数字农科院2.0

Rational Design Of A Lysosomal-Targeted Ratiometric Two-Photon Fluorescent Probe For Imaging Hydrogen Polysulfides In Live Cells

文献类型： 外文期刊

作者： Han, QX; Liu, X; Wang, XC; Yin, RJ; Jiang, HE; Ru, JX; Liu, WS

作者机构：

关键词： Lysosome-Targeting; Ratiometric; Two-Photon; Fluorescent Probe; Hydrogen Polysulfide

期刊名称： DYES AND PIGMENTS

ISSN： 0143-7208

年卷期： 2020 年 173 卷

页码：

收录情况： JCR（2021版） ; EI（2021版）

摘要： Hydrogen polysulfides (H2Sn, n > 1) play important roles in H2S associated physiological functions and pathological processes and H2S2 is regarded to be a newfound potent signal transducer. But fluorescent probes for rapid, sensitive, and selective detecting of H2Sn are still lacking, above all the lysosomal-targeted ones. In this work, by integrating the alkylmorpholine group and 2-fluoro-5-nitrobenzoyl- group into the molecular structure of 1,8-naphthalimide based fluorophore, a new lysosome-targetable ratiometric two-photon fluorescent probe for H2Sn has been designed and synthesized. The probe showed good stability, short response time (5 min), high selectivity and sensitivity (LOD = 10 nM), broad linear range (0-25 mu M), admirable two-photon absorption cross sections (Phi(max) = 324 GM), fine membrane permeability and biocompatibility, and as well as the lysosome targeting ability. Moreover, this work affords a promising approach for detecting and imaging of lysosomal H2Sn, and therefore potentially applied in the study of H2Sn-related biology and pathology.

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