数字农科院2.0

Efficient Synthesis Of Isoquinolines In W.ater By A Pd-Catalyzed T andem Reaction Of Functionalized Alkylnitriles With Arylboronic Acids

文献类型： 外文期刊

作者： Hu, K; Qi, LJ; Yu, SL; Cheng, TX; Wang, XD; Li, ZJ; Xia, YZ; Chen, JX; Wu, HY

作者机构：

期刊名称： GREEN CHEMISTRY

ISSN： 1463-9262

年卷期： 2017 年 19 卷 7 期

页码：

收录情况： JCR（2021版） ; EI（2021版）

摘要： A palladium-catalyzed tandem reaction of 2-(cyanomethyl) benzonitriles or 2-(2-carbonylphenyl) acetonitriles with arylboronic acids in water has been developed for the first time. This reaction features good functional group tolerance and provides a new strategy for the synthesis of diverse isoquinolines under mild conditions. The use of water as the reaction medium makes the synthesis process environmentally benign. Preliminary mechanistic experiments indicate that the major reaction pathway involves carbopalladation of the C(sp(3))-cyano group and subsequent intramolecular cyclization findings that were further supported by density functional theory (DFT) calculations.

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