文献类型： 外文期刊
作者： Cheng, SH; Wu, PX; Han, J; Wang, YR; Cui, YT; Zhang, ZX; Yamagata, T; Li, XB
作者机构：
关键词： Neoglycosphingolipids; Stereoselective; One-step synthesis; MMP-9; Anti-tumor agent
期刊名称： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN： 0223-5234
年卷期： 2017 年 134 卷
页码：
收录情况： JCR（2021版）
摘要： Various neoglycosphingolipids were efficiently synthesized in a one-step reaction by the coupling of free sugars with an N-alkylaminooxy-functionalized ceramide analogue. The bioactivity studies demonstrated that most of these compounds could upregulate the expression of matrix metalloproteinase-9 (MMP-9, extracellular matrix proteins associated with tumor migration) in murine melanoma B16 cells in a similar manner to the natural ganglioside monosialodihexosylganglioside (GM3), which highlights the potential use of these neoglycosphingolipids as inhibitors of tumor migration. (C) 2017 Elsevier Masson SAS. All rights reserved.
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