数字农科院2.0

Effect of RNA-binding protein nuclear accommodation of mitochondria 8-FgNam8 on deoxynivalenol production and virulence of mycotoxigenic Fusarium graminearum

文献类型： 外文期刊

作者： Yunan Jiang;Haoxue Xia;Yaru He;Ying Wang;Wende Liu;Guangfei Tang

作者机构：

关键词： DON;Pathogenicity;RNA-binding proteins

期刊名称： International Journal of Biological Macromolecules

ISSN： 0141-8130

年卷期： 2025 年 318 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： RNA-binding proteins (RBPs) are important regulators in RNA metabolism and gene expression in eukaryotes. Emerging studies support that RBPs play important roles in human development, metabolism and various diseases. However, the function of fungal RBPs is less identified and understood. The present study identifies an RBP FgNam8 which is U1 auxiliary component nuclear accommodation of mitochondria 8 (Nam8). The FgNam8 contains three RNA recognition motifs (RRM) and localizes to the cytoplasm and nucleus in F. graminearum. The ΔFgNam8 is reduced in vegetative growth and production of conidia. RNA-seq analyses show multiple RNA-associated biological processes and secondary metabolite biosynthesis pathways are altered in the ΔFgNam8. Furthermore, ΔFgNam8 is significantly reduced in deoxynivalenol (DON) production and virulence. More importantly, we verify the NDR (nuclear Dbf2-related) protein kinase FgCot1 interacts with FgNam8. Taken together, our results indicate that FgNam8 is important for the vegetative development, conidia production, DON production and virulence of F. graminearum, which may help to provide a candidate target for the treatment of Fusarium disease.

分类号：

  • 相关文献

[1]Ribonomics Approaches to Identify RBPome in Plants and Other Eukaryotes: Current Progress and Future Prospects. Haroon, Muhammad,Afzal, Rabail,Zafar, Muhammad Mubashar,Zhang, Hongwei,Li, Lin. 2022

[2]Progress in genome-wide identification of RBPs and their role in mitigating stresses, and growth in plants. Muhammad Haroon,Hala Tariq,Rabail Afzal,Muhammad Anas,Shanza Nasar,Neha Kainat,Sajid Fiaz,Uswa Irfan,Fahad Idrees,Muhammad Mubashar Zafar. 2023

[3]Nucleocapsid protein captures DDX5 and RNMT facilitating viral RNA synthesis and viral protein translation for coronavirus replication. Liu, Yuchang,Kong, Ning,Yang, Xinyu,Qin, Wenzhen,Wang, Yahe,Wang, Chen,Sun, He,Wang, Jiarui,Gao, Ao,Zheng, Dongfang,Tong, Wu,Yu, Hai,Zheng, Hao,Tong, Guangzhi,Shan, Tongling. 2026

[4]室温下麦粒中脱氧雪腐镰刀菌烯醇(DON)及其隐蔽型(D3G)毒素累积分析. 靳梦曈,王建华,林善海,赵勇,孙文烁. 2015

[5]脱氧雪腐镰刀菌烯醇(DON)在小麦籽粒中的积累分析. 刘太国,张敏,陈万权. 2012

[6]脱氧雪腐镰刀菌烯醇(DON)的毒性及其生物转化研究进展. 常敬华,赵月菊,邢福国,朱玉昌,刘阳. 2014

[7]呕吐毒素脱毒菌对生长猪小肠内Hsp70分布和表达的影响. 董永芳,王金全,陈红菊,杨婉莹,黄丽波,王春阳. 2020

[8]小麦赤霉病菌在侵染植株中的生物量和DON的定量分析. 何晨阳. 2006

[9]面包加工对脱氧雪腐镰刀菌烯醇(DON)的降解效果. 常敬华,李金寒,赵月菊,朱玉昌,丁宁,刘阳. 2015

[10]高温胁迫对禾谷镰孢生长和致病力的影响. 徐庆,王奥霖,聂晓,刘伟,张昊,曹世勤,范洁茹,周益林. 2024

[11]A novel biosensor regulated by the rotator of F0F1-ATPase to detect deoxynivalenol rapidly. Wang, Peirong,Yue, Jiachang,Zhao, Yueliang,Wang, Feng,Zhou, Hongjie,Li, Weiming,Ha, Yiming. 2012

[12]Development of a simple and convenient cell-based electrochemical biosensor for evaluating the individual and combined toxicity of DON, ZEN, and AFB(1). Xia, Shuang,Pi, Fuwei,Zhang, Yinzhi,Li, Yun,Wang, Jiasheng,Sun, Xiulan,Zhu, Pei,Li, Yun.

[13]Development Of A Simple And C.onvenient Cell-Based Electrochemical Biosensor F or Evaluating The Individual And Combined Toxicity Of Don, Zen, And Afb(1). Xia, SA, Zhu, P, Pi, FW, Zhang, YZ, Li, Y, Wang, JS, Sun, XL. 2017

[14]Exploring Allium mongolicum Regel flavonoids alleviation of deoxynivalenol-induced gut inflammation and flesh-quality improvement based on muscle-intestinal axis in a Channa argus model. Zhe Yu,Zhuang Xiong,Yi Wang,Zhi Qiang Gao,Ke Xin Lu,Ying Zhang,Mu Yang Li,Yuan Xi Yue. 2025

[15]A polyphasic approach for studying Colletotrichum. Cai, L.,Hyde, K. D.,Hyde, K. D.,Phoulivong, S.,Prihastuti, H.,Taylor, P. W. J.,Weir, B. S.,McKenzie, E. H. C.,Johnston, P. R.,Waller, J. M.,Abang, M. M.,Zhang, J. Z.,Yang, Y. L.,Liu, Z. Y.,Shivas, R. G.. 2009

[16]Complete genome sequence of endophytic nitrogen-fixing Klebsiella variicola strain DX120E. Lin, Li,Li, Yangrui,Yang, Litao,Lin, Li,Li, Yangrui,Yang, Litao,Lin, Li,Li, Yangrui,Yang, Litao,Lin, Li,Li, Yangrui,Yang, Litao,Wei, Chunyan,Li, Yangrui,Yang, Litao,Chen, Mingyue,Wang, Hongcheng,Li, Yuanyuan,An, Qianli,Yang, Litao. 2015

[17]Construction and Virulence of Filamentous Hemagglutinin Protein B1 Mutant of Pasteurella multocida in Chickens. Guo Dong-chun,Sun Yan,Zhang Ai-qin,Liu Jia-sen,Lu Yan,Liu Pei-xin,Yuan Dong-wei,Jiang Qian,Si Chang-de,Sun Yan,Zhang Ai-qin,Lu Yan. 2014

[18]C-terminal truncation of the transmembrane protein of an attenuated lentiviral vaccine alters its in vitro but not in vivo replication and weakens its potential pathogenicity. Jiang, Cheng-Gang,Gao, Xu,Ma, Jian,Lin, Yue-Zhi,Wang, Xue-Feng,Zhao, Li-Ping,Zhou, Jian-Hua,Jiang, Cheng-Gang,Liu, Di,Hua, Yue-Ping,Gao, Xu. 2011

[19]Isolation and Characterization of a Moderately Virulent Classical Swine Fever Virus Emerging in China. Luo, Y.,Ji, S.,Liu, Y.,Lei, J. -L.,Xia, S. -L.,Wang, Y.,Du, M. -L.,Shao, L.,Meng, X. -Y.,Zhou, M.,Sun, Y.,Qiu, H. -J.,Ji, S..

[20]Synergistic effects of sequential infection with highly pathogenic porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. Fan, Peihu,Wei, Yanwu,Guo, Longjun,Wu, Hongli,Huang, Liping,Liu, Jianbo,Liu, Changming. 2013

作者其他论文 更多>>