数字农科院2.0

Synergistic mosquito control via integration of spider peptide neurotoxin and Pyrethroid insecticide

文献类型： 外文期刊

作者： 张慧慧;云颖;谭瑶;杨宇航;何天顺;张佳琪;时楚婷;胡天野;汪侃;刘泽文

关键词： Mosquito; Spider neurotoxin; Nano-formulation

期刊名称： International Journal of Biological Macromolecules

ISSN： 0141-8130

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Mosquitoes are important vectors of human diseases, with Anopheles sinensis posing substantial health risks across Asia. Although pyrethroids remain widely deployed, their effectiveness is compromised by resistance associated with sodium channel mutations. Spider peptide neurotoxins are potential biopesticides. Here, we evaluated the insecticidal efficacy of the Pardosa pseudoannulata neurotoxin PPTX-04, both alone and in combination with pyrethroids, against A. sinensis. Bioassays were conducted on laboratory and field populations, and functional analyses were performed on wild-type and mutant sodium channels (AsNav1–1). The co-toxicity of PPTX-04 with etofenprox was assessed across different mixture ratios. To enhance applicability, a nano-formulated version (Nano-PPTX-04) was developed and tested. PPTX-04 displayed potent activity against A. sinensis and retained efficacy against the L1014 sodium channel mutation that significantly reduced pyrethroid susceptibility. Mixtures of PPTX-04 and etofenprox produced synergistic toxicity at specific ratios (e.g., 3:1, 2:1). Notably, Nano-PPTX-04 exhibited superior potency relative to the native peptide, and its combinations with etofenprox yielded pronounced synergistic effects, particularly in pyrethroid-resistant field populations. Collectively, our laboratory-scale findings highlight the potential of PPTX-04, especially in nano-formulated form and in synergy with pyrethroids, as a potential strategy for mosquito control. This approach warrants further investigation as a viable solution to pyrethroid resistance.

分类号：

  • 相关文献

[1]Dibenzo-alpha-pyrones: a new class of larvicidal metabolites against Aedes aegypti from the endophytic fungus Hyalodendriella sp Ponipodef12. Mao, Ziling,Lai, Daowan,Liu, Xunda,Fu, Xiaoxiang,Meng, Jiajia,Wang, Ali,Wang, Xiaohan,Sun, Weibo,Zhou, Ligang,Liu, Zhi Long,Liu, Yang.

[2]A Viral Metagenomic Analysis Reveals R.ich Viral Abundance And D iversity In Mosquitoes From Pig Farms. Hameed, M, Liu, K, Anwar, MN, Wahaab, A, Li, CX, Di, D, Wang, X, Khan, S, Xu, JP, Li, BB, Nawaz, M, Shao, DH, Qiu, YF, Wei, JC, Ma, ZY. 2019

[3]The transcriptional response in mosquitoes distinguishes between fungi and bacteria but not Gram types. Hixson B.,Huot L.,Morejon B.,Yang X.,Nagy P.,Michel K.,Buchon N.. 2024

[4]Short Communication: Mosquito Histone 2A Protein Facilitate Japanese Encephalitis Virus Infection in the Mosquito. Muddassar, Hameed,Chen, Mengli,Zhang, Tong,Mohsin, Nawaz,Kang, Lei,Zheng, Jiayang,Li, Zongjie,Shao, Donghua,Wei, Jianchao,Li, Beibei,Qiu, Yafeng,Ma, Zhiyong,Liu, Ke. 2024

[5]Genotype Change in Circulating JEV Strains in Fujian Province, China. Nihua Dong,Xinya Zhang,Hailong Zhang,Jiayang Zheng,Yafeng Qiu,Zongjie Li,Beibei Li,Ke Liu,Donghua Shao,Zhiyong Ma,Jianchao Wei. 2023

[6]Isolation and Characterization of Getah Virus GD2202 from Mosquitoes in Foshan, China. Deng, Ying-Ling,Lin, Zi-Yi,Lin, Rui,Lu, Zi-Shuo,Yan, Xing-Xiu,Li, Li-Xia,Lu, Hui-Jun,Bai, Xue,Jin, Ning-Yi,Liu, Hao. 2025

[7]Transfluthrin-loaded electrospun nanohybrids for long-term mosquito control and efficient air filtration. Huiping Chen,Zhifei Yang,Yingxi Zhang,Qing Yin,Qiliang Huang,Lidong Cao. 2025

[8]Larvicidal efficacy of silk sericin-capped silver nano bioinsecticides (SS-AgNBIs) against Aedes aegypti. Muniba Tariq,Hafiz Muhammad Tahir,Aamir Ali,Dilawar Abbas,Samima Asad Butt,Mostafa A. Abdel-Maksoud,Fahd A. Al-Mekhlafi. 2025

作者其他论文 更多>>