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Aspirin Eugenol Ester Regulates Cecal C.ontents Metabolomic Profile And M icrobiota In An Animal Model Of Hyperlipidemia

文献类型： 外文期刊

作者： Ma, Ning;Jiao, Zeng-Hua;Li, Jian-Yong;Li, Shi-Hong;Liu, Xi-Wang;Ma, Ning;Qin, Zhe;Yang, Ya-Jun;Kong, Xiao-Jun

作者机构：

关键词： Aspirin eugenol ester; Gut microbiota; Metabonomics; Cecal contents; Hyperlipidemia; UPLC-Q-TOF; MS; High fat diet

期刊名称： BMC VETERINARY RESEARCH

ISSN： 1746-6148

年卷期： 2018 年 14 卷

页码：

摘要： BackgroundHyperlipidemia, with an increasing of prevalence, has become one of the common metabolic diseases in companion animal clinic. Aspirin eugenol ester (AEE) is a novel compound that exhibits efficacious anti-hyperlipidemia activities. However, its mechanisms are still not completely known. The objective of present study was to investigate the intervention effects of AEE on cecal contents metabonomics profile and microbiota in hyperlipidemia rats.ResultsThree groups of rats were fed with a control diet, or high fat diet (HFD) containing or not AEE. The results showed the beneficial effects of AEE in HFD-fed rats such as the reducing of aspartate aminotransferase (AST) and total cholesterol (TCH). Distinct changes in metabonomics profile of cecal contents were observed among control, model and AEE groups. HFD-induced alterations of eight metabolites in cecal contents mainly related with purine metabolism, linoleic acid metabolism, glycerophospholipid metabolism, sphingolipid metabolism and pyrimidine metabolism were reversed by AEE treatment. Principal coordinate analysis (PCoA) and cluster analysis of microbiota showed altered patterns with distinct differences in AEE group versus model group, indicating that AEE treatment improved the negative effects caused by HFD on cecal microbiota. In addition, the correction analysis revealed the possible link between the identified metabolites and cecal microbiota.ConclusionsThis study showed regulation effects of AEE on cecal contents metabonomics profile and microbiota, which could provide information to reveal the possible underlying mechanism of AEE on hyperlipidemia treatment.

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