数字农科院2.0

Phenolic compounds from the sclerotia of Inonotus obliquus

文献类型： 外文期刊

作者： Wei Y.-M.; Yang L.; Mei W.-L.; Chen H.-Q.; Cai C.-H.; Li W.; Dong W.-H.; Chen Z.-B.; Dai H.-F.

作者机构：

关键词： 3 hydroxy 1 (4 hydroxy 3;5 dimethoxyphenyl) 3 [4 (3 hydroxypropanoyl) 2;6 dimethoxyphenoxy]propan 1 one; antineoplastic agent; benzene derivative; fungal extract; hydrogen peroxide; inoscavin A; neuroprotective agent; phenol derivative; unclassified drug; hydrogen peroxide; neuroprotective agent; phenol derivative; Article; cell viability; concentration (parameter); controlled study; drug isolation; drug structure; fungal sclerotium; human; human cell; Inonotus obliquus; neuroprotection; oxidative stress; SH-SY5Y cell line; spectroscopy; chemistry; Inonotus; tumor cell line; Cell Line; Tumor; Humans; Hydrogen Peroxide; Inonotus; Neuroprotective Agents; Phenols

期刊名称： Natural Product Research

ISSN： 1478-6419

年卷期： 2022 年 36.0 卷 9.0 期

页码：

收录情况： SCIE（2022版）

摘要： Three phenolic compounds (±1 and 2) including a pair of new enantiomers were isolated from the sclerotia of Inonotus obliquus. Their structures were assigned by extensive spectroscopic analyses. All the compounds were evaluated for the neuroprotective activity against oxidative damage on human neuroblastoma SH-SY5Y cells induced by H2O2. Compound 2 showed remarkable neuroprotective effect and significantly improved the cell viability of SH-SY5Y cells treated by H2O2. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

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