数字农科院2.0

A getah virus-like-particle vaccine provides complete protection from viremia and arthritis in wild-type mice

文献类型: 外文期刊

作者: Miao, Qiuhong;Nguyen, Wilson;Zhu, Jie;Liu, Guangqing;van Oers, Monique M.;Tang, Bing;Yan, Kexin;Larcher, Thibaut;Suhrbier, Andreas;Pijlman, Gorben P.

作者机构:

关键词: Getah virus;Virus-like-particle;Vaccine;Baculovirus;Mouse model

期刊名称: VACCINE

ISSN: 0264-410X

年卷期: 2024 年 42 卷 25 期

页码:

收录情况: SCIE(2024版)

摘要: Getah virus (GETV) is an emerging mosquito-borne virus with economic impact on the livestock industry in East Asia. In this study, we successfully produced GETV virus-like particles (VLPs) in insect cells using the baculovirus expression vector system. We show that the GETV envelope glycoproteins were successfully expressed at the surface of the insect cell and were glycosylated. VLPs were isolated from the culture fluid as enveloped particles of 60-80 nm in diameter. Two 1 mu g vaccinations with this GETV VLP vaccine, without adjuvant, generated neutralizing antibody responses and protected wild-type C57/BL6 mice against GETV viremia and arthritic disease. The GETV VLP vaccine may find application as a horse and/or pig vaccine in the future.

分类号:

  • 相关文献

[1]The ecdysteroid UDP-glucosyltransferase gene promoter from Autographa californica multicapsid nucleopolyhedrovirus. Shen, XJ,Yi, YZ,Tang, SM,Zhang, ZF,Li, YR,He, JL.

[2]马流感灭活疫苗的研制. 郭巍,戚亭,相文华,王晓钧. 2015

[3]Cloning and Functional Analysis of the Full Length cDNA Sequence of Eukaryotic Translation Initiation Factor 5 in Schistosoma japonicum. Cheng Guofeng,Lin Jiaojiao,Sun Jun,Li Hao,Zhu Chuangang,Zhou Yuancong,Cai Youmin. 2005

[4]ProtectiveimmunityinducedbyaDNAvaccineexpressingeIF4AofToxoplasmagondiiagainstacutetoxoplasmosisinmice. 陈佳,SiyangHuang,ZhongyuanLi,ZiguoYuan,DonghuiZhou,EskildPetersen,NianzhangZhang,XingquanZhu. 2013

[5]传染性法氏囊病病毒反向遗传技术发展及其应用DevelopmentandApplicationoftheReverseGeneticTechnologiesforInfectiousBursalDiseaseVirus. 祁小乐1,王永强1,高立1,高宏雷1,高玉龙1,王笑梅1,2*QIXiaole1,WANGYongqiang1,GAOLi1,GAOHonglei1,GAOYulong1,WANGXiaomei1,2*. 2015

[6]运用反向遗传学培养产生高成长性的猪流感疫苗(英文). TaoYangMingLiuChunguoLiuYunZhangDafeiLiuHaoChenBiotechnologyAnimalInfluenzaLaboratoryoftheMinistryAgricultureandNationalKeyLaboratoryofVeterinary,HarbinVeterinaryResearchInstituteofCAAS,Harbin150001,China. 2007

[7]表达H3N8亚型马流感病毒重组禽痘病毒载体疫苗的研究. 戚亭,郭巍,王晓钧. 2015

[8]A coagulase-negative and non-haemolytic strain of Staphylococcus aureus for investigating the roles of SrtA in a murine model of bloodstream infection. Wang, Lin,Deng, Xuming,Bi, Chongwei,Wang, Tiedong,Hu, Jinping,Liu, Bingrun,Zhong, Xiaobo,Wang, Dacheng,Xiang, Hua,Cai, Hongjun,Chen, Fuguang.

[9]A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice. Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Sun, Weiyang,Zhang, Xinghai,Li, Yuanguo,Wang, Tiecheng,Wang, Hualei,Xin, Yue,Li, Xue,Zhang, Kun,Huang, Jing,Yang, Songtao,Gao, Yuwei,Xia, Xianzhu,Cheng, Kaihui,Zhang, Qianyi,Chen, Hualan,Wilker, Peter R.,Yue, Donghui,Gao, Yuwei,Xia, Xianzhu,Xia, Xianzhu.

[10]Characterization of a highly pathogenic H5N1 influenza virus derived from bar-headed geese in China. Zhou, JY,Shen, HG,Chen, HX,Tong, GZ,Liao, M,Yang, HC,Liu, JX.

[11]An adapted duck Tembusu virus induces systemic infection and mediates antibody-dependent disease severity in mice. Liu, Zongliang,Ji, Yanhong,Huang, Xiaohui,Fu, Yuguang,Cai, Xuepeng,Zhu, Qiyun,Wei, Jianzhong.

[12]Evaluation of the Immunogenicity of a Pool of Recombinant Lactococcus lactis Expressing Eight Antigens of African Swine Fever Virus in a Mouse Model. Jingshan Huang,Tianqi Gao,Zhanhao Lu,Dailang Zhong,Mingzhi Li,Hua Ji Qiu,Yongfeng Li,Hongxia Wu,Yuan Sun. 2025

[13]Detoxification of Insect-Derived Allergen PLA2 via Quercetin Modification: Molecular Simulation and Animal Validation. Fukai Li,Liming Wu,Min Wang,Enning Zhou,Fei Pan,Jian Zhou,Mengrui Yang,Tongtong Wang,Liang Li,Qiangqiang Li. 2025

[14]Structural Insights into Alphavirus Assembly Revealed by the Cryo-EM Structure of Getah Virus. Ming Wang,Zhenzhao Sun,Chenxi Cui,Shida Wang,Decheng Yang,Zhibin Shi,Xinyu Wei,Pengfei Wang,Weiyao Sun,Jing Zhu,Jiaqi Li,Bingchen Du,Zaisi Liu,Lili Wei,Chunguo Liu,Xijun He,Xiangxi Wang,Xinzheng Zhang,Jingfei Wang. 2022

[15]Rapid Differential Detection of Japanese Encephalitis Virus and Getah Virus in Pigs or Mosquitos by a Duplex TaqMan Real-Time RT-PCR Assay. Zhang Y.,Li Y.,Guan Z.,Yang Y.,Zhang J.,Sun Q.,Li B.,Qiu Y.,Liu K.,Shao D.,Ma Z.,Wei J.,Li P.. 2022

[16]Rapid Visual Detection Of Getah V.irus Using A Loop-Mediated I sothermal Amplification Method. Liu, H, Li, LX, Bu, YP, Liu, Y, Sun, XT, Shi, N, Deng, XY, Lu, RG, Hu, B, Jin, NY, Yan, XJ. 2019

[17]Seroprevalence of Getah virus in Pigs in Eastern China Determined with a Recombinant E2 Protein-Based Indirect ELISA. Sun Q.,Xie Y.,Guan Z.,Zhang Y.,Li Y.,Yang Y.,Zhang J.,Li Z.,Qiu Y.,Li B.,Liu K.,Shao D.,Wang J.,Ma Z.,Wei J.,Li P.. 2022

[18]The host transcriptome change involved in the inhibitory effect of exogenous interferon-γ on Getah virus replication. Jialei Li,Xintao Gao,Xingjian Liu,Tong Wu,Haozhi Song,Weisong Gao,Hong Jia,Yinü Li,Zhifang Zhang. 2023

[19]The Isolation and Characterization of a Novel Group III-Classified Getah Virus from a Commercial Modified Live Vaccine against PRRSV. Xintao Gao,Jialei Li,Tong Wu,Jinping Dou,Wenrong Zhang,Hong Jia,Zhifang Zhang,Xingjian Liu,Yinü Li. 2023

[20]Rapid Detection of Getah Virus Antibodies in Horses Using a Recombinant E2 Protein-Based Immunochromatographic Strip. Dengke Zhong,Jiayang Zheng,Zhiyong Ma,Yan Wang,Jianchao Wei. 2024

作者其他论文 更多>>