数字农科院2.0

Isolation, Characterization, and Bioherbicidal Potential of the 16-Residue Peptaibols from Emericellopsis sp. XJ1056

文献类型： 外文期刊

作者： Kainan Song;Yutong Ai;Jianshuang Zhou;Baoqing Dun;Qun Yue;Liwen Zhang;Yuquan Xu;Chen Wang

作者机构：

关键词： Amaranthus retroflexus;bioherbicide;fungal natural products;peptaibol;weed control

期刊名称： Journal of Agricultural and Food Chemistry

ISSN： 0021-8561

年卷期： 2024 年 72 卷 12 期

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： Eco-friendly bioherbicides are urgently needed for managing the problematic weed Amaranthus retroflexus. A mass spectrometry- and bioassay-guided screening approach was employed to identify phytotoxic secondary metabolites from fungi for the development of such bioherbicides. This effort led to the discovery of six phytotoxic 16-residue peptaibols, including five new compounds (2-6) and a known congener (1), from Emericellopsis sp. XJ1056. Their planar structures were elucidated through the analysis of tandem mass and NMR spectroscopic data. The absolute configurations of the chiral amino acids were determined by advanced Marfey’s method and chiral-phase liquid chromatography-mass spectrometry (LC-MS) analysis. Bioinformatic analysis and targeted gene disruption identified the biosynthetic gene cluster for these peptaibols. Compounds 1 and 2 significantly inhibited the radicle growth of A. retroflexus seedlings, and 1 demonstrated potent postemergence herbicidal activity against A. retroflexus while exhibiting minimal toxicity to Sorghum bicolor. Structure-activity relationship analysis underscored the importance of trans-4-hydroxy-l-prolines at both the 10th and 13th positions for the herbicidal activities of these peptaibols.

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