, O.olong, And White Tea I ntake On Weight Gain And Bile Acid Metabolism. Xu, Hairong,Gaikwad, Nilesh W.,Ye, Jianhui,Sun, Lili. 2019

[7]Metabolic responses and "omics" technologies for elucidating the effects of heat stress in dairy cows. Min, Li,Zhao, Shengguo,Tian, He,Zhou, Xu,Zhang, Yangdong,Li, Songli,Zheng, Nan,Wang, Jiaqi,Min, Li,Yang, Hongjian.

[8]Metabolic map of mature maize kernels. Rao, Jun,Cheng, Fang,Hu, Chaoyang,Quan, Sheng,Lin, Hong,Wang, Jing,Chen, Guihua,Zhang, Dabing,Shi, Jianxin,Zhao, Xiangxiang,Alexander, Danny,Guo, Lining,Wang, Guoying,Lai, Jinsheng,Shi, Jianxin.

[9]Identification of diagnostic biomarkers and metabolic pathway shifts of heat-stressed lactating dairy cows. Tian, He,Zheng, Nan,Li, Songli,Zhang, Yangdong,Wang, Jiaqi,Wang, Weiyu,Cheng, Jianbo.

[10]Metabolomic biomarkers identify differences in milk produced by Holstein cows and other minor dairy animals. Yang, Yongxin,Zheng, Nan,Zhao, Xiaowei,Zhang, Yangdong,Han, Rongwei,Yang, Jinhui,Zhao, Shengguo,Li, Songli,Guo, Tongjun,Zang, Changjiang,Wang, Jiaqi,Yang, Yongxin,Zhao, Xiaowei.

[11]Sterol content in the artificial diet of Mythimna separata affects the metabolomics of Arma chinensis (Fallou) as determined by proton nuclear magnetic resonance spectroscopy. Liu, Chen-xi,Zhang, Li-sheng,Wang, Meng-qing,Chen, Hong-yin,Guo, Yi,Liu, Chen-xi,Zhang, Li-sheng,Wang, Meng-qing,Chen, Hong-yin.

[12]Complex molecular mechanisms underlying seedling salt tolerance in rice revealed by comparative transcriptome and metabolomic profiling. Wang, Wen-Sheng,Zhao, Xiu-Qin,Li, Min,Huang, Li-Yu,Xu, Jian-Long,Zhang, Fan,Cui, Yan-Ru,Fu, Bin-Ying,Li, Zhi-Kang,Li, Min,Xu, Jian-Long,Fu, Bin-Ying,Li, Zhi-Kang.

[13]Recent advancements in detecting sugar-based adulterants in honey - A challenge. Wu, Liming,Du, Bing,Chen, Lanzhen,Zhao, Liuwei,Wang, Miao,Xue, Xiaofeng,Wu, Liming,Chen, Lanzhen,Wang, Miao,Xue, Xiaofeng,Wu, Liming,Chen, Lanzhen,Wang, Miao,Xue, Xiaofeng,Vander Heyden, Yvan.

[14]Shifts in metabolomic profiles of the parasitoid Nasonia vitripennis associated with elevated cold tolerance induced by the parasitoid's diapause, host diapause and host diet augmented with proline. Li, Yuyan,Zhang, Lisheng,Chen, Hongyin,Li, Yuyan,Denlinger, David L.,Li, Yuyan,Denlinger, David L.,Kostal, Vladimir,Simek, Petr,Moos, Martin.

[15]Metabolomics analysis reveals large effect of roughage types on rumen microbial metabolic profile in dairy cows. Zhao, S.,Dong, Z.,Zhao, S.,Zhao, J.,Bu, D.,Sun, P.,Wang, J.,Zhao, J..

[16]Effect of the DGAT1 K232A genotype of dairy cows on the milk metabolome and proteome. Lu, Jing,van Hooijdonk, Toon,Hettinga, Kasper,Lu, Jing,Boeren, Sjef,Vervoort, Jacques,Lu, Jing.

[17]Soybean Omics and Biotechnology in China. Guo, Yong,Wang, Xiao-Bo,He, Wei,Zhou, Guo-An,Guo, Bing-Fu,Zhang, Le,Liu, Zhang-Xiong,Luo, Zhong-Qin,Wang, Li-Hui,Qiu, Li-Juan. 2011

[18]Nontargeted Analysis Using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry Uncovers the Effects of Harvest Season on the Metabolites and Taste Quality of Tea (Camellia sinensis L.). Dai, Weidong,Qi, Dandan,Yang, Ting,Lv, Haipeng,Guo, Li,Zhang, Yue,Zhu, Yin,Peng, Qunhua,Xie, Dongchao,Tan, Junfeng,Lin, Zhi.

[19]Nonylphenol Toxicity Evaluation and Discovery of Biomarkers in Rat Urine by a Metabolomics Strategy through HPLC-QTOF-MS. Zhang, Yan-Xin,Yang, Xin,Zou, Pan,Du, Peng-Fei,Wang, Jing,Jin, Fen,Jin, Mao-Jun,She, Yong-Xin,Du, Peng-Fei,Wang, Jing,Jin, Fen,Jin, Mao-Jun,She, Yong-Xin. 2016

[20]Nontargeted Modification-Specific Metabolomics Investigation of Glycosylated Secondary Metabolites in Tea (Camellia sinensis L.) Based on Liquid Chromatography-High-Resolution Mass Spectrometry. Dai, Weidong,Tan, Junfeng,Xie, Dongchao,Li, Pengliang,Lv, Haipeng,Zhu, Yin,Guo, Li,Zhang, Yue,Peng, Qunhua,Lin, Zhi,Lu, Meiling.

作者其他论文 更多>>