文献类型: 外文期刊
作者: Mo, Futao;Sun, Weibo;Zhang, Liping;Zhang, Xiaoyan;La, Yongfu;Xiao, Fan;Jia, Jianlei;Jin, Jipeng
作者机构:
关键词: BMPRIB; litter size; sheep; SNPs; allele distribution
期刊名称: ANIMAL BIOTECHNOLOGY
ISSN: 1049-5398
年卷期: 2021 年
页码:
收录情况: JCR(2021版) ; EI(2021版)
摘要: The BMPRIB gene belongs to the TGF-beta superfamily and is considered to be a regulator of sheep reproductive performance. Single nucleotide polymorphisms (SNPs) of BMPRIB gene in the Small Tail Han, Hu, Mongolian, Oula, Gansu Alpine Fine-wool, Dorper and Australian White sheep were detected by Sanger sequencing. Five SNPs (rs427897187 G > A, rs418841713 A > G, rs159952533 T > C, rs429416173 C > A and rs403555643 A > G) of BMPRIB gene were identified. For rs427897187 G > A, further analysis revealed that genotype GG and GA had 0.26 (p < 0.05) and 0.33 (p < 0.05) litter size less than those with genotype AA in Oula sheep. For rs403555643 A > G, further analysis revealed that genotype GG and AG had 0.65 (p < 0.05) and 0.38 (p < 0.05) litter size more than those with genotype AA in Oula sheep, and genotype GG had 0.56 (p < 0.05) litter size more than those with genotype AA in Mongolian sheep. The results showed that rs427897187 G > A and rs403555643 A > G are potential molecular markers wich could improve litter size of Chinese indigenous sheep and be used in Chinese indigenous sheep breeding.
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