数字农科院2.0

Antioxidant And Hemolysis Protective Effects O.f Polyphenol-Rich Extract From M ulberry Fruits

文献类型： 外文期刊

作者： Gui, Zhong-Zheng;Wang, Chu-Yan;Jia, Jun-Qiang;Sivakumar, Thasma Raman;Li, Shao-Hui;Yin, Juan;Gui, Zhong-Zheng;Jia, Jun-Qiang;Jin, Chao;Krishna, Palanigounder Ganeshan Ajay;Weng, Yu-Jie

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关键词： Antioxidant activity; hemolysis protective; mulberry fruit; polyphenols; purification

期刊名称： PHARMACOGNOSY MAGAZINE

ISSN： 0973-1296

年卷期： 2018 年 14 卷 53 期

页码：

摘要： Background: Mulberry fruits are a superior source of polyphenol, especially anthocyanins that contribute potentially to the beneficial effects which include reducing the risk of cardiovascular diseases and cancers with antioxidant, anti-inflammatory, and chemoprotective properties. Objectives: In this study, purification of the polyphenol-rich extract from mulberry fruit (MPE) was purified and assessed the activities of antioxidant and hemolysis protective in vivo and in vitro. Materials and Methods: Antioxidant activities in vitro was measured by quantifying its 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, reducing power and Fe2+-chelating ability. MPE was purified by high-pressure liquid chromatography (HPLC) and analyzed individual polyphenols using liquid chromatography-mass spectrometry (LC-MS)/MS. Results: The total polyphenol content was 147.69 +/- 0.02 mg gallic acid equivalents (GAE)/g dried weight (DW) in the extract and 403.55 +/- 0.02 mg GAE/g DW in the purified extract. Further identification by HPLC-ultraviolet-visible and LC-MS/MS analysis indicated in MPE, an anthocyanin compound, cyanidin-3-O-glucoside. With regard to in vitro assays, MPE possessed antioxidant effect, especially in Fe2+ chelating ability with an IC50 value of 1.016 mg/mL. The protective effects on mouse red blood cell hemolysis and lipid peroxidation ex vivo were dose and time dependent. Conclusion: It indicates that MPE could be a good candidate for future biomedical applications to promote human health with limited side effects.

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