数字农科院2.0

Changes Of Host Dna Methylation I.n Domestic Chickens Infected W ith Salmonella Enterica

文献类型: 外文期刊

作者: Wang, F; Li, JC; Li, QH; Liu, RR; Zheng, MQ; Wang, Q; Wen, J; Zhao, GP

作者机构:

关键词: Salmonella enterica infection; chicken; DNA methylation

期刊名称: JOURNAL OF GENETICS

ISSN: 0022-1333

年卷期: 2017 年 96 卷 4 期

页码:

收录情况: JCR(2021版)

摘要: Cytosine methylation is an effective way to modulate gene transcription. However, very little is known about the epigenetic changes in the host that is infected with Salmonella enterica. In this study, we used methylated DNA immunoprecipitation sequencing to analyse the genomewide DNA methylation changes in domestic chickens after infected with Salmonella. The level of DNA methylation was slightly higher in the genomic regions around the transcription start termination sites in a Salmonella-infected group compared to the controls. Overall, 879 peaks were differentially methylated between Salmonella-infected and control groups, among which 135 were located in the gene promoter regions. Genes including MHC class IV antigen, GABARAPL1, MR1 and KDM1B were shown to be methylated more heavily after infected with Salmonella, whereas DYNLRB2, SEC14L3 and ANKIB1 tended to have fewer methylated cytosine residues in the promoter regions. Gene interaction network analysis of differentially methylated genes in the promoter regions revealed extensive connections with immune-related genes, indicating the possible impact of infection with Salmonella on the epigenetic status of the host.

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