数字农科院2.0

Surface engineering of carbon dots for highly sensitive α-glucosidase assay and inhibition evaluation

文献类型： 外文期刊

作者： Meijuan Liang;Gege Song;Yeqing Wan;Yingying Chen;Fuan Wang;Xiaoqing Liu

作者机构：

关键词： Carbon dots;Fluorescent sensor;Inhibitor;α-Glucosidase;β-Cyclodextrin

期刊名称： Chinese Chemical Letters

ISSN： 1001-8417

年卷期： 2024 年 35 卷 3 期

页码：

收录情况： SCIE（2024版） ; ; CSCD（2023-2024年度） ; ; 科技核心（2024版）

摘要： Monitoring α-glucosidase (α-Glu) activity is of great significance for the early diagnosis of type II diabetes. Here the blue fluorescent carbon dots (CDs) were integrated with two different recognizing molecules, β-cyclodextrin and phenylboronic acid, for assembling a multifunctional CDs (mCDs) nanoplatform for sensitively analyzing α-Glu and its inhibitors. The hydrolyzed product of 4-nitrophenyl-α-D-glucopyranoside (α-Glu substrate), p-nitrophenol, could efficiently quench the fluorescence of mCDs due to its cooperative molecular recognition with β-cyclodextrin and phenylboronic acid. The mCDs could be utilized for the detection of α-Glu activity with the limit of detection of 0.030 U/L. Moreover, the present α-Glu detection platform revealed a high selectivity, and other natural enzymes showed scarcely any effect on the present mCDs system. The proposed method could be facilely used to screen α-Glu inhibitors with satisfying performance. The rational mCDs is expected to supplement more comprehensive biosensing platforms for highly sensitive and specific recognition of disease-relevant biomarkers with clinical importance.

分类号：

  • 相关文献

[1]Ratiometric Fluorescent Sensor for Hg2+ and Thiophanate-Methyl Based on Nitrogen-Doped Carbon Dots and Rhodamine B. Zhang, Changsheng,Liang, Shuang,Liu, Haijun,Hu, Yuxuan,Zhang, Xinzhong,Luo, Fengjian,Lou, Zhengyun,Zhou, Li,Yang, Mei. 2025

[2]Determination of potential α-glucosidase inhibitors in Jinxuan black tea based on bioaffinity ultrafiltration combined with UHPLC-Q-Exactive-MS. Guangneng Li,Jianyong Zhang,Hongchun Cui,Ying Gao,Yuliang Deng,Debao Niu,Junfeng Yin. 2025

[3]Graphene oxide-based fluorescent sensor for sensitive turn-on detection of sinapine. Xiang, Xia,Han, Ling,Zhang, Zhen,Huang, Fenghong.

[4]Formation and stabilization mechanism of β-cyclodextrin inclusion complex with C10 aroma molecules. Changyue Deng,Chuan Cao,Yingying Zhang,Jingwei Hu,Yongqiang Gong,Mingming Zheng,Yibin Zhou. 2022

[5]Stabilization of capsanthin in physically-connected hydrogels: Rheology property, self-recovering performance and syringe/screw-3D printing. Hongxia Wang,Chaoyang Wu,Juncheng Zhu,Yang Cheng,Yuxin Yang,Shihao Qiao,Bo Jiao,Liang Ma,Yu Fu,Hai Chen,Hongjie Dai,Yuhao Zhang. 2023

[6]Inclusion Complexes of Ethanamizuril with β- and Hydroxypropyl-β-Cyclodextrin in Aqueous Solution and in Solid State: A Comparison Study. Juan Guo,Lifang Zhang,Mi Wang,Yingchun Liu,Chenzhong Fei. 2024

[7]The soybean lecithin-cyclodextrin-vitamin E complex nanoparticles stabilized Pickering emulsions for the delivery of β-carotene: Physicochemical properties and in vitro digestion. Lei Hao,Junjiao Li,Jin Mao,Qi Zhou,Qianchun Deng,Zhaofei Chai,Lei Zheng,Jie Shi. 2024

[8]Cyclodextrin-Based Pickering Emulsion Significantly Increases 6-Gingerol Loading Through Two Different Mechanisms: Cyclodextrin Cavity and Pickering Core. Xingran Kou,Dongdong Su,Jingzhi Zhang,Fei Pan,Jiamin Zhu,Qingran Meng,Qinfei Ke. 2025

[9]Regulated the aggregation of bile salts by β-Cyclodextrin and Tangeretin at the oil-water interface for inhibiting lipid digestion. Xingran Kou,Wenhui Li,Fei Pan,Xin Huang,Qingran Meng,Yunchong Zhang,Qinfei Ke. 2024

[10]Suppression of Bta11975, an α-glucosidase, by RNA interference reduces transmission of tomato chlorosis virus by Bemisia tabaci. Ding Yi Hui Lu,Hao Yue,Li Ping Huang,De Yong Zhang,Zhan Hong Zhang,Zhuo Zhang,Youjun Zhang,Fan Li,Fei Yan,Xu Guo Zhou,Xiao Bin Shi,Yong Liu. 2021

[11]Physicochemical, rheological properties and in vitro hypoglycemic activities of polysaccharide fractions from peach gum. Jiaxin Chen,Mo Zhou,Meng Liu,Jinfeng Bi. 2022

[12]Chemical profile of phenolic extracts from rapeseed meal and inhibitory effects on α-glucosidase: UPLC-MS/MS analysis, multispectral approaches, molecular simulation and ADMET analysis. Huihui Liu,Ziliang Li,Xiaoyang Xia,Ruiying Zhang,Wen Wang,Xia Xiang. 2023

[13]Exploring formation of turanose in honey via stable isotope labelling and high-resolution mass spectrometry analysis. Yuzhe Yuan,Sha Yan,Liming Wu,Haitao Xu,Guodong Mu,Xiaofeng Xue. 2024

[14]Extraction effects of eight deep eutectic solvents on dianhong black tea: From chemical composition analysis to antioxidant and α-glucosidase inhibitory assessments. Zixin Zhao,Mingchun Wen,Zongde Jiang,Shengxiao Su,Yong Quan Xu,Zisheng Han,Yong Cheng,Mengting Zhu,Liang Zhang. 2024

[15]Polyphenols from Flos Trollii inhibit α-amylase and α-glucosidase: Kinetic analysis and mechanistic insights. Xiaoai Zhu,Kebing Yan,Xianqing Ye,Xia Xiang,Yuan Ru,Yiying Niu,Yage Liu,Jun Xi,Kunlun Liu. 2025

[16]Synthesis Of Carbon Dots From P.ear Juice For Fluorescence D etection Of Cu2+ Ion In Water. Liu, LL, Gong, HR, Li, DF, Zhao, LN. 2018

[17]BSA-carbon dots a promising off-on fluorescence probe for detecting glyphosate residues in agricultural products. Wang, Qian,Wang, Miao,Zheng, Lufei,She, Yongxin,Wang, Jing,Jia, Minghong,Abd El-Aty, A. M.. 2023

[18]Engineered exosomes-based photothermal therapy with mri/ct imaging guidance enhances anticancer efficacy through deep tumor nucleus penetration. Min Yang,Xiaohui Wang,Fang Pu,Ying Liu,Jia Guo,Shuzhuo Chang,Guoying Sun,Yinghua Peng. 2021

[19]A novel fluorescent probe for Fe3+ detection based on two-dimensional leaf-like structure CDs@ZIF-L. Gao M.,Liu G.,Tan Q.,Zhao C.,Chen G.,Zhai R.,Hua Y.,Huang X.,Wang J.,Xu D.. 2022

[20]Pyridinic Nitrogen Doped Carbon Dots Supply Electrons to Improve Photosynthesis and Extracellular Electron Transfer of Chlorella pyrenoidosa. Huang, Xiaoman,Lin, Junjie,Liang, Jiarong,Kou, Erfeng,Cai, Wenxiao,Zheng, Yinjian,Zhang, Haoran,Zhang, Xuejie,Liu, Yingliang,Li, Wei,Lei, Bingfu. 2023

作者其他论文 更多>>