数字农科院2.0

Framework nucleic acids as powerful mediator for metal nanomaterials in biosensing: A review

文献类型： 外文期刊

作者： Rongqi Zhai;Ge Chen;A. M. Abd El-Aty;Guangyang Liu;Beibei Liu;Linglong Chen;Xiaomin Xu;Yanguo Zhang;Jun Lv;Jing Wang;Maojun Jin;Donghui Xu

作者机构：

关键词： Assembly;Framework nucleic acids;Mediator, modulation;Metal nanomaterials

期刊名称： International Journal of Biological Macromolecules

ISSN： 0141-8130

年卷期： 2025 年 328 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Metal nanomaterials are widely used in detection, diagnosis and medical imaging because of their high catalytic activity, easy preparation, excellent optical properties and high stability. However, their pseudo monodisperse nanostructures and spatially disordered distribution hinder their optical properties. In recent years, framework nucleic acids (FNAs) have been used as ligands (templates or molds) to mediate the synthesis of many metal nanomaterials, such as gold nanoparticles, silver nanoparticles, and gold‑palladium nanoparticles, for modulating and assembling the distribution of metal nanomaterials. Framework nucleic acids possess monodispersity, natural biocompatibility, addressability, spatial conformability and programmability. Thus, framework nucleic acids have vast potential to mediate the distribution of metal nanomaterials. Reviews on framework nucleic acid-mediated metal nanomaterials are rare. Therefore, this review aims to fill this gap by focusing on the design, synthesis, purification, and characterization of framework nucleic acids as mediating tools to facilitate readers' specific understanding of their properties, providing a comprehensive overview of framework nucleic acids to mediate the modulation and assembly of metal nanomaterials and their application in biosensors.

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