数字农科院2.0

Prolyl endopeptidase is a multifunctional host factor required for FMDV infection

文献类型： 外文期刊

作者： Kun Ma;Rongzeng Hao;Tianran Liu;Yi Ru;Tao Feng;Xiaolan Qi;Yuzhe Wang;Bingzhou Lu;Sen Wu;Dan Li;Ran Zhang;Yaofeng Zhao;Haixue Zheng

作者机构：

关键词： Foot-and-mouth disease virus;Innate immunity;Prolyl endopeptidase;Pumilio protein 1;Virus life cycle

期刊名称： Cellular and Molecular Life Sciences

ISSN： 1420-682X

年卷期： 2025 年 82 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Foot-and-mouth disease virus (FMDV) poses a significant global threat to livestock production, underscoring the urgent need for a deeper understanding of virus-host interactions to develop effective prevention strategies. In this study, we identify prolyl endopeptidase (PREP) as a critical host factor in FMDV infection. We demonstrate that PREP knockout (PREP-KO) significantly enhances host resistance to FMDV infection by upregulating the expression of RIG-I and MDA5 mRNA. Specifically, PREP-KO destabilizes the PUM1 protein via proteasomal and apoptotic degradation pathways, thereby increasing RIG-I promoter activity. Additionally, PREP-KO inhibits the FMDV life cycle at the replication stage. In vivo experiments further reveal that PREP inhibition or knockout provides protection against FMDV infection following a sublethal challenge in mice. Our findings identify PREP as a novel antiviral target, providing valuable insights for development of antiviral therapies and breeding of disease-resistant livestock.

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