Chemical and physical characterization, stability and antioxidant activity of avicularin/(2-hydroxypropyl)-β-cyclodextrin inclusion complex
文献类型: 外文期刊
作者: Xiaoai Zhu;Yong Cao;Qianchun Deng;Xia Xiang;Jun Xi;Konglong Feng;Zili Gao;Kunlun Liu;Hang Xiao
作者机构:
关键词: (2-Hydroxypropyl)-β-cyclodextrin;Antioxidant ability;Avicularin;Molecular docking
期刊名称: Food Bioscience
ISSN: 2212-4292
年卷期: 2025 年 66 卷
页码:
收录情况: SCIE(2025版) ; ; 农林核心(2024版)
摘要: Avicularin, commonly found in apples and mangos, possessed various health-promoting effects. However, the application of avicularin in functional foods was hindered by its limited water solubility and chemical instability. A freeze-drying-based technique was employed to formulate a complex using avicularin and (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) to improve these properties. The synthesis and structure of the complex were featured by changes in fourier transform infrared spectroscopy (FT-IR), the phase transition recorded by differential scanning calorimetry (DSC), the changes in crystal structures provided by X-ray diffractometry (XRD), the visualized changes in surface morphology determined by scanning electron microscopy (SEM). Additionally, proton nuclear magnetic resonance spectroscopy (1H NMR) analysis and molecular docking simulations demonstrated the A ring of avicularin entered into the cavity of HP-β-CD to form a supramolecular complex. The complex of avicularin resulted in its increased water solubility (22 times), and enhanced chemical stability against heat and alkaline conditions, especially at pH 9,10, with an improvement of up to 50%. Meanwhile, the inclusion complex improved antioxidant activity in the cellular assays, especially at 120 μg/mL, with an improvement of up to 35%. This work provided a solid basis for potential applications of avicularin in functional foods and nutraceuticals.
分类号:
- 相关文献
作者其他论文 更多>>
-
Metabolic profiling of Perilla leaves of different colors: insights into metabolite variation and bioactive compound distribution
作者:Senouwa Segla Koffi Dossou;Qianchun Deng;Feng Li;Lei Wang;Nanjun Jiang;Habtamu Kefale;Rong Zhou;Donghua Li;Meilian Tan;Linhai Wang
关键词:Differentially accumulated metabolites;LC-MS/MS;Leaf color;Metabolite profiling;Perilla
-
The roles of flaxseed gum and its oligosaccharides as stabilizers in zein nanoparticles for apigenin delivery: Stability, antioxidant activity, bioavailability, molecular simulations
作者:Yufei Liu;Ziliang Li;Shuaijun Lu;Shang Gao;Mengting Xu;Ze Yuan;Yue Li;Yiqiao Gao;Jingfang Shangguan;Xia Xiang
关键词:Apigenin;Delivery;Flaxseed gum;Oligosaccharides;Zein
-
Modulation of protein glutaminase α-helix and disulfide bonds in a sunflower pollen microgel microenvironment: A strategy to enhance enzyme activity and stability
作者:Shangwen Chen;Caiyan Tao;Yawen Huang;Ze Zhao;Song Miao;Dengfeng Peng;Yashu Chen;Bin Zhou;Ziyu Deng;Qianchun Deng
关键词:Enzyme stabilizing agent;Microenvironment;Protein glutaminase;Stabilization mechanism;Sunflower pollen microgel
-
High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models
作者:Li Chen;Bangfu Wu;Li Mo;Huimin Chen;Xingzhu Yin;Ying Zhao;Zhao Yu Cui;Feipeng Cui;Liangkai Chen;Qianchun Deng;Chao Gao;Ping Yao;Yanyan Li;Yuhan Tang
关键词:
-
Flaxseed oligosaccharides-derived conjugates for chlorogenic acid delivery with enhanced stability, antioxidant activity, and bioavailability
作者:Nanjie Jiang;Min Li;Guangqi Guo;Yujie Mu;Xiaoyang Xia;Zhenxia Xu;Xia Xiang
关键词:antioxidant activity;bioavailability;chlorogenic acid;conjugates;flaxseed oligosaccharides
-
Polyphenols from Flos Trollii inhibit α-amylase and α-glucosidase: Kinetic analysis and mechanistic insights
作者:Xiaoai Zhu;Kebing Yan;Xianqing Ye;Xia Xiang;Yuan Ru;Yiying Niu;Yage Liu;Jun Xi;Kunlun Liu
关键词:Flos Trollii;Inhibition mechanism;Polyphenols;α-Amylase;α-Glucosidase
-
Adsorption removal of cyclolinopeptide E from linseed oil using sodium chloride-induced walnut shell biochar: Kinetic and mechanism
作者:Tingting Guo;Chuyun Wan;Tieliang Liu;Jianwu Xi;Qianchun Deng;Fenghong Huang;Rui Liu
关键词:Adsorption;Biochar;Debittering;Linseed oil;NaCl immersion;Walnut shell