数字农科院2.0

Dendritic cell-based biomimetic nanoparticles for foot-and-mouth disease induce robust cellular immunity

文献类型： 外文期刊

作者： Zhan Gao;Xiaoqing Liu;Yao Lei;Junjun Shao;Guanglei Zhang;Zhuo Hou;Guangqing Zhou;Jin'en Wu;Huichen Guo;Huiyun Chang;Wei Liu

作者机构：

关键词： Biomimetic nanoparticles;FMD vaccine;Foot-and-mouth disease;Lymph node targeting

期刊名称： Antiviral Research

ISSN： 0166-3542

年卷期： 2024 年 231 卷

页码：

收录情况： SCIE（2024版）

摘要： Foot-and-mouth disease (FMD) is a highly contagious and economically devastating viral disease of ruminants and swine, badly affecting the livestock industry worldwide. In clinical practice, vaccination is a frequently employed strategy to prevent foot-and-mouth disease (FMDV). However, commercial inactivated vaccines for FMD mainly rely on humoral immunity, exhibiting poor cellular immune responses and causing adverse reactions. Here, we use the double emulsion method to prepare poly (lactic-co-glycolic acid) nanoparticles (PLGA-NP) encapsulated with IL-2 cytokines, wrap the dendritic cell (DC) membrane carrying FMDV antigen information on the surface of the nanoparticles, obtaining a biomimetic nanoparticle vaccine Biom@DC with uniform size. This vaccine can effortlessly move through lymph nodes due to its nanoscale size advantage. It also possesses DC ability to present antigens, and antigen presentation can be made more effective with high biocompatibility. The sustained release of IL-2 encapsulated in the core of PLGA-NP in vivo can effectively promote the body's cellular immune response. Immune tests on mice have shown that Biom@DC may greatly increase T cell activation and proliferation both in vivo and in vitro, while also significantly reducing the fraction of inhibitory Treg cells. Furthermore, in the micro serum neutralization assay for FMDV, it has been demonstrated that the group vaccinated with Biom@DC exhibits a clear neutralizing effect. Given its strong immunogenicity, Biom@DC has the potential to develop into a novel, potent anti-FMDV vaccination.

分类号：

  • 相关文献

[1]Foot and mouth disease vaccine efficacy in Africa: a systematic review and meta-analysis. Ashenafi Kiros Wubshet,Gebremeskel Mamu Werid,Teshale Teklue,Luoyi Zhou,Chimedtseren Bayasgalan,Ariunaa Tserendorj,Jinjin Liu,Livio Heath,Yuefeng Sun,Yaozhong Ding,Wenxiu Wang,Alexei D. Zaberezhny,Yongsheng Liu,Jie Zhang. 2024

[2]Establishment of a Murine alpha nu beta 1 Transgenic CHO-K1 Cell Line and its Susceptibility to Foot-and-Mouth Disease Virus Type Asia 1/HN/2006 in China. Zhang, Y.,Zheng, H. X.,Zhang, Z. D.,Jin, Y.,Yang, F.,He, J. J.,Cao, W. J.,Sun, D. H.,Lv, L.. 2013

[3]Recombinant Bivalent Vaccine against Foot-and-Mouth Disease Virus Serotype O/A Infection in Guinea Pig. Yi, JZ,Liu, MQ,Zhu, CZ,Zhang, Q,Sheng, ZT,Du, QY,Yan, WY,Zheng, ZX.

[4]Genetic characterization of a new pandemic Southeast Asia topotype strain of serotype O foot-and-mouth disease virus isolated in China during 2010. Zheng, Haixue,He, Jijun,Guo, Jianhong,Jin, Ye,Yang, Fan,Lv, Lv,Liu, Xiangtao. 2012

[5]Synthesis of empty capsid-like particles of Asia I foot-and-mouth disease virus in insect cells and their immunogenicity in guinea pigs. Cao, Yimei,Lu, Zengjun,Sun, Jiachuan,Bai, Xingwen,Sun, Pu,Bao, Huifang,Chen, Yingli,Guo, Jianhong,Li, Dong,Liu, Xiangtao,Liu, Zaixin.

[6]An overview of control strategy and diagnostic technology for foot-and-mouth disease in China. Ding, Yao-Zhong,Chen, Hao-Tai,Zhang, Jie,Zhou, Jian-Hua,Ma, Li-Na,Zhang, Liang,Gu, Yuanxin,Liu, Yong-Sheng. 2013

[7]A reverse transcription loop-mediated isothermal amplification assay to rapidly diagnose foot-and-mouth disease virus C. Ding, Yao-zhong,Zhou, Jian-hua,Ma, Li-na,Qi, Yan-ni,Zhang, Jie,Zhang, Yong-guang,Ding, Yao-zhong,Zhang, Jie,Zhang, Yong-guang,Wei, Gang.

[8]Rapid typing of foot-and-mouth disease serotype Asia 1 by reverse transcription loop-mediated isothermal amplification. Liu, Yong-sheng,Liu, Xiang-tao. 2011

[9]Induction of Partial Protection against Foot and Mouth Disease Virus in Guinea Pigs by Neutralization with the Integrin beta 6-1 Subunit. Zhang, Yan,Sun, Yingjun,Yang, Fan,Guo, Jianhong,He, Jijun,Wu, Qiong,Cao, Weijun,Lv, Lv,Zheng, Haixue,Zhang, Zhidong. 2013

[10]Hollow Mesoporous Silica Nanoparticles As D.elivery Vehicle Of Foot-And-Mouth D isease Virus-Like Particles Induce Persistent Immune Responses In Guinea Pigs. Bai, MY,Dong, H,Su, X,Jin, Y,Sun, SQ,Zhang, YP,Yang, YS,Guo, HC. 2019

[11]Development And Validation Of A C.ompetitive Elisa Based On B acterium-Original Virus-Like Particles Of Serotype O Foot-And-Mouth Disease Virus For Detecting Serum Antibodies. Ran, XH, Yang, ZY, Bai, MY, Zhang, Y, Wen, XB, Guo, HC, Sun, SQ. 2019

[12]Promotion Of Cellular And Humoral Immunity Against Foot-And-Mouth Disease Virus By Immunization With Virus-Like Particles Encapsulated In Monophosphoryl Lipid A And Liposomes. Kim, WS, Zhi, Y, Guo, HC, Byun, EB, Lim, JH, Seo, HS. 2020

[13]Article four simple biomimetic mineralization methods to improve the thermostability and immunogenicity of virus-like particles as a vaccine against foot-and-mouth disease. Mengnan Guo,Jiajun Li,Zhidong Teng,Mei Ren,Hu Dong,Yun Zhang,Jiaxi Ru,Ping Du,Shiqi Sun,Huichen Guo. 2021

[14]Selection of vaccine candidate for foot-and-mouth disease virus serotype o using a blocking enzyme-linked immunosorbent assay. Cao Yimei,Li Kun,Xing Xiangchuan,Bao Huifang,Huang Nana,Zhu Guoqiang,Bai Xingwen,Sun Pu,Fu Yuanfang,Li Pinghua,Zhang Jing,Ma Xueqing,Li Dong,Liu Zaixin,Lu Zengjun. 2021

[15]Development of a competitive ELISA method based on VLPs detecting the antibodies of serotype A FMDV. Yun Zhang,Rui Wang,Manyuan Bai,Xuefei Wang,Hu Dong,Jiajun Li,Suyu Mu,Haisheng Miao,Jianling Song,Shiqi Sun,Huichen Guo. 2022

[16]Self-Assembling Nanovaccine Fused with Flagellin Enhances Protective Effect against Foot-and-Mouth Disease Virus. Pei, Chenchen,Dong, Hu,Teng, Zhidong,Wei, Sumin,Zhang, Yun,Yin, Shuanghui,Tang, Jianli,Sun, Shiqi,Guo, Huichen. 2023

[17]Fluorescent Immunochromatographic Assay For Quantitative Detection Of The Foot-And-Mouth Disease Virus Serotype O Antibody. Hou, FP, Bai, MY, Zhang, Y, Liu, HY, Sun, SQ, Guo, HC. 2020

[18]Salmonella Vaccine Vector System For Foot-And-Mouth Disease Virus And Evaluation Of Its Efficacy With Virus-Like Particles. Zhi, Y, Ji, HJ, Guo, HC, Lim, JH, Byun, EB, Kim, WS, Seo, HS. 2021

[19]Construction of an Effective Delivery System for DNA Vaccines Using Biodegradable Polylactic Acid Based Microspheres. Ren, Shuaikai,Guo, Liang,Wang, Chunxin,Ru, Jiaxi,Yang, Yunqi,Wang, Yan,Sun, Changjiao,Cui, Haixin,Zhao, Xiang,Guo, Huichen. 2021

[20]Novel capsid-specific single-domain antibodies with broad foot-and-mouth disease strain recognition reveal differences in antigenicity of virions, empty capsids, and virus-like particles. Haozhou Li,Aldo Dekker,Shiqi Sun,Alison Burman,Jeroen Kortekaas,Michiel M. Harmsen. 2021

作者其他论文 更多>>