数字农科院2.0

Characteristics of Polyphenols of Black Hulless Barley Bran and Its Anti-Diabetic Activity

文献类型： 外文期刊

作者： Junlin Deng;Tinghui Liu;Chen Xia;Litao Tong;Chunmei Gu;Zhiqiang Shi;Yuehang Yang;Ruiling Zhan;Zhuoya Xiang;Jian Chen;Yan Wan;Manyou Yu

作者机构：

关键词： black hulless barley bran;intestinal microbiota;polyphenols;T2DM;transcriptome

期刊名称： Foods

ISSN： 2304-8158

年卷期： 2025 年 14 卷 17 期

页码：

收录情况： SCIE（2025版）

摘要： Polyphenols play a crucial role in promoting human health. This study aims to investigate the polyphenols of black hulless barley bran (HBP) and evaluate their anti-diabetic mechanisms in vivo. Using UPLC-QTOF-MS/MS, 27 compounds were identified in HBP, including four phenolic acids, 14 flavonoids, and nine anthocyanidins. High contents of Chrysoeriol 7-O-glucuronide (42.09 mg/g), Cyanidin 3-O-glucoside (21.02 mg/g), and Cyanidin 3-O-(6″-O-malonyl)-glucoside (24.45 mg/g) were quantified via UPLC in HBP. Administration of HBP significantly reduced fasting blood glucose (FBG), improved glucose intolerance and lipid profiles, and alleviated liver and pancreatic damage in type 2 diabetic (T2DM) mice. Furthermore, it enhanced serum antioxidant enzyme activities and modulated inflammatory cytokines. Transcriptomic analysis revealed that HBP influenced signal transduction and the immune system, particularly in key signaling pathways, including Hippo, TGF-beta, HIF-1, and p53, associated with T2DM. Although HBP had minimal impact on gut microbiota diversity and SCFA levels, it presents a promising candidate for T2DM intervention through its multifaceted mechanisms.

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