数字农科院2.0

Differential gene expression drives muscle metabolic and structural differences in Liang Guang small spotted vs. large white pigs

文献类型： 外文期刊

作者： Zheng Feng;Wen Jing Wang;Nan Wang;Shun Shun Chi;Yu Lian Mu;Zhi Guo Liu

作者机构：

关键词： Liang Guang Small Spotted pigs;Longissimus dorsi muscle;Pig;RNA sequencing;Whole-transcriptome sequencing

期刊名称： Scientific Reports

ISSN： 2045-2322

年卷期： 2025 年 15 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： The Liang Guang Small Spotted (LGSS) pigs, an indigenous Chinese breed, are reported to exhibit desirable muscle attributes such as high intramuscular fat deposition, smaller muscle fiber diameter, and superior water-holding capacity. However, despite these merits, its commercial utility is constrained by suboptimal growth rates and diminished carcass yield. To explore transcriptomic differences potentially associated with distinct muscle phenotypes and identify targets for productivity enhancement, we performed integrated transcriptomic analysis of longissimus dorsi muscles (LDMs) from LGSS and Large White (LW) pigs. We characterized differentially expressed (DE) mRNAs, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), which were primarily enriched in key biological processes including glycolysis and carbon metabolism, structural organization, as well as signaling cascades such as HIF-1, AMPK, and PI3K-Akt. This study uncovers significant transcriptomic distinctions and identifies candidate regulatory molecules in LGSS pigs, offering potential biomarkers and a framework for future functional studies aimed at genetic improvement.

分类号：

  • 相关文献

[1]Integrative Analysis of Proteomics and Transcriptomics of Longissimus dorsi with Different Feeding Systems in Yaks. Ma X.,Guo X.,La Y.,Wu X.,Chu M.,Bao P.,Yan P.,Liang C.. 2023

[2]The microRNA expression profile in porcine skeletal muscle is changed by constant heat stress. Hao, Y.,Liu, J. R.,Yang, P. G.,Feng, Y. J.,Cui, Y. J.,Yang, C. H.,Gu, X. H.,Liu, J. R.,Zhang, Y..

[3]Competing endogenous RNA network construction based on long non-coding RNAs, microRNAs, and mRNAs related to fat deposition in Songliao black swine. Liu, Yibing,Xing, Kai,Ao, Hong,Zhang, Fengxia,Zhao, Xitong,Liu, Huatao,Shi, Yong,Yu, Ying,Wang, Chuduan. 2023

[4]Incorporating genome-wide and transcriptome-wide association studies to identify genetic elements of longissimus dorsi muscle in Huaxi cattle. Mang Liang,Bingxing An,Tianyu Deng,Lili Du,Keanning Li,Sheng Cao,Yueying Du,Lingyang Xu,Lupei Zhang,Xue Gao,Yang Cao,Yuming Zhao,Junya Li,Huijiang Gao. 2023

[5]A comprehensive study on the longissius dorsi muscle of Ashdan yaks under different feeding regimes based on transcriptomic and metabolomic analyses. Wang, Tong,Ma, Xiaoming,Zheng, Qingbo,Ma, Chaofan,Zhang, Zhilong,Pan, Heping,Guo, Xian,Wu, Xiaoyun,Chu, Min,Liang, Chunnian,Yan, Ping. 2024

[6]Dissection Of Myogenic Differentiation Signatures I.n Chickens By Rna-Seq A nalysis. Wang, Jinyu,Li, Tingting,Zhang, Genxi,Wu, Pengfei,Li, Guohui,Duan, Lian,Liu, Qiuhong. 2018

[7]Comparative transcriptome sequencing of tolerant rice introgression line and its parents in response to drought stress. Huang, Liyu,Zhang, Fan,Zhang, Fan,Wang, Wensheng,Zhou, Yongli,Fu, Binying,Li, Zhikang,Zhang, Fan. 2014

[8]De novo assembly and characterization of skin transcriptome using RNAseq in sheep (Ovis aries). Yue, Y. J.,Yang, B. H.,Yue, Y. J.,Liu, J. B.,Yang, M.,Han, J. L.,Guo, T. T.,Guo, J.,Feng, R. L.,Yang, B. H.. 2015

[9]Functional and RNA-Sequencing Analysis Revealed Expression of a Novel Stay-Green Gene from Zoysia japonica (ZjSGR) Caused Chlorophyll Degradation and Accelerated Senescence in Arabidopsis. Teng, Ke,Chang, Zhihui,Liang, Xiaohong,Xu, Lixin,Chao, Yuehui,Han, Liebao,Li, Xiao,Sun, Xinbo. 2016

[10]Analysis of sea-island cotton and upland cotton in response to Verticillium dahliae infection by RNA sequencing. Quan Sun,Huaizhong Jiang,Xiaoyan Zhu,Weina Wang,Xiaohong He,Yuzhen Shi,Youlu Yuan,Xiongming Du,Yingfan Cai. 2013

[11]Comparative Transcriptome Analysis between Broccoli (Brassica oleracea var. italica) and Wild Cabbage(Brassica macrocarpa Guss.) in Response to Plasmodiophorabrassicae during Different Infection Stages. Zhang, Xiaoli,Liu, Yumei,Fang, Zhiyuan,Li, Zhansheng,Yang, Limei,Zhuang, Mu,Zhang, Yangyong,Lv, Honghao. 2016

[12]MicroRNA expression profiling of primary sheep testicular cells in response to bluetongue virus infection. Du, Junzheng,Gao, Shandian,Tian, Zhancheng,Xing, Shanshan,Huang, Dexuan,Zhang, Guorui,Zheng, Yadong,Liu, Guangyuan,Luo, Jianxun,Chang, Huiyun,Yin, Hong,Yin, Hong.

[13]Comparative transcriptome analyses indicate enhanced cellular protection against FMDV in PK15 cells pretreated with IFN-gamma. Fu, Yin,Zhu, Zesen,Liu, Jing,Chen, Huiyong,Fu, Yin,Zhu, Zesen,Liu, Jing,Chen, Huiyong,Chang, Huiyun,Liu, Zaixin.

[14]Comparative Transcriptome Analysis to Investigate the Immunotoxicity Mechanism Triggered by Dimethomorph on Human Jurkat T Cell Lines. Yun Cheng Li,Shu Yan Liu,Fan Bing Meng,Shu Hui Xu,Jing Qiu,Yong Zhong Qian,Yan Yang Xu,Yun Li. 2022

[15]Transcriptomics Analysis Of The Flowering R.egulatory Genes Involved In T he Herbicide Resistance Of Asia Minor Bluegrass (Polypogon Fugax). Zhou, FY, Zhang, Y, Tang, W, Wang, M, Gao, TC. 2017

[16]Integrated Transcriptome and Metabolome Analysis to Identify Sugarcane Gene Defense against Fall Armyworm (Spodoptera frugiperda) Herbivory. Ao Mei Li,Miao Wang,Zhong Liang Chen,Cui Xian Qin,Fen Liao,Zhen Wu,Wei Zhong He,Prakash Lakshmanan,You Qiang Pan,Dong Liang Huang. 2022

[17]GhMYB102 promotes drought resistance by regulating drought-responsive genes and ABA biosynthesis in cotton (Gossypium hirsutum L.). Liu R.,Shen Y.,Wang M.,Liu R.,Cui Z.,Li P.,Wu Q.,Shen Q.,Chen J.,Zhang S.,Liu S.,Ma H.,Pang C.,Ge C.. 2023

[18]Deciphering the Genetic Basis of Root and Biomass Traits in Rapeseed (Brassica napus L.) through the Integration of GWAS and RNA-Seq under Nitrogen Stress. Nazir Ahmad,Bin Su,Sani Ibrahim,Lieqiong Kuang,Ze Tian,Xinfa Wang,Hanzhong Wang,Xiaoling Dun. 2022

[19]Cry9A and Vip3A protein-induced transcriptional changes correspond to their synergistic damage to the midgut of Chilo suppressalis. Zeyu Wang,Wenquan Yang,Chuanlin Yin,Weihua Ma,Min Liao,Fei Li,Jie Zhang. 2023

[20]Transcriptome analysis of tolerant and susceptible maize genotypes reveals novel insights about the molecular mechanisms underlying drought responses in leaves. Joram Kiriga Waititu,Xingen Zhang,Tianci Chen,Chunyi Zhang,Yang Zhao,Huan Wang. 2021

作者其他论文 更多>>