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Bmnpv-Mir-415 Up-Regulates The Expression Of T.or2 Via Bmo-Mir-5738

文献类型： 外文期刊

作者： Guo, Xijie;Cao, Xueliang;Zhao, Qiaoling;Qiu, Zhiyong;Huang, Yong;Huang, Yong;Qiu, Zhiyong;Xia, Dingguo;Shen, Xingjia;Xia, Dingguo;Shen, Xingjia;Guo, Xijie;Cao, Xueliang;Zhao, Qiaoling

作者机构：

关键词： 3 ' UTR; MicroRNAs; Bombyx mori; BmNPV; TOR2

期刊名称： SAUDI JOURNAL OF BIOLOGICAL SCIENCES

ISSN： 1319-562X

年卷期： 2017 年 24 卷 7 期

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摘要： MicroRNAs (miRNAs) have emerged as key players in host-pathogen interaction and many virus-encoded miRNAs have been identified (computationally and/or experimentally) in a variety of organisms. A novel Bombyx mori nucleopolyhedrosis virus (BmNPV)-encoded miRNA miR-415 was previously identified through high-throughput sequencing. In this study, a BmNPV-miR-415 expression vector was constructed and transfected into BmN cells. The differentially expressed protein target of rapamycin isoform 2 (TOR2) was observed through two-dimensional gel electrophoresis and mass spectrometry. Results showed that TOR2 is not directly a target gene of BmNPV-miR-415, but its expression is up-regulated by BmNPV-miR-415 via Bmo-miR-5738, which could be induced by BmNPV. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

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