数字农科院2.0

Integrated transcriptomics and metabolomics revealed improvement of the nervous system in old rats by aspirin eugenol ester

文献类型： 外文期刊

作者： Qi Tao;Ji Feng;Li Ping Fan;Zhi Jie Zhang;Chen Jing Feng;Jian Yong Li;Ya Jun Yang

作者机构：

关键词： Aspirin eugenol ester (AEE);Inflammation;Metabolomics;Neurological diseases;Transcriptomics

期刊名称： Biochimica et Biophysica Acta - Molecular Basis of Disease

ISSN： 0925-4439

年卷期： 2025 年 1871 卷 8 期

页码：

收录情况： SCIE（2025版）

摘要： Elderly groups usually have an inflammatory response in their bodies, and neuroinflammation is the main pathogenic mechanism of neurological diseases. Pharmacological and pharmacodynamic experiments showed that aspirin eugenol ester (AEE) had good anti-inflammatory, anti-oxidant and anti-hyperlipidemic effects. However, whether AEE can prevent neurological diseases in the old companion animal has not been explored. In this study, we selected adolescent rats (6 weeks old) and old rats (18 months old) as the experimental animals for two weeks. The transcriptomics and metabolomics methods were used to explore the effects of AEE on the hippocampal region in the brains of old rats. The related indexes were detected. AEE significantly reduced the levels of pro-inflammatory cytokines and oxidative stress in lipopolysaccharide (LPS) induced microglia of rats. AEE significantly increased the duration of swimming observed in the forced swimming test for older rats, but did not have a significant effect between adolescent rats. Hematoxylin and eosin staining (HE) showed that AEE had no significant effects on the kidney and gastrointestinal tract and could improve liver function in old rats. AEE improved genes and metabolites in the hippocampal region of the old rat brain. Comprehensive analysis of transcriptomics and metabolomics showed that the gene Chacna3 was correlated positively with metabolic phosphatidylethanolamine (PE) and phosphatidylcholine (PC), and the genes Tnfsf10 and Cacna1f were correlated positively with metabolic PE and PC and negatively with eicosapentaenoic acid (Epa). AEE could play positive effects on preventing neurological diseases in old companion animal.

分类号：

  • 相关文献

[1]Multicellular Model Reveals the Mechanism of AEE Alleviating Vascular Endothelial Cell Injury via Anti-Inflammatory and Antioxidant Effects. Ji Feng,Qi Tao,Meng Zhen Li,Zhi Jie Zhang,Qin Fang Yu,Jian Yong Li. 2026

[2]Multi-Omics Approaches for Liver Reveal the Thromboprophylaxis Mechanism of Aspirin Eugenol Ester in Rat Thrombosis Model. Tao Q.,Ma N.,Fan L.,Ge W.,Zhang Z.,Liu X.,Li J.,Yang Y.. 2024

[3]Aspirin eugenol ester alleviates lipopolysaccharide-induced acute lung injury in rats while stabilizing serum metabolites levels. Tao Q.,Zhang Z.-D.,Qin Z.,Liu X.-W.,Li S.-H.,Bai L.-X.,Ge W.-B.,Li J.-Y.,Yang Y.-J.. 2022

[4]Multi-omics reveals aspirin eugenol ester alleviates neurological disease. Qi Tao,Zhen Dong Zhang,Xiao Rong Lu,Zhe Qin,Xi Wang Liu,Shi Hong Li,Li Xia Bai,Bo Wen Ge,Jian Yong Li,Ya Jun Yang. 2023

[5]A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice. Xiao Rong Lu,Qi Tao,Zhe Qin,Xi Wang Liu,Shi Hong Li,Li Xia Bai,Wen Bo Ge,Ya Xian Liu,Jian Yong Li,Ya Jun Yang. 2024

[6]Aspirin Eugenol Ester Alleviates Vascular Endothelial Ferroptosis by Enhancing Antioxidant Ability and Inhibiting the JNK/c-Jun/NCOA4/FTH Signaling Pathway. Feng, Ji,Tao, Qi,Zhang, Zhi-Jie,Yu, Qin-Fang,Yang, Ya-Jun,Li, Jian-Yong. 2025

[7]Platelet Proteomics and Tissue Metabolomics Investigation for the Mechanism of Aspirin Eugenol Ester on Preventive Thrombosis Mechanism in a Rat Thrombosis Model. Qi Tao,Li Ping Fan,Ji Feng,Zhi Jie Zhang,Xi Wang Liu,Zhe Qin,Jian Yong Li,Ya Jun Yang. 2024

[8]Aspirin Eugenol Ester Ameliorates HFD-Induced NAFLD in Mice via the Modulation of Bile Acid Metabolism. Zhi Jie Zhang,Qi Tao,Ji Feng,Qin Fang Yu,Li Ping Fan,Zi Hao Wang,Wen Bo Ge,Jian Yong Li,Ya Jun Yang. 2025

[9]Sodium butyrate promotes gastrointestinal development of preweaning bull calves via inhibiting inflammation, balancing nutrient metabolism, and optimizing microbial community functions. Huiyue Zhong,Wenjing Yu,Min Wang,Bo Lin,Xuezhao Sun,Nan Zheng,Jiaqi Wang,Shengguo Zhao. 2023

[10]ANGPTL8/betatrophin improves glucose tolerance in older mice and metabolomic analysis reveals its role in insulin resistance in HepG2 cells. Fangfang Xu,Nan Wang,Gangqiang Li,Dandan Tian,Xiaoyang Shi. 2021

[11]Morchella importuna Polysaccharides Alleviate Carbon Tetrachloride-Induced Hepatic Oxidative Injury in Mice. Yingyin Xu,Liyuan Xie,Jie Tang,Xiaolan He,Zhiyuan Zhang,Ying Chen,Jie Zhou,Bingcheng Gan,Weihong Peng. 2021

[12]The Flavonoid Extract of Polygonum viviparum L. Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis by Regulating Intestinal Flora Homeostasis and Uric Acid Levels Through Inhibition of PI3K/AKT/NF-κB/IL-17 Signaling Pathway. Liu, Haoyu,Yang, Zhen,Chen, Qian,Zhang, Hongjuan,Liu, Yu,Wu, Di,Shao, Dan,Wang, Shengyi,Hao, Baocheng. 2025

[13]Soybean Omics and Biotechnology in China. Guo, Yong,Wang, Xiao-Bo,He, Wei,Zhou, Guo-An,Guo, Bing-Fu,Zhang, Le,Liu, Zhang-Xiong,Luo, Zhong-Qin,Wang, Li-Hui,Qiu, Li-Juan. 2011

[14]Germplasm resource evaluation and the underlying regulatory mechanisms of the differential copper stress tolerance among Vitis species. Xia J.,Chen C.,Liu T.,Liu C.,Liu S.,Fang J.,Shangguan L.. 2023

[15]Application of omics technology in the research on edible fungi. Cao L.,Zhang Q.,Miao R.,Lin J.,Feng R.,Ni Y.,Li W.,Yang D.,Zhao X.. 2023

[16]Characteristics of Transcriptome and Metabolome Concerning Intramuscular Fat Content in Beijing Black Pigs. Xinhua Hou,Run Zhang,Man Yang,Naiqi Niu,Wencheng Zong,Liyu Yang,Huihui Li,Renda Hou,Xiaoqing Wang,Ligang Wang,Xin Liu,Lijun Shi,Fuping Zhao,Lixian Wang,Longchao Zhang. 2023

[17]Transcriptome-metabolome analysis reveals how sires affect meat quality in hybrid sheep populations. Bowen Chen,Yaojing Yue,Jianye Li,Jianbin Liu,Chao Yuan,Tingting Guo,Dan Zhang,Bohui Yang,Zengkui Lu. 2022

[18]Integrative analysis of transcriptomics and metabolomics to reveal the melanogenesis pathway of muscle and related meat characters in Wuliangshan black-boned chickens. Tengfei Dou,Shixiong Yan,Lixian Liu,Kun Wang,Zonghui Jian,Zhiqiang Xu,Jingying Zhao,Qiuting Wang,Shuai Sun,Mir Zulqarnain Talpur,Xiaohua Duan,Dahai Gu,Yang He,Yanli Du,Alsoufi Mohammed Abdulwahid,Qihua Li,Hua Rong,Weina Cao,Zhengchang Su,Guiping Zhao,Ranran Liu,Sumei Zhao,Ying Huang,Marinus F.W. Te Pas,Changrong Ge,Junjing Jia. 2022

[19]Metabolomics and Transcriptomics Provide Insights into Anthocyanin Biosynthesis in the Developing Grains of Purple Wheat (Triticum aestivum L.). Fang Wang,Guangsi Ji,Zhibin Xu,Bo Feng,Qiang Zhou,Xiaoli Fan,Tao Wang. 2021

[20]Integrative Analysis of Liver Metabolomics and Transcriptomics Reveals Oxidative Stress in Piglets with Intrauterine Growth Restriction. Gao H.,Chen X.,Zhao J.,Xue Z.,Zhang L.,Zhao F.,Wang B.,Wang L.. 2022

作者其他论文 更多>>