数字农科院2.0

Lumpy skin disease virus 001/156 protein is a virulence factor that suppresses interferon production through impairing IRF3 dimerization

文献类型： 外文期刊

作者： Minmin Zhang;Yujie Shi;Xinyin Lu;Qiwei Zhang;Yubo Zhao;Shaohan Li;Zhiyuan Wen;Jinying Ge;Xijun Wang;Jie Li;Zhigao Bu;Xin Yin

作者机构：

关键词： 牛结节性皮肤病病毒;;LSDV; 001/156; IRF3

期刊名称： PLOS Pathogens

ISSN： 1553-7366

年卷期： 2025 年 21 卷 7 July 期

页码：

收录情况： SCIE（2025版）

摘要： Lumpy skin disease virus (LSDV), a member of the genus Capripoxvirus within the family Poxviridae, causes significant disease in cattle and is classified as a notifiable disease by the World Organization for Animal Health (WOAH). The virus contains a double-stranded linear DNA genome of approximately 151 kbp, encoding 156 predicted open reading frames (ORFs) for various proteins. However, only a limited number of these proteins have been characterized, with the functions of many—particularly those encoded within the inverted terminal repeat (ITR) regions—remaining largely unknown. In this study, we utilized homologous recombination to generate LSDV mutants with deletions of the LSDV 001/156 gene to investigate its role. LSDV 001/156, an uncharacterized protein located within the ITR region, was identified as a late-expressed gene product incorporated into virions and involved in viral replication. Further analysis revealed that LSDV 001/156 acts as a negative regulator of the interferon (IFN) signaling pathway. It interacts with interferon regulatory factor 3 (IRF3), disrupting its dimerization and nuclear translocation, thereby attenuating IFN production. Functional studies demonstrated that the LSDV mutant lacking the 001/156 gene exhibited reduced replication and virulence in cattle compared to the wild-type virus, likely due to enhanced IFN responses in the absence of this immune-evasive protein. In summary, our findings uncover a novel role of the LSDV 001/156 gene in modulating the host intrinsic antiviral response, shedding light on the mechanisms underlying LSDV pathogenesis. This study highlights the importance of ITR-encoded genes in immune evasion and virulence, providing new insights into LSDV biology and its interactions with the host immune system.

分类号：

  • 相关文献

[1]The Nicotiana benthamiana microtubule-associated E3 ubiquitin ligase degrades a host immune regulator and a viral effector to enhance antiviral defense. 王坤,,,,傅帅,,,,谭羽翀,,,,吴良,,,,王亚琴,,,,周雪平. 2025

[2]Fine-tuning of the CRWN2-NTL9 module to repress PR1 expression by a viral effector during geminivirus infection. 苏晨露,,,,王亚琴,,,,李方方,,,,梅玉振,,,,周雪平. 2025

[3]A key heavy metal-binding protein orchestrates plant resistance against a geminivirus. 刘慧,,,,胡涛,,,,李方方,,,,王亚琴,,,,梅玉振,,,,周雪平. 2025

[4]Divergence in global plant carbon use efficiency across data-driven estimates, satellite product, and process-oriented models. Lei He,,,,Josep Peñuelas,,,,Jingfeng Xiao,,,,Xiaolu Tang,,,,Yue He,,,,Menglin Si,,,,Zhao-Liang Li. 2025

[5]Reconstruction of cloudy land surface temperature by combining surface energy balance theory and solar-cloud-satellite geometry. Wenhui Du,,,,Zhao-Liang Li,,,,Zhihao Qin,,,,Jinlong Fan,,,,Xiangyang Liu,,,,Chunliang Zhao,,,,Kun Cao. 2025

[6]Contrasting temporal dynamics of land surface temperature response to different types of forest loss. Jing Li,,,,Zhao-Liang Li,,,,Xiangyang Liu,,,,Yitao Li,,,,Meng Liu,,,,Nanshan You,,,,Hua Wu,,,,Lei He,,,,Menglin Si,,,,Ronglin Tang,,,,Chenghu Zhou,,,,Wei Zhao,,,,Si-Bo Duan,,,,Pei Leng,,,,Wenqi Liu,,,,Enyu Zhao,,,,Bo-Hui Tang,,,,Zhenong Jin. 2025

[7]Key genes and mechanisms underlying natural variation of silique length in oilseed rape (Brassica napus L.) germplasm. Quaid Hussain, Jiepeng Zhan, Huabing Liang, Xinfa Wang, Guihua Liu, Jiaqin Shi, Hanzhong Wang. 2021

[8]Engineering plants using diverse CRISPR-associated proteins and deregulation of genome-edited crops. Zaman, Qamar U.,Raza, Ali,Lozano-Juste, Jorge,Chao, Li,Jones, Michael G. K.,Wang, Hua-Feng,Varshney, Rajeev K.. 2024

[9]上部烟叶灰分及其钙、镁、硫、磷含量与烟叶品质的关系及近红外模型研究. 付秋娟,,郝贤伟,,杜咏梅,,毕一鸣,,孙婷婷. 2025

[10]Evaluation of different clean heat supply modes based on crop straws in the rural areas of Northern China. 霍丽丽,,姚宗路,,贾吉秀,,赵立欣,,丛宏斌,,孟海波,,袁艳文. 2020

[11]Development and characterization of chromosome segment substitution lines derived from Oryza rufipogon in the genetic background of O. sativa spp. indica cultivar 9311. 乔卫华,,齐兰,,程志军,,苏龙,,李静,,孙妍,,任军芳,,郑晓明,,杨庆文. 2016

[12]OsCOL16, encoding a CONSTANS-like protein, represses flowering by up-regulating Ghd7, expression in rice. 吴玮勋,,郑晓明,,陈代波,,张迎新,,马薇薇,,张欢,,孙连平,,杨峥赋,,赵春德,,詹晓德,,沈喜红,,于萍,,付亚平,,朱珊珊,,曹立永,,程式花. 2017

[13]An egg parasitoid assesses host egg quality from afar using oviposition-induced plant volatiles. Tian, Zhiqiang,Wang, Yuanyuan,Sun, Tao,Hu, Xiaoyun,Hao, Wanting,Zhao, Te,Wang, Yanan,Zhang, Lei,Jiang, Xingfu,Turlings, Ted C. J.,Li, Yunhe. 2025

[14]Regulation of plant immunity through histone H3 β-hydroxybutyrylation-mediated transcriptional control. 徐秋涛,,陈正庭,,王瑞,,,,马瑄,,,,段宇航,,,,海杜,,,,陈静,,,,程仲毅,,,,郑路,,,,黄俊斌,,,,张积森,,,,赵毓,,,,陈晓洋. 2025

[15]A glutamyl–tRNA reductase and its binding protein promote transitory starch biosynthesis and enhance grain quality and yield in rice. 段影青,李晓雪,马刘洋,焦桂爱,操瑞节,董楠楠,李欣伟,王梓航,王平,唐绍清,魏祥进,胡培松. 2025

[16]Epi-transcriptome analysis reveals the lack of N6-methyladenosine modification in two RNA viruses infecting watermelon. 潘福安,,,,荆嘉贤,,,, Yanhong Qiu,,,,Maoying Li,,,,周雪平,,,,李少芳. 2025

[17]黄曲霉毒素阻控与花生超级结瘤耦合效应研究初报. 周扬,,岳晓凤,,唐晓倩,,闫洪林,,张奇,,李培武. 2021

[18]盐碱地麦后复种绿肥与氮肥减施对小麦产量、环境 足迹及经济效益的协同效应. 张梦璇,,常芳弟,,魏禾雅,,李晓红,,伍林美,,张宏媛. 2025

[19]Mobile genetic elements affect the dissemination of antibiotic resistance genes (ARGs) of clinical importance in the environment. Ye Li ,,,,Ruilin Li ,,,,Jie Hou ,,,, Xuan Sun ,,,, Yajun Wang,,,, Linyun Li ,,,,Fengxia Yang ,,,,Yanpo Yao ,,,, Yi An. 2023

[20]Process simulation and economic and environmental evaluation of a corncob-based biorefinery system. Fang Liu, Xiang Guo, Yuan Wang, Guanyi Chen, Li'an Hou. 2021

作者其他论文 更多>>