Quercetin And Aconitine Synergistically Induces T.he Human Cervical Carcinoma H ela Cell Apoptosis Via Endoplasmic Reticulum (Er) Stress Pathway
文献类型： 外文期刊
作者： Li, XM; Liu, J; Pan, FF; Shi, DD; Wen, ZG; Yang, PL
作者机构：
期刊名称： PLOS ONE
ISSN： 1932-6203
年卷期： 2018 年 13 卷 1 期
页码：
收录情况： JCR（2021版）
摘要： Up till now, studies have not been conducted on how the combination of Quercetin (Q), Aconitine (A) and apoptosis induction affects human cervical carcinoma HeLa cells. The result of our findings shows that the combination of Q and A (QA) is capable of synergistically inhibiting the proliferation of HeLa cells in a number of concentrations. QA synergistically inhibits the proliferation of MDR1 gene in the HeLa cells. It is concluded based on our result that QA induces apoptosis and ER stress just as QA-induced ER stress pathway may mediate apoptosis by upregulating mRNA expression levels of eIF2 alpha, ATF4, IRE1, XBP1, ATF6, PERK and CHOP in the HeLa cells. The up-regulating of mRNA expression level of GRP78 and activation of UPR are a molecular basis of QA-induced ER stress.
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