数字农科院2.0

Pathogenicity and horizontal transmission evaluation of a novel isolated African swine fever virus strain with a three-large-fragment-gene deletion

文献类型： 外文期刊

作者： Han Gao;Dongdong Di;Qianwen Wu;Jie Li;Xing Liu;Zhiying Xu;Sijia Xu;Chengyu Wu;Lang Gong;Yankuo Sun;Guihong Zhang;Hongjun Chen;Heng Wang

作者机构：

关键词： African swine fever virus (ASFV);Animal study;Attenuation;Gene-deleted strains;Pathogenicity

期刊名称： Veterinary Microbiology

ISSN： 0378-1135

年卷期： 2024 年 290 卷

页码：

收录情况： SCIE（2024版）

摘要： African swine fever has caused substantial economic losses to China`s pig industry in recent years. Currently, the highly pathogenic African swine fever virus strain of genotype II is predominantly circulating in China, accompanied by a series of emerging isolates displaying unique genetic variations. The pathogenicity of these emerging strains is still unclear. Recently, a novel ASFV strain with a distinguishable three-large-fragment gene deletion was obtained from the field specimens, and its in vivo pathogenicity and transmission were evaluated in this study. The animal experiment involved inoculating a high dose of YNFN202103 and comparing its effects with those of the highly pathogenic strain GZ201801_2. Results showed that pigs infected by YNFN202103 exhibited significantly prolonged onset and survival time, lower viremia levels, and less severe histopathological lesions compared to GZ201801_2. These findings contributed valuable insights into the pathogenicity and transmission of ASFV and its prevention and eradication strategies in practical settings.

分类号：

  • 相关文献

[1]Serial cell culture passaging in vitro led to complete attenuation and changes in the characteristic features of a virulent porcine deltacoronavirus strain. Zhang, Liping,Yu, Ruiming,Wang, Lianshun,Zhang, Zhongwang,Lu, Yanzhen,Zhou, Peng,Wang, Yonglu,Guo, Huichen,Pan, Li,Liu, Xinsheng. 2024

[2]Pathogenicity Evaluation and Virulence Gene Identification of an Attenuated Duck Enteritis Virus. Xiaona Shi,Haibin Zhuang,Dun Shuo,Luzhao Li,Shenghui Pan,Zihua Wu,Mei Tang,Wenxia Yang,Qinfang Liu,Chunxiu Yuan,Dawei Yan,Xue Pan,Bangfeng Xu,Zhifei Zhang,Minghao Yan,Qiaoyang Teng,Zejun Li. 2025

[3]Characterization of a cell-adapted completely attenuated genotype GIIa porcine epidemic diarrhea virus strain. Ruiming Yu,Liping Zhang,Dongsheng Wang,Jun Yang,Peng Zhou,Yuhan Wen,Mingxia Li,Yingjie Bai,Zhongwang Zhang,Yousheng Peng,Yanzhen Lu,Dan Li,Jian He,Yonglu Wang,Huichen Guo,Li Pan,Xinsheng Liu. 2025

[4]Carry-over of melamine from feed to eggs and body tissues of laying hens. Dong, X. F.,Liu, S. Y.,Tong, J. M.,Zhang, Q.. 2010

[5]PI3K–Akt pathway-independent PIK3AP1 identified as a replication inhibitor of the African swine fever virus based on iTRAQ proteomic analysis. Bo Yang,Yu Hao,Jinke Yang,Dajun Zhang,Xijuan Shi,Xing Yang,Dengshuai Zhao,Wenqian Yan,Lingling Chen,Guohui Chen,Xintian Bie,Xiangtao Liu,Haixue Zheng,Keshan Zhang. 2023

[6]Identification of monoclonal antibody targeting epitope on p72 trimeric spike of African swine fever virus. Duan, Xulai,Liu, Yingnan,Chen, Zongyan,Xie, Zhenhua,Tian, Chuanwen,Li, Yao,Lv, Lu,Wang, Rongrong,Liu, Jingyi,Chen, Hongjun. 2023

[7]Transcriptome Profiling Reveals Features of Immune Response and Metabolism of Acutely Infected, Dead and Asymptomatic Infection of African Swine Fever Virus in Pigs. Hualin Sun,Qingli Niu,Jifei Yang,Yaru Zhao,Zhancheng Tian,Jie Fan,Zhonghui Zhang,Yiwang Wang,Shuxian Geng,Yulong Zhang,Guiquan Guan,David T. Williams,Jianxun Luo,Hong Yin,Zhijie Liu. 2021

[8]FoxJ1 inhibits African swine fever virus replication and viral S273R protein decreases the expression of FoxJ1 to impair its antiviral effect. Caina Ma,Shasha Li,Fan Yang,Weijun Cao,Huisheng Liu,Tao Feng,Keshan Zhang,Zixiang Zhu,Xiangtao Liu,Yonghao Hu,Haixue Zheng. 2022

[9]Establishment and Application of a Quantitative PCR Method for E248R Gene of African Swine Fever Virus. Li, Liwei,Du, Nannan,Chen, Jinxia,Zhang, Kuan,Tong, Wu,Zheng, Haihong,Zhao, Ran,Tong, Guangzhi,Gao, Fei. 2022

[10]LAMP assay coupled with CRISPR/Cas12a system for portable detection of African swine fever virus. Yang, Bo,Shi, Zhengwang,Ma, Yuan,Wang, Lijuan,Cao, Liyan,Luo, Juncong,Wan, Ying,Song, Rui,Yan, Yiyong,Yuan, Kehu,Tian, Hong,Zheng, Haixue. 2021

[11]Identification of African swine fever virus MGF505-2R as a potent inhibitor of innate immunity in vitro. Huaguo Huang,Wen Dang,Zhengwang Shi,Mingyang Ding,Fan Xu,Tao Li,Tao Feng,Haixue Zheng,Shuqi Xiao. 2023

[12]OGG1 inhibition suppresses African swine fever virus replication. Fan, Jie,Lv, Xinqian,Yang, Saixia,Geng, Shuxian,Yang, Jifei,Zhao, Yaru,Zhang, Zhonghui,Liu, Zhijie,Guan, Guiquan,Luo, Jianxun,Zeng, Qiaoying,Yin, Hong,Niu, Qingli. 2023

[13]ASFV transcription reporter screening system identifies ailanthone as a broad antiviral compound. Zhang, Yuhang,Zhang, Zhenjiang,Zhang, Fan,Zhang, Jiwen,Jiao, Jun,Hou, Min,Qian, Nianchao,Zhao, Dongming,Zheng, Xiaofeng,Tan, Xu. 2023

[14]African Swine Fever Virus MGF-110-9L-deficient Mutant Has Attenuated Virulence in Pigs. Dan Li,Yinguang Liu,Xiaolan Qi,Yuan Wen,Pan Li,Zhao Ma,Yongjie Liu,Haixue Zheng,Zhijie Liu. 2021

[15]A chemiluminescent magnetic microparticle immunoassay for the detection of antibody against African swine fever virus. Shi, Zhengwang,Cao, Liyan,Luo, Juncong,Zhou, Gaijing,Zuo, Qingshan,Liu, XiangTao,Hu, Yonghao,Tian, Hong,Zheng, Haixue. 2023

[16]Target capture sequencing for the first Nigerian genotype I ASFV genome. Adeniyi C. Adeola,Pam D. Luka,Xiang Xiang Jiang,Zheng Fei Cai,Olufunke O. Oluwole,Xian Shi,Bukola M. Oladele,Temilola O. Olorungbounmi,Bamidele Boladuro,Oladipo Omotosho,Victor M.O. Okoro,Philip M. Dawuda,Sunday C. Olaogun,Oscar J. Sanke,Hai Bing Xie,Richard P. Bishop,Jianlin Han,Jianbo Li,Ya Ping Zhang,Min Sheng Peng. 2023

[17]Fangchinoline Inhibits African Swine Fever Virus Replication by Suppressing the AKT/mTOR/NF-κB Signaling Pathway in Porcine Alveolar Macrophages. Guanming Su,Xiaoqun Yang,Qisheng Lin,Guoming Su,Jinyi Liu,Li Huang,Weisan Chen,Wenkang Wei,Jianxin Chen. 2024

[18]Structure-function insights into the dual role of African swine fever virus pB318L: A typical geranylgeranyl-diphosphate synthase and a nuclear import protein. Zhao, Hai-Fan,Wang, Ying,Liu, Xiao-Hong,Liu, Xian-Hui,Geng, Zhi,Gao, Zeng-Qiang,Huang, Li,Weng, Chang-Jiang,Dong, Yu-Hui,Zhang, Heng. 2025

[19]Cascade signal amplification in hierarchical MOFzymes for revolutionizing electrochemical diagnostics of African swine fever virus. Zhao, Xiaoping,Deng, Yuanjie,Meng, Lingjie,Wang, Mingzhu,Tian, Hong,Wang, Yanxin,Zhou, Chengru,Zhu, Zixiang,Zheng, Haixue. 2025

[20]African swine fever virus MGF360-9L degrades DDX20 through the Rab1A-dependent autophagy pathway to antagonize its antiviral effect. He, Lu,Fan, Xuxu,Zhu, Zhaoyu,Pei, Danshi,Wang, Yizhuo,Li, Xizhong,Ren, Qingfeng,Zheng, Haixue,Li, Weiwei,Zhu, Zixiang. 2025

作者其他论文 更多>>