数字农科院2.0

Rumen microbiome associates with postpartum ketosis development in dairy cows: a prospective nested case-control study

文献类型： 外文期刊

作者： Kong, Fanlin;Wang, Shuo;Zhang, Yijia;Li, Chen;Dai, Dongwen;Guo, Cheng;Wang, Yajing;Cao, Zhijun;Yang, Hongjian;Bi, Yanliang;Wang, Wei;Li, Shengli

作者机构：

关键词： Dairy cow;Peripartum period;Energy metabolism;Ketosis;Rumen microbiome;Glucogenic precursors

期刊名称： MICROBIOME

ISSN： 2049-2618

年卷期： 2025 年 13 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： BackgroundApproximately, one-third of dairy cows suffer from postpartum diseases. Ketosis is considered an important inducer of other postpartum diseases by disrupting energy metabolism. Although the rumen microbiome may be involved in the etiology of ketosis by supplying volatile fatty acids, the rumen environmental dynamics of ketosis cows are unclear. Using multi-omics, this study aimed to elucidate changes in the rumen microbiome during parturition of ketosis cows and the association between the rumen microbiome and host energy metabolism. The study included 810 rumen content samples and 789 serum samples from day - 21 and 21 relative to calving day from 61 ketosis cows and 84 healthy cows.ResultsIn ketosis cows, the rumen bacterial composition after parturition changed dramatically and needed a longer time to restore. The molar proportions of propionate were lower in ketosis cows than those in healthy cows on days 3 and 7 and negatively correlated with the serum beta-hydroxybutyrate (BHBA) levels. The fermentation sub-pathway of propionate metabolism and partial glucogenic amino acid pathways were downregulated on day 3. Prevotella, UBA1066, and microbiota diversity indices regulate serum BHBA and glucose (GLU) levels via arginine, alanine, glycine, or propionate. Propionate administration to ketosis cows potentially decreased the serum BHBA concentration.ConclusionsCollectively, we found rumen disruption happened after calving among ketosis cows, and insufficient glycogenic substrates, such as propionate, may be related to ketosis development. The study findings have implications for the relationship between rumen microbiome dynamics and host energy metabolism, which lays the foundation for the future rumen microbiome investigation for improving postpartum management in cows.CJRj3W8kbqfjCAahA4_csMVideo AbstractConclusionsCollectively, we found rumen disruption happened after calving among ketosis cows, and insufficient glycogenic substrates, such as propionate, may be related to ketosis development. The study findings have implications for the relationship between rumen microbiome dynamics and host energy metabolism, which lays the foundation for the future rumen microbiome investigation for improving postpartum management in cows.CJRj3W8kbqfjCAahA4_csMVideo Abstract

分类号：

  • 相关文献

[1]Major Nutritional Metabolic Alterations Influencing the Reproductive System of Postpartum Dairy Cows. Sammad, Abdul,Khan, Muhammad Zahoor,Abbas, Zaheer,Hu, Lirong,Ullah, Qudrat,Wang, Yajing,Zhu, Huabin,Wang, Yachun. 2022

[2]Screening for potential warning biomarkers in cows with ketosis based on host–microbiota co-metabolism analysis. Zhenlong Du,Zhengzhong Luo,Yixin Huang,Tao Zhou,Li Ma,Dan Wu,Xueping Yao,Liuhong Shen,Shumin Yu,Kang Yong,Zuoting Yan,Suizhong Cao. 2024

[3]The Dynamic Transcription Profiles of Proliferating Bovine Ovarian Granulosa When Exposed to Increased Levels of β-Hydroxybutyric Acid. Jianfei Gong,Shanjiang Zhao,Nuo Heng,Yi Wang,Zhihui Hu,Huan Wang,Huabin Zhu. 2022

[4]Association between Tryptophan Metabolism and Inflammatory Biomarkers in Dairy Cows with Ketosis. Zhengzhong Luo,Kang Yong,Zhenlong Du,Yixin Huang,Tao Zhou,Li Ma,Xueping Yao,Liuhong Shen,Shumin Yu,Zuoting Yan,Suizhong Cao. 2023

[5]Sirtuin 3 regulation: a target to alleviate β-hydroxybutyric acid-induced mitochondrial dysfunction in bovine granulosa cells. Shanjiang Zhao,Jianfei Gong,Yi Wang,Nuo Heng,Huan Wang,Zhihui Hu,Haoyu Wang,Haobo Zhang,Huabin Zhu. 2023

[6]Optimal Calcium Propionate Supplementation in Early-Lactation Dairy Cows Improves Milk Yield and Alters Milk Composition. Zhang, Fan,Tang, Xiangfang,Xiong, Benhai. 2025

[7]Metagenomic insights into the rumen epithelial integrity responses to the vitamin B1 supplement under high-concentrate diets treatments. Ma P.,Sun C.,Liu M.,You H.,Shen Y.,Kang Y.,Sun Y.,Yang Z.,Ma P.,Yang L.,Xue F.. 2022

[8]Long term effects of artificial rearing before weaning on the growth performance, ruminal microbiota and fermentation of fattening lambs. Wen qin HUANG,Kai CUI,Yong HAN,Jian min CHAI,Shi qin WANG,Xiao kang LÜ,Qi yu DIAO,Nai feng ZHANG. 2022

[9]Altered milk yield and rumen microbial abundance in response to concentrate supplementation during the cold season in Tibetan sheep. Lin Sheng Gui,Sayed Haidar Abbas Raza,Fathi Allam Easa Ahmed Allam,Li Zhou,Shengzhen Hou,Imran Khan,Ihsan Ullah Kakar,Ayman Hassan Abd El-Aziz,Jianlei Jia,Yonggang Sun,Zhiyou Wang. 2021

[10]Effects of Dietary Supplementation with Glycerol Monolaurate (GML) or the Combination of GML and Tributyrin on Growth Performance and Rumen Microbiome of Weaned Lambs. Yi Li,Heze Wang,Yulei Zhang,Xilong Li,Xianren Jiang,Hongbiao Ding. 2022

[11]Effect of dietary biochanin A on lactation performance, antioxidant capacity, rumen fermentation and rumen microbiome of dairy goat. Qingbiao Xu,Yanjun Li,Wenjuan Du,Nan Zheng,Jiaqi Wang,Shengguo Zhao. 2023

[12]Editorial: Rumen microbiome: interacting with host genetics, dietary nutrients metabolism, animal production, and environment. Qingbiao Xu,Emilio M. Ungerfeld,Diego P. Morgavi,Sinead M. Waters,Jinxin Liu,Wenjuan Du,Shengguo Zhao. 2023

[13]Expression and characterization of a novel microbial GH9 glucanase, IDSGLUC9-4, isolated from sheep rumen. Yongzhen Zhu,Shuning Bai,Nuo Li,Jun Hong Wang,Jia Kun Wang,Qian Wang,Kaiying Wang,Tietao Zhang. 2024

[14]Effect of red clover isoflavones on ruminal microbial composition and fermentation in dairy cows. Bu, Ying,Zhang, Xiaoyin,Xiong, Zhanbo,Li, Kexin,Zhang, Shiqi,Lin, Miao,Zhao, Guoqi,Zheng, Nan,Wang, Jiaqi,Zhao, Shengguo. 2025

[15]The roles of phytogenic feed additives, trees, shrubs, and forages on mitigating ruminant methane emission. Ibrahim Bature,Wu Xiaohu,Xuezhi Ding. 2024

[16]Allicin enhances urea-N conversion to microbial-N by inhibiting urease activity and modulating the rumen microbiome in cattle. Shiqi Zhang,Nan Zheng,Shengguo Zhao,Jiaqi Wang. 2025

[17]Metagenomic Insights into the Rumen Microbiome in Solid and Liquid Fractions of Yaks and their Differences Compared to Other Ruminants. Yan, Xiaoting,Xie, Fei,Yang, Shuo,Sun, Yishan,Lei, Yu,Ren, Qingmiao,Si, Huazhe,Li, Zhipeng,Qiu, Qiang. 2025

[18]Editorial: Crosslinking of feed nutrients, microbiome and production in ruminants. Wenjuan Du,Wenjie Xu,Yin Hu,Shengguo Zhao,Fuyong Li,Deguang Song,Junshi Shen,Qingbiao Xu. 2025

[19]The role of the gut microbiome in the regulation of high-altitude adaptation. Zhang, Xinyu,Zhu, Senlin,Kreuzer, Michael,Ji, Shoukun,Wang, Wei,Bi, Yanliang,Li, Shengli. 2026

[20]Dietary energy levels modulate rumen metabolites and function in sheep by regulating the rumen microbiome. Yize Song,Senxuan Hou,Yuping Xiang,Dongbin Zou,Shiyu Gu,Xiufen Pu,Qing Liu,Mingxing Chu. 2025

作者其他论文 更多>>