数字农科院2.0

Ovotransferrin Ameliorates The Dysbiosis Of I.mmunomodulatory Function And Intestinal M icrobiota Induced By Cyclophosphamide

文献类型： 外文期刊

作者： Xu, Mingsheng;Xu, Mingsheng;Yao, Yao;Wu, Na;Yao, Yao;Zhu, Gaoxiang;Wu, Na;Tu, Yonggang;Hu, Mingwen;Jiang, Yan;Zhu, Gaoxiang;Hu, Mingwen;Tu, Yonggang;Luo, Jing;Jiang, Yan

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期刊名称： FOOD & FUNCTION

ISSN： 2042-6496

年卷期： 2019 年 10 卷 2 期

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摘要： In this study, the regulative effects of ovotransferrin (OVT) on immunomodulatory function and intestinal microbial dysbiosis in a mouse model injected with cyclophosphamide (CP) were investigated. The immunomodulatory effect of OVT was determined by enzyme-linked immune sorbent assay (ELISA). Gut microbial composition was determined by high-throughput sequencing of the V3-V4 region of the 16S rDNA gene. The changes in the relative abundance of the dominant microbiota were analyzed at different taxonomic levels. The results showed that OVT alleviated the immune dysfunction caused by CP. OVT improved the spleen and thymus indices and enhanced the secretion of tumor necrosis factor alpha (TNF-), interleukin-10 (IL-10), and immunoglobulin A (IgA). In addition, OVT increased the indexes of Shannon and Simpson, suggesting the enhancement of the diversity and richness of intestinal microflora. The relative abundance of Lachnospiraceae_NK4A136_group was also increased. However, the relative abundance of Helicobacter and Desulfovibrio was significantly decreased. These results indicated that OVT, a food-derived functional component, has effects on immune regulation in the organism and ameliorates the gut microbiota disorders induced by CP, which provides a potential therapeutic utilization of avian eggs by targeting the gut microbiome.

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